RANTES: a new prostaglandin dependent endogenous pyrogen in the rat

Tavares, Eva; Miñano, F.J.

doi:10.1016/s0028-3908(00)00073-3

Cited by 29 publications

(17 citation statements)

References 32 publications

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“…A key event in the initiation of fever in response to acute bacterial infection is the induction and release of endogenous pyrogens (i.e., IL-1, IL-6, IL-8, RANTES, and MIPs) by polymorphonuclear and mononuclear leukocytes into the bloodstream (19,23,32,40,41,44). Normal leukocytes contain no detectable pyrogen and do not produce any during in vitro incubation.…”

Section: Discussionmentioning

confidence: 99%

Circulating Inflammatory Mediators during Start of Fever in Differential Diagnosis of Gram-Negative and Gram-Positive Infections in Leukopenic Rats

Tavares

Maldonado

Ojeda

et al. 2005

Clin Vaccine Immunol

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Gram-negative and gram-positive infections have been considered the most important causes of morbidity and mortality in patients with leukopenia following chemotherapy. However, discrimination between bacterial infections and harmless fever episodes is difficult. Because classical inflammatory signs of infection are often absent and fever is frequently the only sign of infection, the aim of this study was to assess the significance of serum interleukin-6 (IL-6), IL-10, macrophage inflammatory protein-2 (MIP-2), procalcitonin (PCT), and C-reactive protein (CRP) patterns in identifying bacterial infections during start of fever in normal and cyclophosphamide-treated (leukopenic) rats following an injection of lipopolysaccharide (LPS) or muramyl dipeptide (MDP) as a model for gram-negative and gram-positive bacterial infections. We found that, compared to normal rats, immunosuppressed animals exhibited significantly higher fevers and lesser production of all mediators, except IL-6, after toxin challenge. Moreover, compared to rats that received MDP, both groups of animals that received an equivalent dose of LPS showed significantly higher fevers and greater increase in serum cytokine levels. Furthermore, in contrast to those in immunocompetent rats, serum levels of IL-6 and MIP-2 were not significantly changed in leukopenic animals after MDP injection. Other serum markers such as PCT and CRP failed to discriminate between bacterial stimuli in both groups of animals. These results suggest that the use of the analyzed serum markers at an early stage of fever could give useful information for the clinician for excluding gram-negative from gram-positive infections.

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Section: Discussionmentioning

confidence: 99%

Circulating Inflammatory Mediators during Start of Fever in Differential Diagnosis of Gram-Negative and Gram-Positive Infections in Leukopenic Rats

Tavares

Maldonado

Ojeda

et al. 2005

Clin Vaccine Immunol

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“…Indeed, the action of RANTES/CCL5 is characterized by an immediate and an intense dose-related fever following injection. This effect is prevented by pretreatment with a prostaglandin synthesis inhibitor (Tavares & Minano 2000). The magnitude of the febrile response induced by RANTES/CCL5 is greater than that produced with equipotent dose of MIP-1b/CCL4.…”

Section: Chemokines and Body Temperaturementioning

confidence: 93%

Chemokines and chemokine receptors in the brain: implication in neuroendocrine regulation

Callewaere

Banisadr²,

Rostène³

et al. 2007

Journal of Molecular Endocrinology

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Chemokines are small secreted proteins that chemoattract and activate immune and non-immune cells both in vivo and in vitro. In addition to their well-established role in the immune system, several recent reports have suggested that chemokines and their receptors may also play a role in the central nervous system (CNS). The best known central action is their ability to act as immuno-inflammatory mediators. Indeed, these proteins regulate leukocyte infiltration in the brain during inflammatory and infectious diseases. However, we and others recently demonstrated that they are expressed not only in neuroinflammatory conditions, but also constitutively by different cell types including neurons in the normal brain, suggesting that they may act as modulators of neuronal functions. The goal of this review is to highlight the role of chemokines in the control of neuroendocrine functions. First, we will focus on the expression of chemokines and their receptors in the CNS, with the main spotlight on the neuronal expression in the hypothalamo-pituitary system. Secondly, we will discuss the role -we can now suspect -of chemokines and their receptors in the regulation of neuroendocrine functions. In conclusion, we propose that chemokines can be added to the well-described neuroendocrine regulatory mechanisms, providing an additional fine modulatory tuning system in physiological conditions.

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“…With this system, core body temperature and gross locomotor activity can be monitored continuously without restricting the animals’ freedom of movement or access to food. Procedures for implanting guide cannulae and transmitters were reported previously [15, 27, 28]. All animals were allowed to recover from surgery for a minimum of 5–7 days and then housed individually.…”

Section: Methodsmentioning

confidence: 99%

Procalcitonin N-Terminal Peptide Causes Catabolic Effects via the Hypothalamus and Prostaglandin-Dependent Pathways

Tavares¹,

Miñano²

2008

Neuroendocrinology

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Recent evidence suggests that the free amino-terminal fragment of procalcitonin (N-PCT) plays a role in the central control of feeding behavior and energy homeostasis. However, little is known about the mechanisms through which N-PCT works. Here we report that intracerebroventricular administration of N-PCT to free-feeding male rats induced a significant decrease of longer-term food intake and body weight gain. Conversely, N-PCT increased body temperature. We also show that intracerebroventricular administration of N-PCT induced a marked neuronal activation in key thermoregulatory and feeding areas of the hypothalamus. We further show that N-PCT increases the responsiveness of proopiomelanocortin anorexigenic neurons in the arcuate nucleus of the hypothalamus, and that stimulation of the de novo synthesis of prostaglandins is crucial for the central effects induced by N-PCT. Results support the role of N-PCT to the central control of feeding behavior and suggest that N-PCT, acting probably through the eicosanoid cyclooxygenase pathway, may act as a signaling molecule in the hypothalamus by regulating the activity of anorexigenic neurons in the hypothalamus.

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RANTES: a new prostaglandin dependent endogenous pyrogen in the rat

Cited by 29 publications

References 32 publications

Circulating Inflammatory Mediators during Start of Fever in Differential Diagnosis of Gram-Negative and Gram-Positive Infections in Leukopenic Rats

Circulating Inflammatory Mediators during Start of Fever in Differential Diagnosis of Gram-Negative and Gram-Positive Infections in Leukopenic Rats

Chemokines and chemokine receptors in the brain: implication in neuroendocrine regulation

Procalcitonin N-Terminal Peptide Causes Catabolic Effects via the Hypothalamus and Prostaglandin-Dependent Pathways

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