RANTES and MIP-1α production by T lymphocytes, monocytes and NK cells from nonagenarian subjects

Mariani, Erminia; Pulsatelli, Lia; Neri, Simona; Dolzani, Paolo; Meneghetti, Alessandra; Silvestri, Tania; Ravaglia, Giovanni; Forti, Paola; Cattini, Luca; Facchini, Andrea

doi:10.1016/s0531-5565(01)00187-5

Cited by 76 publications

(36 citation statements)

References 23 publications

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“…However, a marked early decrease in IFN-␥ secretion in response to IL-2, which can be overcome by increasing the incubation time, has also been shown [63] . The production of chemokines by NK cells is decreased in old subjects in response to IL-2 or IL-12 [64][65][66] . Considering that CD56 dim NK cells can produce high amounts of IFN-␥ , and whereas chemokines are mainly produced by CD56 bright NK cells, the decrease in this subset in the elderly can explain their decreased production by NK cells associated with aging.…”

Section: Effect Of Aging On Nk Cell Response To Cytokinesmentioning

confidence: 99%

Immunosenescence of Human Natural Killer Cells

et al. 2011

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Natural killer (NK) cells are a key component of innate immunity involved not only in the elimination of virus-infected or tumor cells but also in the regulation of the immune response by producing cytokines and chemokines that can activate other cellular components of innate and adaptive immunity. NK cell subsets are differentially affected by aging. Whereas CD56^bright cells are decreased in healthy elderly individuals, the CD56^dim subset is expanded. The expression of CD57, a marker of highly differentiated NK cells, is increased in the elderly; this supports the notion that a remodeling process of NK cell subsets occurs in aging with a gradual decrease in more immature CD56^bright NK cells and an increase in highly differentiated CD56^dim CD57+ NK cells. This NK cell redistribution can explain many of the phenotypic and functional changes in NK cells associated with healthy aging such as decreased proliferation and the maintenance of CD16-dependent cytotoxicity.

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Section: Effect Of Aging On Nk Cell Response To Cytokinesmentioning

confidence: 99%

Immunosenescence of Human Natural Killer Cells

et al. 2011

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“…Cytotoxicity, cytokine and chemokine production, proliferation and receptor expression are also adversely affected with age (Camous et al, 2012). CD56 bright NK cells in the aged produce less chemokines in response to the activating cytokines IL-2 and IL-12 (Mariani et al, 2002a;Mariani et al, 2002b). In contrast, CD16 the low-affinity IgG receptor (FcRIII-A) involved in antibody dependent cell cytotoxicity is not affected by ageing, although interestingly cord blood and infant NK cells display very low CD16-dependent cytotoxicity compared with healthy adults (Le Garff-Tavernier et al, 2010;Solana et al, 1999;Solana and Mariani, 2000).…”

Section: Nk Cells In Ageingmentioning

confidence: 99%

Nutrition, diet and immunosenescence

Maijó

Clements

Ivory

et al. 2014

Mechanisms of Ageing and Development

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Ageing is characterized by immunosenescence and the progressive decline in immunity in association with an increased frequency of infections and chronic disease. This complex process affects both the innate and adaptive immune systems with a progressive decline in most immune cell populations and defects in activation resulting in loss of function. Although host genetics and environmental factors, such as stress, exercise and diet can impact on the onset or course of immunosenescence, the mechanisms involved are largely unknown. This review focusses on identifying the most significant aspects of immunosenescence and on the evidence that nutritional intervention might delay this process, and consequently improve the quality of life of the elderly. We would like to thank the reviewers for their careful review of our manuscript, which has been revised accordingly. Below, we have provided a point-by-point reply to the issues raised: AbstractAgeing is characterized by immunosenescence and the progressive decline in immunity in association with an increased frequency of infections and chronic disease. This complex process affects both the innate and adaptive immune systems with a progressive decline in most immune cell populations and defects in activation resulting in loss of function. Although host genetics and environmental factors, such as stress, exercise and diet can impact on the onset or course of immunosenescence, the mechanisms involved are largely unknown. This review focusses on identifying the most significant aspects of immunosenescence and on the evidence that nutritional intervention might delay this process, and consequently improve the quality of life of the elderly.

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“…The data regarding cytokine and chemokine secretion are ambiguous in several studies using human monocytes from aged or young individuals activated in vitro with mitogens or LPS. Although the majority of the studies indicate an increase in the levels of pro-inflammatory factors such as IL-6 and IL-8 (Ershler et al ., 1993;Clark & Peterson, 1994;O'Mahony et al ., 1998;Roubenoff et al ., 1998;Sadeghi et al ., 1999;Hasegawa et al ., 2000;Mariani et al ., 2002), others find decreased levels (Gon et al ., 1996;Beharka et al ., 2001) or no changes at all (Ahluwalia et al ., 2001). Differences in the genetic heterogeneity and health status of the test population, in addition to the experimental and assay conditions, may all contribute to the discrepancy in these results.…”

Section: Cytokine and Chemokine Secretionmentioning

confidence: 99%

Innate immunity in aging: impact on macrophage function

et al. 2004

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SummaryInnate and adaptive immune functions decline with age, leading to increased susceptibility to infectious diseases and cancer, and reduced responses to preventive vaccination in the elderly population. Macrophages function as 'pathogen sensors' and play an important role in the initiation of inflammatory responses, elimination of pathogens, manipulation of the adaptive immune response and reparation of damaged tissue. In this paper, we review the literature addressing the impact of aging on the macrophage population.

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RANTES and MIP-1α production by T lymphocytes, monocytes and NK cells from nonagenarian subjects

Cited by 76 publications

References 23 publications

Immunosenescence of Human Natural Killer Cells

Immunosenescence of Human Natural Killer Cells

Nutrition, diet and immunosenescence

Innate immunity in aging: impact on macrophage function

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