Ranolazine attenuates mechanical allodynia associated with demyelination injury

Extradural Thoracic Spinal Lesion Presenting as Low Back and Leg Pain

“…The results of their in vitro experiments using single unit recording techniques provide important evidence to support earlier observations that ranolazine's modulation of the late sodium current plays an important role in membrane stabilization and that through this mechanism not only contributes to its cardioprotective effect [2][3][4][5] but to the alleviation of allodynia induced by doxorubicin. These observations correlate nicely with our in vivo observations of ranolazine's attenuation of mechanical allodynia and slowed nerve conduction produced by intraneural injection of doxorubicin [6] and add additional support for the mechanisms that we postulated may contribute to our findings. Together, this collection of studies provides a strong example of how a multidimensional approach to the evaluation of a problem contributes to the validation of an idea and to the evolution of the understanding of biological processes.…”

“…Stillerman et al previously published a literature review regarding the management of 82 patients with symptomatic herniated thoracic disks between 1971 and 1995 that were surgically treated by the authors [6]. In 34 men and 37 women with a mean age of 48 years, they found that the most common sites of disk hernation requiring surgery were from T-8 to T-11 (66%).…”

“…The platelet function test we used, the Accumetric Ver-ifyNowV R PRUTest, has been used to guide neuraxial block placement in patients previously on clopidogrel [6]. Removal of an epidural catheter in patients receiving anti-platelet agents has been described with other platelet function tests, including the Multiple Platelet Function Analyzer TM [7], PFA-100 and thromboelastometry [8,9].…”