Rapid and label-free Raman detection of azodicarbonamide with asthma risk

Li, Menghua; Guo, Xiaoyu; Wang, Hui; Wen, Ying; Yang, Haifeng

doi:10.1016/j.snb.2015.04.103

Cited by 18 publications

(13 citation statements)

References 45 publications

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“…50 nm were synthesized by the addition of 1 mL of 1wt.% HAuCl 4 to 47 mL of water, and the mixture was heated to 100 °C when 1.5 mL of Na 3 C 6 H 5 O 7 were injected [ 18 , 19 ]. The reaction mixture was preserved at 100 °C for 45 min, until its color became red, and was then cooled at 25 °C [ 18 , 19 ]. The colloidal solution of Au, with a particle size of 50 nm, had a particle concentration equal to 1.05 × 10 11 particles/mL [ 19 ].…”

Section: Methodsmentioning

confidence: 99%

“…The Au nanoparticles with a size of cca. 50 nm were synthesized by the addition of 1 mL of 1wt.% HAuCl 4 to 47 mL of water, and the mixture was heated to 100 • C when 1.5 mL of Na 3 C 6 H 5 O 7 were injected [18,19]. The reaction mixture was preserved at 100 • C for 45 min, until its color became red, and was then cooled at 25 • C [18,19].…”

Section: Methodsmentioning

confidence: 99%

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Reduced Graphene Oxide Sheets as Inhibitors of the Photochemical Reactions of α-Lipoic Acid in the Presence of Ag and Au Nanoparticles

et al. 2020

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The influence of Ag and Au nanoparticles and reduced graphene oxide (RGO) sheets on the photodegradation of α-lipoic acid (ALA) was determined by UV-VIS spectroscopy. The ALA photodegradation was explained by considering the affinity of thiol groups for the metallic nanoparticles synthesized in the presence of trisodium citrate. The presence of excipients did not induce further changes when ALA interacts with Ag and Au nanoparticles with sizes of 5 and 10 nm by exposure to UV light. Compared to the Raman spectrum of ALA powder, changes in Raman lines’ position and relative intensities when ALA has interacted with films obtained from Au nanoparticles with sizes between 5 and 50 nm were significant. These changes were explained by considering the chemical mechanism of surface-enhanced Raman scattering (SERS) spectroscopy. The photodegradation of ALA that had interacted with metallic nanoparticles was inhibited in the presence of RGO sheets.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Reduced Graphene Oxide Sheets as Inhibitors of the Photochemical Reactions of α-Lipoic Acid in the Presence of Ag and Au Nanoparticles

et al. 2020

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“…The use of ADC as a food additive continues to be controversial. In 1999, the World Health Organization (WHO) concluded that exposure to ADC caused respiratory problems, allergies, and asthma, 6,10 and that the level of risk associated with these exposures to the general public was uncertain, therefore the level of exposure should be reduced as much as possible 6 . The UK Health and Safety Agency has identified ADC as a respiratory sensitizer in the workplace environment, which has resulted in its inclusion in the 2012 REACH regulation of very concerning substances 11 .…”

Section: Introductionmentioning

confidence: 99%

Development of a simultaneous analysis method of azodicarbonamide, semicarbazide, and hydrazine in flour products using HPLC

Choi

Lim

Shin

2022

Bulletin Korean Chem Soc

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Azodicarbonamide (ADC) has been used as a flour bleaching agent or dough conditioner. A high‐performance liquid chromatography method was developed for simple and simultaneous analysis of ADC, semicarbazide (SEM), and hydrazine (HZ) using 4‐ethylbenzaldehyde (4‐EBA). Samples were extracted with methanol at neutral pH, and the extracts were concentrated at pH 1.0 and derivatized with 4‐EBA at pH 3. It was identified that ADC was decomposed to SEM, which was continually decomposed to HZ in an aqueous solution. This method was applied to the analysis of wheat flour products, and the results showed that SEM was detected up to a concentration of 0.42 mg/kg, but HZ was not detected in wheat flour products. The developed method enabled simple, less time‐consuming, and simultaneous analysis, and can be utilized to effectively evaluate ADC, SEM, and HZ concentrations in wheat flour products.

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“…Surface‐enhanced Raman spectroscopy technique has also been employed for rapid and on‐site determination of SEM in flour samples. However, the sensitivity, selectivity, and enhanced reproducibility of surface‐enhanced Raman spectroscopy method is low, needing further improvement . ELISA is a sensitive method for the analysis of SEM and has been introduced for determination of trace SEM in meat samples .…”

Section: Introductionmentioning

confidence: 99%

Rapid determination of trace semicarbazide in flour products by high‐performance liquid chromatography based on a nucleophilic substitution reaction

Wei

Zhang

2017

J of Separation Science

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Semicarbazide, a toxic food contaminant, widely exists in food products and it originates from the thermal degradation of a food additive of azodicarbonamide or a metabolite of nitrofurazone abused in meat specimens. Many previous methods for semicarbazide determination usually required expensive instruments, difficult-to-prepare monoclonal antibodies, and a long operation time. In this study, a high-performance liquid chromatography method was developed for the rapid determination of trace semicarbazide coupling with a nucleophilic substitution reaction firstly using 4-nitrobenzoyl chloride as derivatization reagent. The derivatization reaction was mild at room temperature for 1 min in neutral solution. Then, semicarbazide derivative was separated and quantified by high-performance liquid chromatography with ultraviolet detection under optimal separation conditions at λ = 261 nm. The proposed method offered the detection limit of 1.8 μg/L and was successfully applied for the rapid determination of trace semicarbazide in flour products. Semicarbazide in positive real samples could be actually found and quantified in the range of 0.47-7.53 mg/kg. The recoveries were 76.6-119% with relative standard deviations of 0.5-9.1% (n = 3). This developed method was rapid, reliable, and convenient for the determination of trace semicarbazide in food.

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Rapid and label-free Raman detection of azodicarbonamide with asthma risk

Cited by 18 publications

References 45 publications

Reduced Graphene Oxide Sheets as Inhibitors of the Photochemical Reactions of α-Lipoic Acid in the Presence of Ag and Au Nanoparticles

Reduced Graphene Oxide Sheets as Inhibitors of the Photochemical Reactions of α-Lipoic Acid in the Presence of Ag and Au Nanoparticles

Development of a simultaneous analysis method of azodicarbonamide, semicarbazide, and hydrazine in flour products using HPLC

Rapid determination of trace semicarbazide in flour products by high‐performance liquid chromatography based on a nucleophilic substitution reaction

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