Rapid and Direct Spectrofluorometric and Chemometrics Methods for the Simultaneous Determination of Two Dansyl Derivatives

Riahi, Siavash; Hariri, Maryam; Norouzi, Parviz

doi:10.1080/00387010903321737

Cited by 2 publications

(1 citation statement)

References 43 publications

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“…So, several different approach were developed to solve this problem like simultaneous equation (Pandey et al 2014;Tiwari and Pillai 2011), Q-absorbance ratio (Pandey et al 2014;Thankappan et al 2012), and absorbance ratio (Tiwari and Pillai 2011) method which were used to resolve the overlapping spectrum of conventional spectrophotometry for the simultaneous determination of ET and TC. Recently, chemometrics techniques containing several multivariate calibration calculations (Riahi et al 2010;Sankar et al 2011) in combination with spectrophotometry have been applied to resolve the overlapping spectra of mixtures of drugs in pharmaceuticals because multivariate methods allow to filter interferences of analyzed substance and have several advantages such as lower usage of chemicals, manpower, less time consumed, reasonable accuracy, and precision without chromatographic separation procedures. To the best of our knowledge, there are no publications for the simultaneous determination of ET and TC based on the coupling of UV-Vis spectroscopy and multivariate calibration methods.…”

Section: Introductionmentioning

confidence: 99%

Design, optimization, and validation of chemometrics-assisted spectrophotometric methods for simultaneous determination of etodolac and thiocolchicoside in pharmaceuticals

et al. 2019

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Etodolac (ET) is a nonsteroidal anti-inflammatory drug (NSAID) that shows anti-inflammatory, analgesic, and antipyretic activities. Various NSAIDs have been demonstrated to enhance analgesia such as thiocolchicoside (TC) which is also an anti-inflammatory analgesic with muscle relaxant properties. A new quantitative method by using the data obtained from chemometrics calibration partial least squares (PLS), principal component regression (PCR), and inverse least squares (ILS) was developed for the simultaneous analysis of ET and TC without any separation process in combined pharmaceutical products. The calibration (25 samples) and validation (8 samples) concentration data matrices were prepared by using the mixtures containing ET (15-75 μg/mL) and TC (1-10 μg/mL) via factorial design method. The absorbance values were measured in the 240-440 nm. The recovery % of PLS, PCR, and CLS methods were found as ≤ 98.26%, 98.16%, and 98.17% for ET and 99.14%, 98.26%, and 98.15% for TC, respectively. These three chemometric techniques, which do not require neither separation nor derivatization steps, were confidentially applied for the determination of ET and TC in combined formulations. In conclusion, it is claimed that these new chemometrics-assisted spectrophotometric methods are inexpensive, rapid, and simple and can be trustfully carried out in quality control laboratories as an alternative to existing methods.

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Section: Introductionmentioning

confidence: 99%

Design, optimization, and validation of chemometrics-assisted spectrophotometric methods for simultaneous determination of etodolac and thiocolchicoside in pharmaceuticals

et al. 2019

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A new technique for spectrophotometric determination of Pseudoephedrine and Guaifenesin in syrup and synthetic mixture

Riahi

Hadiloo

Milani

et al. 2011

Drug Testing and Analysis

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The accuracy in predicting different chemometric methods was compared when applied on ordinary UV spectra and first order derivative spectra. Principal component regression (PCR) and partial least squares with one dependent variable (PLS1) and two dependent variables (PLS2) were applied on spectral data of pharmaceutical formula containing pseudoephedrine (PDP) and guaifenesin (GFN). The ability to derivative in resolved overlapping spectra chloropheniramine maleate was evaluated when multivariate methods are adopted for analysis of two component mixtures without using any chemical pretreatment. The chemometrics models were tested on an external validation dataset and finally applied to the analysis of pharmaceuticals. Significant advantages were found in analysis of the real samples when the calibration models from derivative spectra were used. It should also be mentioned that the proposed method is a simple and rapid way requiring no preliminary separation steps and can be used easily for the analysis of these compounds, especially in quality control laboratories.

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Rapid and Direct Spectrofluorometric and Chemometrics Methods for the Simultaneous Determination of Two Dansyl Derivatives

Cited by 2 publications

References 43 publications

Design, optimization, and validation of chemometrics-assisted spectrophotometric methods for simultaneous determination of etodolac and thiocolchicoside in pharmaceuticals

Design, optimization, and validation of chemometrics-assisted spectrophotometric methods for simultaneous determination of etodolac and thiocolchicoside in pharmaceuticals

A new technique for spectrophotometric determination of Pseudoephedrine and Guaifenesin in syrup and synthetic mixture

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