Rapid Access to Divergent Fused Polycycles Via One‐Pot A3 Coupling and Intramolecular Diels‐Alder Reaction
Rajashekar Reddy Narra,
Vignesh Gopalakrishnan Unnithan,
Yifan Liu
et al.
Abstract:Divergent nitrogen‐containing fused polycyclic ring systems are constructed from simple starting materials via a one‐pot aldehyde‐alkyne‐amine (A3) coupling and intramolecular Diels‐Alder reaction. This domino reaction directly furnishes linear 5/5/5 and 5/5/6, or nonlinear 5/5/6/5, polycyclic rings containing an oxa‐bridged fused 5/5 bicycle and a 1,6‐enyne substructure. One‐step derivation of the oxa‐bridged 5/5 bicycle leads to a polyfunctionalized 5/5 bicycle with tetrahydrofuran fused back‐to‐back to pyrr… Show more
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