Rapid Access to Substituted Indenones through Grignard Reaction and Its Application in the Synthesis of Fluorenones Using Ring Closing Metathesis

Abstract

An efficient, one‐step method has been used to access a variety of substituted indenones in a regiospecific manner by Grignard addition to indene‐1,3‐dione. This method provides straightforward access to natural products such as neo‐lignans and isoampelopsin D analogues. Moreover, diallyl indenones have been synthesized and employed as ring‐closing metathesis (RCM) precursors for the facile synthesis of substituted fluorenone derivatives through an RCM‐aromatization sequence.