Rapamycin inhibits the in vitro release of soluble interleukin-2 receptor by activated peripheral blood mononuclear cells (PBMC) independently of the mode of activation

Degiannis, Dimitrios; Hornung, Nete

doi:10.1016/0192-0561(95)00077-f

Cited by 4 publications

(5 citation statements)

References 14 publications

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“…IL-2Ra also exists in a soluble form (sIL-2R), which is secreted by activated T cells [17,18]. The release of IL-2R is inhibited by immunosuppressive drugs such as rapamycin and cyclosporin A (CsA) [19].…”

Section: Human Mesenchymal Stem Cells (Mscs) Inhibit T-cell Responsesmentioning

confidence: 99%

Mesenchymal stem cells inhibit lymphocyte proliferation by mitogens and alloantigens by different mechanisms

Rasmusson

Ringdén

Sundberg

et al. 2005

Experimental Cell Research

452

316

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Section: Human Mesenchymal Stem Cells (Mscs) Inhibit T-cell Responsesmentioning

confidence: 99%

Mesenchymal stem cells inhibit lymphocyte proliferation by mitogens and alloantigens by different mechanisms

Rasmusson

Ringdén

Sundberg

et al. 2005

Experimental Cell Research

452

316

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“…Measuring inosine-monophosphate dehydrogenase activity in PBMCs [52] and IL-2 concentrations in PBMC cultures [53] as well as estimating PBMC-blastogenesis [28] would be useful for the tailored-therapy of mycophenolate mofetil in renal transplant recipients. Similar approaches for rapamycin have also been conducted [54,55]. Rapamycin inhibits IL-2 expression through its interaction with the mammalian target of rapamycin (mTOR) protein [48].…”

Section: Organ Transplantationmentioning

confidence: 99%

Cellular pharmacodynamics of immunosuppressive drugs for individualized medicine

Hirano

2007

International Immunopharmacology

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“…sIL-2R is an immunosuppressive inhibitor of the synthesis and secretion of monocytes and activated T cells. It has a regulatory effect on the function of the interleukin-2 (IL-2)/IL-2R system and competes with IL-2R to bind IL-2, inhibit the IL-2 autocrine, and then reduce the IL-2 immune response (11,12). Related studies have confirmed that the upregulation of sIL-2R expression is accompanied by decreased B cell immune function (13).…”

Section: Discussionmentioning

confidence: 99%

Relationship between levels of serum gastric inhibitory polypeptide (GIP), soluble interleukin-2 receptor (sIL-2R), and soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) and disease condition and prognosis of patients with severe acute pancreatitis

Zeng¹,

Xi²,

Yang³

et al. 2021

Ann Palliat Med

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Background: To explore the relationship between levels of serum gastric inhibitory polypeptide (GIP), soluble interleukin-2 receptor (sIL-2R), and soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) and the disease condition and prognosis in patients with severe acute pancreatitis (SAP). Methods: A total of 52 patients with SAP (SAP group) and 50 patients with mild acute pancreatitis (MAP group) admitted to Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China between April 2017 and December 2019 were included in the present study. A further 50 people who had received a healthy physical examination during the same period constituted the healthy control group. The levels of serum GIP, sIL-2R, and sTREM-1 were measured. The levels of serum GIP, sIL-2R, and sTREM-1 were compared among the SAP, MAP and healthy control groups, and the severity of disease (Ranson scoring system) was compared between the SAP and MAP groups. Pearson correlation analysis was used to analyze the correlation between the levels of serum GIP, sIL-2R, and sTREM-1 with the Ranson scores in the SAP group. A receiver operating characteristic (ROC) curve was drawn to evaluate the predictive efficacy of serum GIP, sIL-2R, and sTREM-1 on prognosis.Results: The levels of serum GIP, sIL-2R, and sTREM-1 in the SAP and MAP groups were higher than those in the healthy control group, and the levels in the SAP group were higher than those in the MAP group. The Pearson correlation analysis showed that the levels of serum GIP, sIL-2R, and sTREM-1 in the SAP group were positively correlated with Ranson scores. The levels of serum GIP, sIL-2R, and sTREM-1 in the survival group were lower than those in the deceased group. The ROC curve showed that the best cut-off values of serum GIP, sIL-2R, and sTREM-1 in predicting prognostic survival were 167.040 pg/mL, 70.840 pg/mL, and 128.325 ng/mL, respectively. Conclusions:The levels of serum GIP, sIL-2R, and sTREM-1 are closely related to the severity of illness in patients with SAP and can be used as reference indicators for assessing the onset of SAP and predicting prognosis.Zeng et al. The effect of GIP, sIL-2R and sTREM-1levels in SAP

show abstract

Rapamycin inhibits the in vitro release of soluble interleukin-2 receptor by activated peripheral blood mononuclear cells (PBMC) independently of the mode of activation

Cited by 4 publications

References 14 publications

Mesenchymal stem cells inhibit lymphocyte proliferation by mitogens and alloantigens by different mechanisms

Mesenchymal stem cells inhibit lymphocyte proliferation by mitogens and alloantigens by different mechanisms

Cellular pharmacodynamics of immunosuppressive drugs for individualized medicine

Relationship between levels of serum gastric inhibitory polypeptide (GIP), soluble interleukin-2 receptor (sIL-2R), and soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) and disease condition and prognosis of patients with severe acute pancreatitis

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