Rapid analysis of nine lignans in Schisandra chinensis by supercritical fluid chromatography using diode array and mass spectrometric detection

Onay, Sevil; Hofer, Stefanie; Ganzera, Markus

doi:10.1016/j.jpba.2020.113254

Cited by 21 publications

(5 citation statements)

References 28 publications

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“…A study conducted using supercritical fluid chromatography and DAD detected the presence of 9 lignans in S. chinensis, and the results indicated that schisandrol A was the most abundant lignan, followed by schisandrin B (syn. Gomisin N) or schisandrol B ( 47 ). Therefore, Schisandrol A is the predominant component of lignans in S. chinensis .…”

Section: Nutritional and Active Components Of Schisandra Ch...mentioning

confidence: 99%

An analysis of the nutritional effects of Schisandra chinensis components based on mass spectrometry technology

Jia¹,

Li²,

Lou³

et al. 2023

Front. Nutr.

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ObjectiveSchisandra chinensis (Turcz.) Baill. (S. chinensis) is a Traditional Chinese medicinal herb that can be used both for medicinal purposes and as a food ingredient due to its beneficial properties, and it is enriched with a wide of natural plant nutrients, including flavonoids, phenolic acids, anthocyanins, lignans, triterpenes, organic acids, and sugars. At present, there is lack of comprehensive study or systemic characterization of nutritional and active ingredients of S. chinensis using innovative mass spectrometry techniques.MethodsThe comprehensive review was conducted by searching the PubMed databases for relevant literature of various mass spectrometry techniques employed in the analysis of nutritional components in S. chinensis, as well as their main nutritional effects. The literature search covered the past 5 years until March 15, 2023.ResultsThe potential nutritional effects of S. chinensis are discussed, including its ability to enhance immunity, function as an antioxidant, anti-allergen, antidepressant, and anti-anxiety agent, as well as its ability to act as a sedative-hypnotic and improve memory, cognitive function, and metabolic imbalances. Meanwhile, the use of advanced mass spectrometry detection technologies have the potential to enable the discovery of new nutritional components of S. chinensis, and to verify the effects of different extraction methods on these components. The contents of anthocyanins, lignans, organic acids, and polysaccharides, the main nutritional components in S. chinensis, are also closely associated to its quality.ConclusionThis review will provide guidelines for an in-depth study on the nutritional value of S. chinensis and for the development of healthy food products with effective components.

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Section: Nutritional and Active Components Of Schisandra Ch...mentioning

confidence: 99%

An analysis of the nutritional effects of Schisandra chinensis components based on mass spectrometry technology

Jia¹,

Li²,

Lou³

et al. 2023

Front. Nutr.

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“…The Base Peak Chromatogram (BPC) was observed in Figure 1 by using the UPLC-QTOF-MS condition described above. In positive-ion mode, 26 monomer compounds were identified (Gao et al, 2019;Guo et al, 2021;He et al, 2013;Huang et al, 2008;Lee et al, 2013;Lei et al, 2020;Li et al, 2016Li et al, , 2018Liu et al, 2013Liu et al, , 2017Onay et al, 2020;Shi et al, 2009;Sun et al, 2019;Yang et al, 2017;Zhang et al, 2017;Zhou et al, 2011), all of which were lignans in Table 1. The specific secondary cracking process of the representative compound is shown in Figure 2.…”

Section: The Chemical Constituents Of Scmentioning

confidence: 99%

Mechanism of Schisandra chinensis in Treatment of Insomnia by Sleep–Wake Cycle Based on Network Pharmacology

Liang,

Qiao,

Sun

et al. 2023

Pharmacognosy Magazine

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Background Schisandra chinensis (SC) is the dried fruit of SC of Magnoliaceae, which has been used to treat many diseases, such as asthma, cough, insomnia, spontaneous sweating, and so on, for more than 2000 years. Lignans are important active ingredients of SC for improving insomnia, but it is not clear the exact material basis and mechanism of action. Objectives This study aimed to discover the mechanism by which SC treats insomnia through network pharmacology. Materials and Methods It was used to study the chemical constituents of SC by ultra-high-performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC-QTOF-MS). The SC–Insomnia network and the protein–protein interaction (PPI) network were set up using network pharmacology to research the mechanisms by which SC treats insomnia. The targets found in network pharmacology were proven by enzyme-linked immunosorbent assays (ELISA) and real-time polymerase chain reactions (RT-PCR). Results It identified 26 monomer compounds, all of which were lignans. From the SC–Insomnia and PPI networks, seven main active lignans were discovered, which could play an important part in treating insomnia, along with 11 targets that play an important part in the sleep−wake cycle. It was verified by the expression of GABA with ELISA and GABRA1 with RT-PCR. Conclusion Based on network pharmacology, the mechanism by which SC treats insomnia is through the sleep–wake cycle. It was a foundation to rationally apply SC for treating insomnia in the clinic.

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“…To date, a variety of analytical methods have been developed for determining the components of S. chinensis, including high-performance liquid chromatography (HPLC), ultra-highperformance liquid chromatography-mass spectrometry (UPLC-MS), gas chromatographymass spectrometry, and supercritical fluid chromatography [13,[15][16][17]. However, conventional analytical strategies merely provide information on components and fail to objectively express the correlation between efficacy and quality [4,18].…”

Section: Introductionmentioning

confidence: 99%

Identification of Quality Markers in Schisandra chinensis (Turcz.) Baill. Using UPLC-Q-Extractive Orbitrap/MS, Chemometric Analysis, and Network Pharmacology

Wang,

Li,

Ding

et al. 2024

Separations

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Chemical composition is a critical factor for determining the efficacy of any traditional Chinese medicine (TCM) and can be used as an indicator of commercial quality. To develop a new strategy for discovering potential quality markers (Q-markers) of TCM by integrating ultra-performance liquid chromatography-Q-extractive orbitrap/mass spectrometry (UPLC-Q-Extractive Orbitrap/MS), chemometric analysis, and network pharmacology, using Schisandra chinensis (Turcz.) Baill. (S. chinensis) as an example. The chemical profiling of S. chinensis was performed using UPLC-Q-Extractive Orbitrap/MS, followed by identification of hepatoprotective Q-markers through a comprehensive understanding of chemometric analysis and virtual target prediction of network pharmacology. Six compounds were considered potent candidates for Q-markers, which were identified as schisandrol A (6), angeloylgomisin H (10), schisantherin A (17), schisantherin B (18), schisandrin A (23), and schisandrin C (26). All Q-markers exhibited significant hepatoprotective activity, as evidenced by in vitro experiments. Subsequently, a method for simultaneous quantification was established and employed to analyse seven batches of S. chinensis. Therefore, the integrated approach of UPLC-Q-Extractive Orbitrap/MS, chemometrics, and network pharmacology proved to be an effective strategy for the discovery of Q-markers that can assist in assessing the overall chemical consistency of samples and provide a basis for quality evaluation of the material basis of S. chinensis.

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Rapid analysis of nine lignans in Schisandra chinensis by supercritical fluid chromatography using diode array and mass spectrometric detection

Cited by 21 publications

References 28 publications

An analysis of the nutritional effects of Schisandra chinensis components based on mass spectrometry technology

An analysis of the nutritional effects of Schisandra chinensis components based on mass spectrometry technology

Mechanism of Schisandra chinensis in Treatment of Insomnia by Sleep–Wake Cycle Based on Network Pharmacology

Identification of Quality Markers in Schisandra chinensis (Turcz.) Baill. Using UPLC-Q-Extractive Orbitrap/MS, Chemometric Analysis, and Network Pharmacology

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