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citations
Cited by 17 publications
(31 citation statements)
references
References 59 publications
(65 reference statements)
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“…We previously performed comparative transcriptome analysis of RNA-seq datasets to identify genes that had changed expression more than or equal to fivefold as fibroblasts were induced from proliferative growth to quiescence using serum starvation [ 19 ]. Our analyses demonstrated that 751 genes (not probes) changed expression (428 increased and 323 decreased), and that these genes could be mapped to specific biological pathways, including cell cycle control and mitosis, as well as the complement and coagulation cascade.…”
Section: Resultsmentioning
confidence: 99%
“…We previously performed comparative transcriptome analysis of RNA-seq datasets to identify genes that had changed expression more than or equal to fivefold as fibroblasts were induced from proliferative growth to quiescence using serum starvation [ 19 ]. Our analyses demonstrated that 751 genes (not probes) changed expression (428 increased and 323 decreased), and that these genes could be mapped to specific biological pathways, including cell cycle control and mitosis, as well as the complement and coagulation cascade.…”
Section: Resultsmentioning
confidence: 99%
“…Rapamycin has been extensively linked to cytokine expression and regulation across multiple cell lines. In healthy human foreskin fibroblasts [2DD], rapamycin caused up-regulation of numerous genes, including cytokine genes from the IL-6 signaling cascade, such as IL-6, IL-8, IL-11 , and leukemia inhibitory factor (LIF ; Gillespie et al, 2015 ). Analysis of Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway terms identified a specific enrichment of cytokine-cytokine receptor interactions.…”
Section: Rapamycinmentioning
confidence: 99%
“…Analysis of Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway terms identified a specific enrichment of cytokine-cytokine receptor interactions. Furthermore, transcription factor motif searches of up-regulated promoters and subsequent chromatin immuno-precipitation (ChIP) analyses demonstrated STAT5A/B as likely mediating rapamycin-induced changes in gene expression (Gillespie et al, 2015 ). Compounds that activate SIRT1 function suppress pSTAT5A/B signaling in response to IL-2 and decrease mouse and human T-cell proliferation (Gardner et al, 2013 ).…”
Section: Rapamycinmentioning
confidence: 99%
“…The red circles in panels B and D represent the genomic regions involved in an interaction. demonstrated in a wide variety of cellular processes, including differentiation [31], serum response [39], therapeutic response [21,40] and response to DNA damage [41]. The unique spatial organization of the genome that is seen under these different cellular conditions is hypothesized to be a crucial mechanism driving various nuclear and cellular functions.…”
Section: Introductionmentioning
confidence: 99%
“…B1 < B2 , 19 ( member ( Chr1 , Set1 ) , member ( Chr2 , Set2 ) -> true 20 ; member ( Chr1 , Set2 ) , member ( Chr2 , Set1 ) -> true 21 ) , 22 assertz ( edge ( B1 , B2 , F )) ,…”
mentioning
confidence: 99%