Rapid access to 7-substituted cycloalkylamino and alkylamino analogues of 4-methylcoumarin reveals surprising emitters

Efficient Pd‐catalysed Synthesis of 3‐Amino‐4‐indolylmaleimides and 3‐Amido‐4‐indolylmaleimides

“…Recently, we have developed Buchwald-Hartwig methodologies to install amine and amide auxochromes in various fluorescent molecules. [15][16][17] Taking inspiration from our previous works, we report Buchwald-Hartwig cross-coupling conditions that facilitate the incorporation of amines and amides directly onto the 3-bromo-indolylmaleimide (1) for rapid access of 3-amino-4-indolylmaleimide and 3-amido-4-indolylmaleimide derivatives.…”

“…As a continuation of our ongoing research program in synthesis of indole based biologically active compounds, [11–14] we were interested in the synthesis of 3‐amino‐4‐indolylmaleimide and 3‐amido‐4‐indolylmaleimide from a common precursor for their rapid access. Recently, we have developed Buchwald–Hartwig methodologies to install amine and amide auxochromes in various fluorescent molecules [15–17] . Taking inspiration from our previous works, we report Buchwald–Hartwig cross‐coupling conditions that facilitate the incorporation of amines and amides directly onto the 3‐bromo‐indolylmaleimide (1) for rapid access of 3‐amino‐4‐indolylmaleimide and 3‐amido‐4‐indolylmaleimide derivatives.…”