2019
DOI: 10.1007/s11419-019-00479-w
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Rapid and robust speciation/quantitative analysis of arsenous acid and related metabolites in serum by liquid chromatography–inductively coupled plasma-tandem mass spectrometry

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Cited by 3 publications
(2 citation statements)
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“… 36 , 138 , 139 , 141 For example, proteins that contain covalently bound metals ( e.g. , Se 142 and As 143 ) are amenable to conventional strategies, including multidimensional methods involving reverse-phase, hydrophilic liquid chromatography (HILIC), and size exclusion chromatography (SEC) and ion exchange. In general, the principle of the LC-ICP-MS technique combines the potential for high-resolution separation of metallobiomolecules by LC with the elemental detection sensitivity of ICP-MS. 36 , 139 Although LC-ICP-MS presents diverse applications in metallomics, especially those associated to metalloproteins, the instability of the analyte signal caused by a low flow LC system, as well as the use of a mobile phase with high concentration of salt or with high composition of organic solvent, can negatively affect its stability and reduce the sensitivity of the technique, causing misunderstandings in quantification studies.…”
Section: State Of the Art In Metallomics: From Sampling To Quantificamentioning
confidence: 99%
“… 36 , 138 , 139 , 141 For example, proteins that contain covalently bound metals ( e.g. , Se 142 and As 143 ) are amenable to conventional strategies, including multidimensional methods involving reverse-phase, hydrophilic liquid chromatography (HILIC), and size exclusion chromatography (SEC) and ion exchange. In general, the principle of the LC-ICP-MS technique combines the potential for high-resolution separation of metallobiomolecules by LC with the elemental detection sensitivity of ICP-MS. 36 , 139 Although LC-ICP-MS presents diverse applications in metallomics, especially those associated to metalloproteins, the instability of the analyte signal caused by a low flow LC system, as well as the use of a mobile phase with high concentration of salt or with high composition of organic solvent, can negatively affect its stability and reduce the sensitivity of the technique, causing misunderstandings in quantification studies.…”
Section: State Of the Art In Metallomics: From Sampling To Quantificamentioning
confidence: 99%
“…Different kinds of techniques have been employed for the detection of toxic metal ions. Until now, well-known methods for the identification of toxic metal ions have been based primarily on instrumental methods, including atomic absorption spectroscopy, ICP-MS, and electrochemical analysis. However, these approaches suffer from some problems such as being time-consuming, having a high cost, and are difficult to transfer. So, it is necessary to develop a novel and effective method for detecting Cr­(VI) and Mn­(VII) contaminants.…”
Section: Introductionmentioning
confidence: 99%