Rapamycin inhibits corneal inflammatory response and neovascularization in a mouse model of corneal alkali burn

Li, Jiande; Han, Jiangyuan; Shi, Yu; Liu, Minrui

doi:10.1016/j.exer.2023.109539

Cited by 4 publications

(2 citation statements)

References 43 publications

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“…Among other effects, BMP4 inhibited NET generation through the Noxdependent pathway. MPO is seen in increasing levels in models of alkali burn-related corneal neovascularization, which could be the potential mechanistic link between NETs and corneal neovascularization [63,64]. However, this has not been directly studied yet.…”

Section: Nets In Non-infectious Corneal Diseasesmentioning

confidence: 99%

Unveiling the Web: Exploring the Multifaceted Role of Neutrophil Extracellular Traps in Ocular Health and Disease

Adeeb,

Arabi,

Shah

et al. 2024

JCM

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Neutrophil extracellular traps (NETs) play an essential role in antimicrobial defense. However, NETs have also been shown to promote and mediate a wide spectrum of diseases, including cancer, diabetes mellitus, cardiovascular diseases, and ocular diseases. Data regarding NETs in ocular diseases remain limited. In physiological conditions, NETs protect the eye from debris and cleave proinflammatory cytokines, including several interleukins. On the other hand, NETs play a role in corneal diseases, such as dry eye disease and ocular graft-versus-host disease, where they promote acinar atrophy and delayed wound healing. Additionally, NET levels positively correlate with increased severity of uveitis. NETs have also been described in the context of diabetic retinopathy. Although increased NET biomarkers are associated with an increased risk of the disease, NETs also assist in the elimination of pathological blood vessels and the regeneration of normal vessels. Targeting NET pathways for the treatment of ocular diseases has shown promising outcomes; however, more studies are still needed in this regard. In this article, we summarize the literature on the protective roles of NETs in the eye. Then, we describe their pathogenetic effects in ocular diseases, including those of the cornea, uvea, and retinal blood vessels. Finally, we describe the therapeutic implications of targeting NETs in such conditions.

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Section: Nets In Non-infectious Corneal Diseasesmentioning

confidence: 99%

Unveiling the Web: Exploring the Multifaceted Role of Neutrophil Extracellular Traps in Ocular Health and Disease

Adeeb,

Arabi,

Shah

et al. 2024

JCM

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“…It also inhibits neutrophil and macrophage infiltration and suppresses inflammation-related angiogenesis mediated by MMP2. Furthermore, rapamycin inhibits inflammation induced by corneal alkali burns by regulating angiogenesis through HIF-1α-VEGF and the serum cytokines TNF-α, IL-6, IFN-γ, and GM-CSF [80].…”

Section: Immunosuppressive Drugsmentioning

confidence: 99%

Available Therapeutic Options for Corneal Neovascularization: A Review

Drzyzga,

Śpiewak,

Dorecka

et al. 2024

IJMS

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Corneal neovascularization can impair vision and result in a poor quality of life. The pathogenesis involves a complex interplay of angiogenic factors, notably vascular endothelial growth factor (VEGF). This review provides a comprehensive overview of potential therapies for corneal neovascularization, covering tissue inhibitors of metalloproteinases (TIMPs), transforming growth factor beta (TGF-β) inhibitors, interleukin-1L receptor antagonist (IL-1 Ra), nitric oxide synthase (NOS) isoforms, galectin-3 inhibitors, retinal pigment epithelium-derived factor (PEDF), platelet-derived growth factor (PDGF) receptor inhibitors, and surgical treatments. Conventional treatments include anti-VEGF therapy and laser interventions, while emerging therapies such as immunosuppressive drugs (cyclosporine and rapamycin) have been explored. Losartan and decorin are potential antifibrotic agents that mitigate TGF-β-induced fibrosis. Ocular nanosystems are innovative drug-delivery platforms that facilitate the targeted release of therapeutic agents. Gene therapies, such as small interfering RNA and antisense oligonucleotides, are promising approaches for selectively inhibiting angiogenesis-related gene expression. Aganirsen is efficacious in reducing the corneal neovascularization area without significant adverse effects. These multifaceted approaches underscore the corneal neovascularization management complexity and highlight ideas for enhancing therapeutic outcomes. Furthermore, the importance of combination therapies and the need for further research to develop specific inhibitors while considering their therapeutic efficacy and potential adverse effects are discussed.

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Recent Advances in NLRP3 Inflammasome in Corneal Diseases: Preclinical Insights and Therapeutic Implications

Ge,

Li,

Xia

et al. 2024

The Ocular Surface

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Rapamycin inhibits corneal inflammatory response and neovascularization in a mouse model of corneal alkali burn

Cited by 4 publications

References 43 publications

Unveiling the Web: Exploring the Multifaceted Role of Neutrophil Extracellular Traps in Ocular Health and Disease

Unveiling the Web: Exploring the Multifaceted Role of Neutrophil Extracellular Traps in Ocular Health and Disease

Available Therapeutic Options for Corneal Neovascularization: A Review

Recent Advances in NLRP3 Inflammasome in Corneal Diseases: Preclinical Insights and Therapeutic Implications

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