Rapamycin Accelerates Axon Regeneration Through Schwann Cell-mediated Autophagy Following Inferior Alveolar Nerve Transection in Rats

Inada, Takanobu; Sato, Hitoshi; Hayashi, Yoshinori; Hitomi, Suzuro; Furukawa, Akihiko; Ando, Masatoshi; Oshima, Eri; Otsuji, Jo; Taguchi, Naoko; Shibuta, Ikuko; Tsuda, Hiromasa; Iwata, Koichi; Shirota, Tatsuo; Shinoda, Masamichi

doi:10.1016/j.neuroscience.2021.05.033

Cited by 8 publications

(3 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In mice, local administration of an autophagy-induced peptide to the axonal injury site significantly suppresses axonal retraction and improves the neuron recovery by stabilizing the microtubule structure (He et al 2016 ). The inhibition of intracellular mTOR signaling pathway via rapamycin administration forms the molecular underpinnings of the blockade of Schwann cell-mediated autophagy, which accelerates the axon regeneration of peripheral nerves in mammalians (Inada et al 2021 ; Li et al 2020 ).…”

Section: Neurite Regeneration Regulated By the Subcellular Structuresmentioning

confidence: 99%

Molecular mechanisms of neurite regeneration and repair: insights from C. elegans and Drosophila

2023

View full text Add to dashboard Cite

The difficulties of injured and degenerated neurons to regenerate neurites and regain functions are more significant than in other body tissues, making neurodegenerative and related diseases hard to cure. Uncovering the secrets of neural regeneration and how this process may be inhibited after injury will provide insights into novel management and potential treatments for these diseases. Caenorhabditis elegans and Drosophila melanogaster are two of the most widely used and well-established model organisms endowed with advantages in genetic manipulation and live imaging to explore this fundamental question about neural regeneration. Here, we review the classical models and techniques, and the involvement and cooperation of subcellular structures during neurite regeneration using these two organisms. Finally, we list several important open questions that we look forward to inspiring future research.

show abstract

Section: Neurite Regeneration Regulated By the Subcellular Structuresmentioning

confidence: 99%

Molecular mechanisms of neurite regeneration and repair: insights from C. elegans and Drosophila

2023

View full text Add to dashboard Cite

show abstract

“…Another related study [19] focused on the inferior alveolar nerve (IAN) instead of the sciatic nerve. In this study, the IAN of Sprague-Dawley rats was transected, and rapamycin, 3-MA or vehicle was administered to the IAN transection (IANX) site once a day for 10 days after surgery.…”

Section: -2-1 Autophagy Responses To Rapamycin and 3-methyladeninementioning

confidence: 99%

Induction of Autophagy and Its Role in Facial Nerve Regeneration after Facial Nerve Injury

Yon,

Kim,

Park

et al. 2023

Preprint

View full text Add to dashboard Cite

Objective: There are currently no known treatment methods for ensuring complete recovery from facial nerve damage. Thus, various basic and clinical studies continue to be conducted to achieve this end. As part of this research, autophagy is being investigated for its role in nerve regeneration. Here, we review the existing literature regarding the involvement and signifi-cance of autophagy in facial nerve injury and regeneration. Methods: A comprehensive litera-ture review was conducted to assess the induction and role of autophagy in facial nerve injury and subsequent regeneration. Results: Studies conducted on rats and mice have demonstrated activation of autophagy and expression of related factors in facial and sciatic nerves. Among the most studied of these factors in relation to degeneration and regeneration of facial and sciatic nerves are LC3II/I, PI3K, mTOR, Beclin-1, ATG3, ATG5, ATG7, ATG9, and ATG12. Conclusion: This analysis indicates that autophagy is involved in the process of nerve regeneration follow-ing facial and sciatic nerve damage. Inadequate autophagy induction or failure of autophagy re-sponses can result in regeneration issues after facial or sciatic nerve damage. Animal studies suggest that autophagy plays an important role in facial and sciatic nerve degeneration and re-generation.

show abstract

“…Another related study [23] focused on the inferior alveolar nerve (IAN) instead of the sciatic nerve. In this study, the IAN of Sprague-Dawley rats was transected, and rapamycin, 3-MA, or vehicle was administered to the IAN transection (IANX) site once a day for 10 days after surgery.…”

Section: Autophagy Responses To Rapamycin and 3-methyladeninementioning

confidence: 99%

Induction of Autophagy and Its Role in Peripheral Nerve Regeneration after Peripheral Nerve Injury

Yon,

Kim,

Park

et al. 2023

IJMS

View full text Add to dashboard Cite

No matter what treatment is used after nerve transection, a complete cure is impossible, so basic and clinical research is underway to find a cure. As part of this research, autophagy is being investigated for its role in nerve regeneration. Here, we review the existing literature regarding the involvement and significance of autophagy in peripheral nerve injury and regeneration. A comprehensive literature review was conducted to assess the induction and role of autophagy in peripheral nerve injury and subsequent regeneration. Studies were included if they were prospective or retrospective investigations of autophagy and facial or peripheral nerves. Articles not mentioning autophagy or the facial or peripheral nerves, review articles, off-topic articles, and those not written in English were excluded. A total of 14 peripheral nerve studies that met these criteria, including 11 involving sciatic nerves, 2 involving facial nerves, and 1 involving the inferior alveolar nerve, were included in this review. Studies conducted on rats and mice have demonstrated activation of autophagy and expression of related factors in peripheral nerves with or without stimulation of autophagy-inducing factors such as rapamycin, curcumin, three-dimensional melatonin nerve scaffolds, CXCL12, resveratrol, nerve growth factor, lentinan, adipose-derived stem cells and melatonin, basic fibroblast growth factor, and epothilone B. Among the most studied of these factors in relation to degeneration and regeneration of facial and sciatic nerves are LC3II/I, PI3K, mTOR, Beclin-1, ATG3, ATG5, ATG7, ATG9, and ATG12. This analysis indicates that autophagy is involved in the process of nerve regeneration following facial and sciatic nerve damage. Inadequate autophagy induction or failure of autophagy responses can result in regeneration issues after peripheral nerve damage. Animal studies suggest that autophagy plays an important role in peripheral nerve degeneration and regeneration.

show abstract

Rapamycin Accelerates Axon Regeneration Through Schwann Cell-mediated Autophagy Following Inferior Alveolar Nerve Transection in Rats

Cited by 8 publications

References 45 publications

Molecular mechanisms of neurite regeneration and repair: insights from C. elegans and Drosophila

Molecular mechanisms of neurite regeneration and repair: insights from C. elegans and Drosophila

Induction of Autophagy and Its Role in Facial Nerve Regeneration after Facial Nerve Injury

Induction of Autophagy and Its Role in Peripheral Nerve Regeneration after Peripheral Nerve Injury

Contact Info

Product

Resources

About