Rapid analysis of lithium in serum samples by thermal ionization ion mobility spectrometry

Parchami, Razieh; Tabrizchi, Mahmoud; Shahraki, Hassan; Moaddeli, Ali

doi:10.1007/s12127-020-00264-1

Cited by 6 publications

(7 citation statements)

References 38 publications

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“…Of these, 50% (n = 7) had good precision (RSD < 3%), 17,19,21,25,28,29,31 14% (n = 2) an acceptable precision (RSD between 3% and 5%), 17,28 and 36% (n = 5) had low precision with an RSD >5% 19,20,23,27,32 . The accuracy of 5 studies (36%) was good, 16–18,21,22 another 4 (29%) had low accuracy, 20,22,26,27 and 5 other studies did not report accuracy 16,19,24,25,28 …”

Section: Resultsmentioning

confidence: 98%

Existing and Emerging Technologies for Therapeutic Monitoring of Lithium

Pedraza-Sanabria,

Dodd,

Giraldo-Cadavid

et al. 2024

J Clin Psychopharmacol

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Background/Purpose Lithium is an effective psychoactive drug. It has a narrow therapeutic margin, with subtherapeutic levels or intoxication commonly occurring. Therapeutic drug monitoring (TDM) of lithium has several barriers. This scoping review aims to describe and analyze existing and emerging technologies for lithium TDM and to describe the lithium quantification parameters (precision, accuracy, detection limit) attributed to each technology. Method PubMed, Scopus, Web of Science, and Google Scholar were searched. Studies that described lithium quantification and complied with PRISMA-ScR guidelines were included. Articles selection was conducted by 2 researchers. Good precision was defined if its relative standard deviation <3%; acceptable, from 3% to 5%; and low, >5%. Accuracy was considered good if the error <5%; acceptable, 5%1 to 0%; and low if it was >10%. Results Of the 2008 articles found, 22 met the inclusion criteria. Of these, 14 studies concerned laboratory devices, in which precision was found to be low in one third of cases, and half had good precision. Accuracy of one third was good, another third was low, and the remaining third did not report accuracy. The other 8 studies concerned portable devices, in which precision was low in more than 60% of the cases and good in 25% of the studies. Accuracy was low in 50% of the cases, and good in just over a third. Limits of detection included the therapeutic range of lithium in all studies. Conclusions Among emerging technologies for lithium TDM, precision and accuracy remain a challenge, particularly for portable devices.

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Section: Resultsmentioning

confidence: 98%

Existing and Emerging Technologies for Therapeutic Monitoring of Lithium

Pedraza-Sanabria,

Dodd,

Giraldo-Cadavid

et al. 2024

J Clin Psychopharmacol

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“…However, the sensitivity and selectivity of these electrodes need to be improved. [4] As shown in Figure 2, Li +selective membranes are classified into conventional and advanced membranes. The conventional membranes include organic (plasticized poly(vinyl chloride) (PVC)) and inorganic (NASICON membrane and metal oxide) membranes [30] have been used for extraction and detection of lithium, while the advanced membranes have been mainly introduced for the extraction of lithium.…”

Section: Conventional Lithium Ion-selective Membranesmentioning

confidence: 99%

“…[1] They have shown promising results for the selectivity and sensitivity of lithium in the presence of interferences ions (Na + , K + , Ca 2+ , Mg 2+ , etc.). [2] Since the fabrication of lithium ISEs, requires the use of more sensitive lithium selective membrane, it is expected that the use of advanced materials such as MOFs membrane, carbon-based membrane, vermiculite membrane, MXene membrane and PET membrane, and their composite with conventional materials [3,4] will improve the sensitivity and selectivity of the Li + -ISEs, which can be investigated in future researches. In addition to the membranes used in lithium extraction, improved lithium-selective membranes have been used in the fabrication of lithium batteries that can improve battery performance.…”

Section: Challenges and Opportunities For Lithium Ion-selective Electrodementioning

confidence: 99%

“…In the biomedical field, the continuous monitoring of Li for mental disorders is critical as the therapeutic effect window of lithium is narrow, and the safe and toxic dose of lithium in serum could vary among patients. [2,4] The therapeutic effect of lithium is related to the serum concentration of the drug, and it must be kept in the range of 6.0 × 10 −4 to 1.2 × 10 −3 m. [4] In the late 1980s, ion-selective electrodes (ISEs) were developed for lithium detection and have been used since then in clinical and environmental applications for real-time and onsite measurement of Li. [5] ISEs are electrochemical ion sensors that convert the activity of a target ion (Li + ) into a measurable electrical potential signal and comprise three main elements, including an electrical conductor substrate, an ion to electron transducer layer, and an ion-selective membrane.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

An Evolving Insight into the Progress of Material Design for Membrane‐Based Electrochemical Lithium Ion Detection

Bakhtiari

Mohammadi

Moazzam

et al. 2021

Adv Materials Inter

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The global shift of energy resources from fossil fuel to renewable energy sources has already begun. The critical energy element of lithium (Li) plays an important role in this energy transition, which is demonstrated by the fast increase in its demand. Rapid and continuous detection of Li has become an important field, as the overexploitation of Li sites, mainly brines, could compromise the nearby aqueous resources that are less salty or contain freshwater. Spent Li‐ion batteries also pose deleterious effects on the environment and aqueous resources. Monitoring of lithium in blood during treating major depressive disorders is also crucial for decreasing the risk of potential lithium toxicity. Li selectivity and stability of membranes as an essential part of any Li sensor is the key to fabricate a high‐performance Li ion‐selective electrode (ISE). Here, the latest progress in Li‐ISEs is covered along with the advanced nanostructured materials that have been recently used for the preparation of Li ion‐selective membranes. The new concepts and technologies that have been created for the purpose of Li mining to be used for Li sensing development are also critically reviewed and highlighted.

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“…The principle of ion mobility spectrometry (IMS) is based on the differences in gaseous ion mobilities of samples, so as to complete the detection of different samples. In situ rapid detection of trace substances often uses the ion mobility spectroscopy technique [15,16]. At present, this technical method is widely used, and has been reported in fast online monitoring of biomolecules, environments, hazardous chemicals etc.…”

Section: Introductionmentioning

confidence: 99%

Rapid measurement of Phthalic acid Ester environmental hormones using ion mobility spectrometry

Liao

Liang

2020

Int. J. Ion Mobil. Spec.

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Ion Mobility Spectroscopy (IMS) is commonly used for in-situ rapid online detection of trace substances at atmospheric pressure. By selecting four types of Phthalic acid Ester (PAE) compounds as the quantitative research objects, studying the effects of the temperature of the mobility tube, the temperature of the sample desorbed heater and the electric field strength of the mobility region on the detection, analysing the microscopic process of ion reaction after the addition of reagent molecules using the Rectilinear Ion Trap Mass Spectrometer (RIT-MS), the paper preliminary studies the product ions of phthalic acid ester, and establish a method for rapid measurement of phthalic acid ester-like environmental hormones with ion mobility spectrometry. With the addition of ammonia reagent molecules, the detection limits of dimethyl phthalate, diethyl phthalate, dibutyl phthalate and butyl benzyl phthalate were 0.08 and 0.1, 0.09, 0.70 ng, respectively, and relative standard deviation RSD of 6 parallel measurements <6.3%. When used for the detection of phthalates in plastics, this method can quickly and easily screen products containing trace PAE-like contaminants.

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Rapid analysis of lithium in serum samples by thermal ionization ion mobility spectrometry

Cited by 6 publications

References 38 publications

Existing and Emerging Technologies for Therapeutic Monitoring of Lithium

Existing and Emerging Technologies for Therapeutic Monitoring of Lithium

An Evolving Insight into the Progress of Material Design for Membrane‐Based Electrochemical Lithium Ion Detection

Rapid measurement of Phthalic acid Ester environmental hormones using ion mobility spectrometry

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