RANK/RANKL Expression Is Induced by Cardiac Surgical Operation

Krejsek, Jan; Koláčková, Martina; Lonský, Vladimír; Kudlová, Manuela; Mandak, Jiri; Kuneš, P; Jankovicova, Karolina; Vlášková, Dana; Andrýs, Ctirad

doi:10.14712/18059694.2016.121

Cited by 2 publications

(4 citation statements)

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“…The 'naïve' T lymphocytes have a low proliferative ability after polyclonal stimulation in comparison with the adults. They produced a very small amount of several cytokines; especially a lack of IL-5 was observed [16][17][18][19]. So far, according to our best knowledge no one has obtained any data about the immunoreactivity against diabetogenic autoantigens of the naïve neonatal immune system.…”

Section: Figurementioning

confidence: 99%

“…Protein microarray seems to be a useful tool to characterize a risk pattern of the immune response for T1D also in newborns. onset of T1D, when only few b-cells remain, the Th1like response vanishes and remains suppressed in newly diagnosed T1D patients [10,[13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

“…Especially the lack of Th1 subset cytokines can be observed as well as inadequate interaction with B lymphocytes. The immunological balance of the mother as well as of the foetus is slightly weighted in favour of Th2 [16][17][18][19][20][21][22]. Interestingly, cord blood also includes a subset of CD3 ) CD8 + lymphocytes displaying NK activity that is undetectable in peripheral blood of adults.…”

Section: Introductionmentioning

confidence: 99%

“…Interestingly, cord blood also includes a subset of CD3 ) CD8 + lymphocytes displaying NK activity that is undetectable in peripheral blood of adults. These cells are supposed to be representing the stage between thymocytes and mature T lymphocytes [16][17][18][19][20][21][22].…”

Section: Introductionmentioning

confidence: 99%

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Cord Blood Cytokine Profile Detection in Neonates with T1D Parents – Monitoring of Cellular Auto‐reactivity Using Protein Microarray

et al. 2007

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Type 1 diabetes (T1D) is a great medical challenge and its incidence rises rapidly. T lymphocytes and their cytokine production are supposed to play a major role in T1D development. So far, there is no potent tool to recognize the early signs of cellular auto‐reactivity which leads to β‐cell damage. The naïve immune system of the newborn (not yet influenced by external factors) can be used as an important model for T1D pathogenesis studies. Cord blood samples of 22 healthy neonates born at term to a diabetic parent (T1DR) and 15 newborns with no family history of any autoimmune disease (controls) were collected. Determination of 23 cytokines was performed before and after the stimulation with diabetogenic autoantigens using protein microarray. We observed lower basal production of all detected cytokines in the T1DR group – granulocyte/macrophage colony‐stimulating factor (GM‐CSF) (P = 0.025), growth regulated protein (GRO) (P = 0.002), GRO‐α (P = 0.027), interleukin (IL)‐1‐α (P = 0.051), IL‐3 (P = 0.008), IL‐7 (P = 0.027), IL‐8 (P = 0.042), monocyte chemoattractant proteins (MCP)‐3 (P = 0.022), monokine‐induced by IFN‐γ (MIG) (P = 0.034) and regulated upon activation normal T‐cell express sequence (RANTES) (P = 0.004). Exclusively lower post‐stimulative levels of G‐CSF (P = 0.030) and GRO‐α (P = 0.04) were observed in controls in comparison with the basal levels. A significant post‐stimulative decrease in G‐CSF (P = 0.030) and MCP‐2 (P = 0.009) levels was observed in controls in comparison with T1DR neonates. We also observed the interesting impact of the risky genotype on the protein microarray results. Protein microarray seems to be a useful tool to characterize a risk pattern of the immune response for T1D also in newborns.

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Section: Figurementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Cord Blood Cytokine Profile Detection in Neonates with T1D Parents – Monitoring of Cellular Auto‐reactivity Using Protein Microarray

et al. 2007

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OPG/RANK/RANKL Axis in Stabilization of Spontaneously Restored Sinus Rhythm in Permanent Atrial Fibrillation Patients after Mitral Valve Surgery

Liu¹,

Cao

Zhu³

et al. 2012

Cardiology

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Objective: To investigate the expression of the osteoprotegerin (OPG)/receptor activator of nuclear factor-ĸB (RANK)/RANK ligand (RANKL) axis in the stabilization of spontaneously restored sinus rhythm (SR) in permanent atrial fibrillation (AF) patients after mitral valve (MV) surgery and study its clinical significance. Methods: Clinical data, biopsies of right atrial appendages were collected from 135 permanent AF patients who spontaneously restored SR after conventional isolated MV replacement. A comparison was made between patients who had recurrence of AF within 7 days and patients with persistent SR for more than 7 days. Results: AF patients had an increased expression of RANK, RANKL, and the RANKL/OPG ratio compared to SR patients, and the degree of fibrosis was lower in SR compared to AF in the atria. Moreover, the expressions of RANK, RANKL, and the RANKL/OPG ratio were positively correlated with the degree of fibrosis. Conclusion: These findings suggest that the OPG/RANK/RANKL axis plays important roles in the stabilization of restored SR after MV surgery by stimulating AF-related atrial remodeling in AF patients.

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RANK/RANKL Expression Is Induced by Cardiac Surgical Operation

Abstract: The expression of both RANK and RANKL molecules is significantly enhanced on monocytes of "miniinvasive on-pump" cardiac surgical patients.

Cited by 2 publications

References 20 publications

Cord Blood Cytokine Profile Detection in Neonates with T1D Parents – Monitoring of Cellular Auto‐reactivity Using Protein Microarray

Cord Blood Cytokine Profile Detection in Neonates with T1D Parents – Monitoring of Cellular Auto‐reactivity Using Protein Microarray

OPG/RANK/RANKL Axis in Stabilization of Spontaneously Restored Sinus Rhythm in Permanent Atrial Fibrillation Patients after Mitral Valve Surgery

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