2015
DOI: 10.1016/j.vascn.2014.12.002
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Rapid analysis of hypolipidemic drugs in a live zebrafish assay

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Cited by 45 publications
(33 citation statements)
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“…21 The zebrafish facility at Hunter Biotechnology, Inc. is accredited by the Association for Assessment and Accreditation of Laboratory Animal Care (AAALAC) International. 22 Chemicals and drugs PHZ (lot #: G1324044) and O-dianisidine (lot #: 119-90-4) were purchased from Aladdin company of Shanghai, China. Aspirin and clopidogrel were bought from Sigma-Aldrich, diltiazem hydrochloride injection was from Mitsubishi Tanabe Pharma Corporation, xuanshuantong injection was from Wuzhou Pharmaceutical Corporation, salvianolate injection was from Shanghai Green Valley Pharmaceutical, and astragalus injection was from Chiatai Qingchunbao.…”
Section: Zebrafish Care and Maintenancementioning
confidence: 99%
“…21 The zebrafish facility at Hunter Biotechnology, Inc. is accredited by the Association for Assessment and Accreditation of Laboratory Animal Care (AAALAC) International. 22 Chemicals and drugs PHZ (lot #: G1324044) and O-dianisidine (lot #: 119-90-4) were purchased from Aladdin company of Shanghai, China. Aspirin and clopidogrel were bought from Sigma-Aldrich, diltiazem hydrochloride injection was from Mitsubishi Tanabe Pharma Corporation, xuanshuantong injection was from Wuzhou Pharmaceutical Corporation, salvianolate injection was from Shanghai Green Valley Pharmaceutical, and astragalus injection was from Chiatai Qingchunbao.…”
Section: Zebrafish Care and Maintenancementioning
confidence: 99%
“…11,13,14 In addition, zebrash has been reported to be an excellent model for lipid metabolism, and a useful animal model for the analysis of anti-obesity effects of natural products in a shorter time compared with rodents. [14][15][16][17] Previous researches, which studied the effect of high-fat diet on the body fat accumulation in zebrash, concluded that zebrash is a suitable animal model in research into obesity induced by a diet rich in fat, 14 as well as supported the validity of studying the effects of green tea extract in diet-induced obese zebrash. 11,14 Hence, in the present study, the chemical compositions of MLGT were investigated for the rst time and its health benet, the hypolipidemic bioactivity, was evaluated by using the diet-induced obese zebrash.…”
Section: Introductionmentioning
confidence: 93%
“…Zebrash were placed in the 6-well cell culture plates at a density of 15 zebrash in 4 mL of solution per group for treatment. 16,17 Finally, all zebrash were xed with 4% paraformaldehyde at 4 C overnight and dehydrated by 60% isopropanol for 30 min aer three washes of 1Â phosphatebuffered saline (PBS). In order to compare lipid levels in different experimental groups, ORO staining was conducted.…”
Section: Hypolipidemic Activity Of Mlgt In a Zebrash Modelmentioning
confidence: 99%
“…Some important advantages have been associated with the zebrafish in terms of their use in research, such as the small size, easy maintenance, low cost of breeding, and high reproductive rate. In addition, its genome has already been sequenced, and it presents important homology with mammals, besides the morphological and molecular basis of tissues and organs similar to humans . So, zebrafish is emerging as a predictive vertebrate animal model for in vivo assessment of drug efficacy, toxicity, and safety .…”
Section: Introductionmentioning
confidence: 99%
“…In addition, its genome has already been sequenced, and it presents important homology with mammals, besides the morphological and molecular basis of tissues and organs similar to humans . So, zebrafish is emerging as a predictive vertebrate animal model for in vivo assessment of drug efficacy, toxicity, and safety . Besides, some studies have evaluated the ability of zebrafish larvae at different stages of ripening to generate xenobiotic metabolites .…”
Section: Introductionmentioning
confidence: 99%