Rapid and sensitive gas chromatographic method for detection of barbital and pentobarbital in blood using flash-heater methylation and nitrogen-specific detection

Kim, C.; Berg, R. J. Van Den; Khanna, J. M.

doi:10.1007/bf02311778

Cited by 3 publications

(1 citation statement)

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“…For pentobarbital analysis, 100 gl blood samples were obtained in the same manner, and were acidified, extracted and analyzed by gas-liquid chromatography by an on-column methylation procedure (Kim et al 1987).…”

Section: Drug Analysismentioning

confidence: 99%

The contribution of environmental cues to cross-tolerance between ethanol and pentobarbital

El-Ghundi

Kalant

Lê³

et al. 1989

Psychopharmacology

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The contribution of Pavlovian conditioning of environmental cues has been studied in relation to tolerance to ethanol-induced hypothermia and cross-tolerance to pentobarbital. Two groups of 12 male Sprague-Dawley rats were exposed every other day to a distinctive set of environmental cues paired with an IP injection of either ethanol 2.5 g/kg or an equivalent volume of isotonic saline. On alternating non-drug days, both groups received saline in the animal room. When they were tested for tolerance to the hypothermic effect of ethanol 2.5 g/kg and cross-tolerance to pentobarbital 25 mg/kg in each environment, tolerance and cross-tolerance in the ethanol-treated group were significantly more pronounced in the ethanol-paired environment than in the saline-paired environment. This indicates the importance of a conditional factor in tolerance and cross-tolerance in this paradigm. Determination of blood levels of ethanol and pentobarbital at various times after injection indicated that conditioned tolerance and cross-tolerance can be explained in part by dispositional factors.

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Section: Drug Analysismentioning

confidence: 99%