volume 6, issue 9, P742-754 2014
DOI: 10.18632/aging.100688
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Yuhong Liu, Vivian Diaz, Elizabeth Fernandez, Randy Strong, Lan Ye, Joseph A. Baur, Dudley W. Lamming, Arlan Richardson, Adam B. Salmon

Abstract: The inhibition of mTOR (mechanistic target of rapamycin) by the macrolide rapamycin has many beneficial effects in mice, including extension of lifespan and reduction or prevention of several age-related diseases. At the same time, chronic rapamycin treatment causes impairments in glucose metabolism including hyperglycemia, glucose intolerance and insulin resistance. It is unknown whether these metabolic effects of rapamycin are permanent or whether they can be alleviated. Here, we confirmed that rapamycin cau…

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