Rapid analysis of four Sudan dyes using direct analysis in real time-mass spectrometry

Abstract

A simple direct analysis in a real time-mass spectrometry (DART-MS) method was developed for the rapid determination of four Sudan dyes (I-IV) in chili powder. Simple liquid extraction by hexane without further clean-up was used for sample preparation. DART parameters were systematically optimized to achieve the best detection performance. A DIP-it sampler was used for automatic sampling. The matrix effect was measured by comparing the limit of detection (LOD) in matrix solution with that in pure organic solution.Eventually, the identification of the Sudan dyes was confirmed by MS/MS results and the LODs for four analytes in matrix solution were $0.5 mg mL À1 . The method showed good linearity with correlation coefficients (R 2 ) greater than 0.99 for concentrations ranging from 1 to 20 mg mL À1 . The whole analytical process could be completed within 15 minutes with good recoveries (88-116%) and satisfactory repeatability (<26%, n ¼ 3).

Rapid screening and determination of 11 new psychoactive substances by direct analysis in real time mass spectrometry and liquid chromatography/quadrupole time‐of‐flight mass spectrometry

“…According to the previous report, the working gas type, gas temperature, and the distance between the sampler and the MS inlet always have a great effect on signal intensity. Nitrogen and helium were tested as the working gas, respectively.…”

“…One of its greatest advantages is that it facilitates MS analysis under ambient conditions without or with very simple sample preparation. Direct analysis in real time (DART) is a representative ion source of ambient mass spectrometry that has been commercialized and used for the analysis of various small molecules without sample preparation . Samples could be analyzed in various states including gases, liquids, and solids.…”

“…Some compounds could be detected on various surfaces by DART‐MS, such as concrete, human skin, and fruits . Liquid samples could be analyzed with a Dip‐it method automatically . Because the response from DART is instantaneous, it can provide real‐time information, which makes it very suitable for fast screening and high‐throughput analysis.…”

Fast, easy, cheap, robust and safe method of analysis of Sudan dyes in chilli pepper powder

“…Because of prevalence illegal use of Sudan dyes in foods, and to enhance surveillance, several analytical methods have been proposed in literature ( Ertas et al., 2007 ; Di Anibal et al., 2009 ; Ávila et al., 2011 ; Sun et al., 2011 ; Qi et al., 2011 ; Li et al., 2014 ; Yang et al., 2019 ). Most of the methods proposed to help in this regard took into consideration one or two of the following merits, i.e.…”

New Strategy for Further Improving the Detection Sensitivity of Direct Analysis in Real Time-Mass Spectrometry

“…Besides DESI, direct analysis in real time (DART) is another representative AMS technique, which was proposed by Cody et al in 2005 [5]. This technology has been widely applied in various industries due to its commercialization [6][7][8][9][10]. However, ion transmission efficiency in the ambient pressure was lower than that in vacuum system.…”