Rapid and high yield isolation of extracellular vesicles with purity by application of size exclusion fast performance liquid chromatography
Kshipra S. Kapoor,
Kristen Harris,
Kent Arian
et al.
Abstract:Extracellular Vesicles (EVs) have emerged as potential biomarkers for diagnosing a range of diseases without invasive procedures. Extracellular vesicles also offer an advantage compared to synthetic vesicles, for delivery of various drugs. However, limitations in segregating EVs from soluble proteins have led to inconsistent EV retrieval rates with low levels of purity. Here, we report a new high-yield (>95%) and rapid (<20 min) EV isolation method called Size Exclusion Fast Performance Liquid Chromatogr… Show more
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