Rap2a Is Negatively Regulated by NF-κB and Contributes to Growth via Wnt Pathway in Shrimp

Wang, Sheng; He, Mingyu; Li, Qinyao; Li, Haoyang; Yin, Bin; He, Jianguo; Li, Chaozheng

doi:10.3389/fmars.2022.942009

Cited by 3 publications

(2 citation statements)

References 37 publications

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“…In recent years, whiteleg shrimp ( Litopenaeus vannamei ) have been farmed on a large scale due to their excellent traits [11] . Today, L. vannamei account for roughly 70% of the world’s cultured shrimp.…”

Section: Introductionmentioning

confidence: 99%

Host and transmission route ofEnterocytozoon hepatopenaei(EHP) from dragonfly to shrimp

Dewangan

Pang

Zhao

et al. 2023

Preprint

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Enterocytozoon hepatopenaei (EHP) is a shrimp pathogen that causes huge economic losses. In the present study, the hosts of EHP were investigated using polymerase chain reaction (PCR) in an aquaculture farm located in Maoming, China. EHP was detected in Litopenaeus vannamei, Penaeus monodon, crab, false mussel, and three dragonfly species (Anax parthenope, Pantala flavescens, and Ischnura senegalensis). In the histopathological examination using hematoxylin–eosin staining, EHP spores were found in nymphs and adult dragonflies naturally infected with EHP that were collected from the shrimp farm. Fluorescence in situ hybridization results showed a positive signal for EHP infection in the fat body of dragonfly nymphs. Immature and mature microsporidian spores and late sporogonial plasmodium were observed in the cytoplasm of dragonfly nymphs using transmission electron microscopy. The transmission of EHP from shrimp to dragonfly nymphs was confirmed via cohabitation challenge experiments in which EHP-free dragonfly nymphs were cohabited with EHP-infected shrimp, and the transmission of EHP from dragonfly nymphs to shrimp was demonstrated via the cohabitation of EHP-infected dragonfly nymphs with EHP-free shrimp and oral administration challenge experiments. This study confirms that dragonflies can act as natural EHP hosts, and a novel EHP horizontal transmission route exists between dragonflies and shrimp.

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Section: Introductionmentioning

confidence: 99%

Host and transmission route ofEnterocytozoon hepatopenaei(EHP) from dragonfly to shrimp

Dewangan

Pang

Zhao

et al. 2023

Preprint

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“…Rap-2a, as part of several signaling cascades, may regulate cytoskeletal rearrangement, cell migration, and cell diffusion (Taira et al, 2004). Through RT-qPCR analysis, Rap-2a was found to have high expression in lymphatic organ, hepatopancrea, intestine and stomach, it was negatively regulated by NF-kB and contributed to growth (Yu et al, 2019;Wang et al, 2022). Additionally, another shrimp growth trait candidate gene, MMD2, was identified by our group (Wang et al, 2020); and studies showed that MMD2 can enhance the retention and activation of Ras protein in Golgi complex, and subsequently lead to the enhancement of ERK (extracellular signal-regulated kinase) signal (Huang et al, 2012).…”

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confidence: 99%

Identification, classification and expression analysis of the Ras superfamily genes in the Pacific white shrimp, Litopenaeus vannamei

Zhang

Yuan

et al. 2023

Front. Mar. Sci.

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The Ras superfamily of small guanosine triphosphatases (GTPases) are a large group of small GTP-binding proteins, which play crucial roles in basic cellular processes in all eukaryotes. In this study, by analyzing the gene structure, temporal and spatial expression patterns, a total of 108 Ras superfamily genes were identified in the genome of the Pacific white shrimp Litopenaeus vannamei. We found these genes included not only the classical Ras GTPase superfamily members, but also some unconventional and novel Ras GTPase proteins, which have unknown functions and unique expression patterns. All Ras superfamily genes of L. vannamei were highly conserved within the core G domain and closely related in phylogeny, but they might have two different evolutionary origins. In addition, different Ras GTPase genes exhibited distinct expression patterns in different tissues, development/molting stages and WSSV infection samples of L. vannamei, suggesting that they may have a high functional specialization, and play important roles in regulating the biological processes of cell differentiation, growth and development, immune response, etc. This study provides important clues for the structure, classification, evolution and function of Ras superfamily in shrimp.

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Recent Research Advances on the Hippo‐Yki Pathway of Crustaceans: Current Knowledge and Potential Applications in Crustacean Aquaculture

Yang,

Gan,

Deng

et al. 2024

Reviews in Aquaculture

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The Hippo‐YAP/Yki pathway is critical for the regulation of physiological responses in various biological processes from invertebrates to mammals. Crustaceans, in particular shrimp and crabs, are important food sources worldwide. In response to the needs of crustacean aquaculture and disease control, the regulatory mechanisms of crustacean life activities, especially immunity, have been increasingly emphasized. Emerging clues suggest that Hippo‐Yki pathway is important for immunity and regeneration in crustaceans. In this review, the structure, activation pattern, response mechanism to pathogen invasion, and crosstalk with other signaling cascades of the Hippo‐Yki pathway in aquaculture crustaceans are summarized and its similarities and differences with those in mammals and Drosophila are investigated. Based on this, the roles of the Hippo‐Yki pathway in crustacean immune response and limb regeneration are further discussed, and the application potential of strategies pharmacologically or biologically targeting this pathway for crustacean disease control and breeding is theoretically explored.

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Rap2a Is Negatively Regulated by NF-κB and Contributes to Growth via Wnt Pathway in Shrimp

Cited by 3 publications

References 37 publications

Host and transmission route ofEnterocytozoon hepatopenaei(EHP) from dragonfly to shrimp

Host and transmission route ofEnterocytozoon hepatopenaei(EHP) from dragonfly to shrimp

Identification, classification and expression analysis of the Ras superfamily genes in the Pacific white shrimp, Litopenaeus vannamei

Recent Research Advances on the Hippo‐Yki Pathway of Crustaceans: Current Knowledge and Potential Applications in Crustacean Aquaculture

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