Rapid access to new bioconjugates of betulonic acid via click chemistry

Fruit cuticular waxes as a source of biologically active triterpenoids

“…Betulinic acid, usually obtained from the bark of the white birch Betula alba L., has been shown to possess a variety of biological properties including antibacterial, anti-HIV, antimalarial, antiinflammatory and anthelmintic activities (Yogeeswari and Sriram 2005). Betulonic acid and its derivatives have been studied as a new group of agents that reduce the side effects of cytostatics (Sorokina et al 2004; Vasilevsky et al 2011). Therefore, the cuticular waxes of E. globulus fruit contain at least four biologically active triterpene acids (betulinic and betulonic, in addition to oleanolic and ursolic) that may be utilized rather than wasted.…”

Systems Pharmacological Approach of Pulsatillae Radix on Treating Crohn’s Disease

“…Aureusidin (C7; DL = 0.24, OB = 53.42, Caco-2 = 0.07) was reported to have marked antioxidant activity and to be useful for the treatment of several diseases [40, 41], and anemosapogenin (C5; DL = 0.77, OB = 17.87, Caco-2 = 0.07) has antitumor effects [42, 43]. Betulonic acid (C9; DL = 0.78, OB = 16.83, Caco-2 = 0.65) possesses various medical effects, such as antiviral (HIV-1), anticancer, and immunomodulatory activities [44]. Cauloside (C11; DL = 0.4, OB = 6.84, Caco-2 = −0.82) from blue cohosh was reported to inhibit proinflammatory cytokine induction by LPS [45].…”

A reação "click" na síntese de 1,2,3-triazóis: aspectos químicos e aplicações

“…152,153 Como exemplo, há o trabalho de Genazzani e colabora- Vários outros exemplos de síntese de substâncias com atividade biológica construídas utilizando a CuAAC podem ser encontrados na literatura como, por exemplo, compostos com atividades anticâncer, 84,85 antiprotozoária, 86,87 citotóxica, 88 antimicobacteriana, 89 antifúngica, 90 antimalárica, 91 além de diversos inibidores enzimáti-cos, como os da enzima proteína tirosina fosfatase 1B, 92 da enzima glucocerebrosidase, relacionados com a doença de Gaucher, 93 da protease do HIV; 80 de neuraminidases; 94 da enzima nicotinamida fosforribosiltransferase, associados à atividade antitumoral, 95 da enzima a-glucosidase, associada à diabetes mellitus tipo II, 154 dentre outros.…”