Rapeseed (canola) oil aggravates metabolic syndrome-like conditions in male but not in female stroke-prone spontaneously hypertensive rats (SHRSP)

Nishikawa, Mai; Ohara, Naoki; Naito, Yukiko; Saito, Yoshiaki; Amma, Chihiro; Tatematsu, Kenjiro; Baoyindugurong, Jinhua; Miyazawa, Daisuke; Hashimoto, Yoko; Okuyama, Harumi

doi:10.1016/j.toxrep.2022.01.011

Cited by 1 publication

(1 citation statement)

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“…One study used Wistar rats and spontaneously hypertensive stroke-prone rats on a canola oil diet that significantly decreased testosterone levels in the testes and plasma. The decrease in plasma testosterone levels was accompanied by an increase in plasma aldosterone [ 70 ]. In bovine adrenal cells, testosterone hemisuccinate stimulates angiotensin membrane binding and aldosterone biosynthesis.…”

Section: Molecular Evidence For the Involvement Of Testosterone In Th...mentioning

confidence: 99%

The role of sex hormones in aldosterone biosynthesis and their potential impact on its mineralocorticoid receptor

Vecchiola,

Uslar,

Friedrich

et al. 2024

Cardiovascular Endocrinology &Amp; Metabolism

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Blood pressure (BP) regulation is a complex process involving various hormones, including aldosterone and its mineralocorticoid receptor. Mineralocorticoid receptor is expressed in several tissues, including the kidney, and plays a crucial role in regulating BP by controlling the sodium and water balance. During different stages of life, hormonal changes can affect mineralocorticoid receptor activity and aldosterone levels, leading to changes in BP. Increasing evidence suggests that sex steroids modulate aldosterone levels. Estrogens, particularly estradiol, mediate aldosterone biosynthesis by activating classical estrogen receptors and the G protein-coupled receptor. Progesterone acts as an anti-mineralocorticoid by inhibiting the binding of aldosterone to the mineralocorticoid receptor. Moreover, progesterone inhibits aldosterone synthase enzymes. The effect of testosterone on aldosterone synthesis is still a subject of debate. However, certain studies show that testosterone downregulates the mRNA levels of aldosterone synthase, leading to decreased plasma aldosterone levels.

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Section: Molecular Evidence For the Involvement Of Testosterone In Th...mentioning

confidence: 99%

The role of sex hormones in aldosterone biosynthesis and their potential impact on its mineralocorticoid receptor

Vecchiola,

Uslar,

Friedrich

et al. 2024

Cardiovascular Endocrinology &Amp; Metabolism

View full text Add to dashboard Cite

show abstract

Rapeseed (canola) oil aggravates metabolic syndrome-like conditions in male but not in female stroke-prone spontaneously hypertensive rats (SHRSP)

Cited by 1 publication

References 61 publications

The role of sex hormones in aldosterone biosynthesis and their potential impact on its mineralocorticoid receptor

The role of sex hormones in aldosterone biosynthesis and their potential impact on its mineralocorticoid receptor

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