RANK is essential for osteoclast and lymph node development

Dougall, William C.; Glaccum, Moira; Charrier, K; Rohrbach, K; Brasel, Kenneth; Smedt, Thibaut De; Daro, Elizabeth; Smith, Jeremy A.; Tometsko, Mark; Maliszewski, Charles R.; Armstrong, Allison; Shen, Victor; Bain, Steven D.; Cosman, David; Anderson, D; Morrissey, Philip J.; Peschon, Jacques J.; Schuh, JoAnn C. L.

doi:10.1101/gad.13.18.2412

Cited by 1,308 publications

(998 citation statements)

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“…The TNFR family plays an important role, for example, in lymph node organogenesis and osteoclast differentiation (Neumann et al, 1996;Dougall et al, 1999;Pasparakis et al, 2000). TNK1 is catalytically active upon expression even in the absence of additional stimuli.…”

Section: Discussionmentioning

confidence: 99%

Thirty-eight-negative kinase 1 (TNK1) facilitates TNFα-induced apoptosis by blocking NF-κB activation

et al. 2007

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Section: Discussionmentioning

confidence: 99%

Thirty-eight-negative kinase 1 (TNK1) facilitates TNFα-induced apoptosis by blocking NF-κB activation

et al. 2007

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“…Although LN development occurs in RelB knockout mice, the nodes are small at birth and are resorbed perinatally. In addition to LTbR, knockouts of RANK, which likewise signals through the noncanonical pathway, also lack peripheral LNs (Dougall et al, 1999).…”

Section: Secondary Lymphoid Organsmentioning

confidence: 99%

NF-κB and the immune response

2006

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“…The Ig superfamily member, CD40 and Toll-like receptors are receptors known to signal through TRAF6, yet none of those TNFR are implicated in the regulation of DC homeostasis. Another TNFR family member, TNF-related, activation-induced cytokine (TRANCE) receptor (also called RANK), which signals through TRAF6 is expressed by DC and promotes DC survival [42]. However, RANK-deficient mice do not exhibit any DC abnormalities, but are deficient in lymphoid organogenesis and osteoclast development.…”

Section: Noncanonical Nfκb Signaling Cascade Regulates DC Homeostasismentioning

confidence: 99%

The TNF receptor and Ig superfamily members form an integrated signaling circuit controlling dendritic cell homeostasis

Trez

Ware

2008

Cytokine & Growth Factor Reviews

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Dendritic cells (DC) constitute the most potent antigen presenting cells of the immune system, playing a key role bridging innate and adaptive immune responses. Specialized DC subsets differ depending on their origin, tissue location and the influence of trophic factors, the latter remain to be fully understood. Stromal cell and myeloid-associated Lymphotoxin-β receptor (LTβR) signaling is required for the local proliferation of lymphoid tissue DC. This review focuses the LTβR signaling cascade as a crucial positive trophic signal in the homeostasis of DC subsets. The noncanonical coreceptor pathway comprised of the Immunoglobulin (Ig) superfamily member, B and T lymphocyte attenuator (BTLA) and TNFR superfamily member, Herpesvirus entry mediator (HVEM) counter regulates the trophic signaling by LTβR. Together both pathways form an integrated signaling circuit achieving homeostasis of DC subsets.Keywords dendritic cells; homeostasis; TNF superfamily; cosignaling; lymphotoxin; herpesvirus entry mediator Dendritic CellsDendritic cells (DC) originate from hematopoietic precursors and can be divided in several subsets depending on their anatomical location, surface phenotype and function. For example, two broad classes of DC are the peripheral migratory DC and the lymphoid tissue-resident DC [1]. The migratory DC, i.e. the dermal DC and Langerhans cells, can be considered as sentinels of the immune system as they form a sensing barrier in peripheral tissues at the interface with environment. The lymphoid tissue-resident DC include the splenic and thymic DC.Dendritic cells are specialized in the capture, transport, processing and presentation of antigens. In the presence of a microbial stimulus, these steps are associated with further DC differentiation (maturation) characterized by upregulation of costimulatory and major histocompatibility complex (MHC) molecules. As DC become activated they migrate to or Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. Both spleen and lymph node lymphoid tissue-resident DC possess a half-life of about three days. Despite their rapid turnover, little is known about the factors controlling immediate precursors and homeostasis in vivo. In earlier studies, CD8α expression was used to distinguish between "lymphoid" and "myeloid" DC. However, more recent experiments showed that different DC subsets could differentiate from both lymphoid and myeloid precursors [6,7]. CD8α marker remains very useful to discriminate between subsets, but no longer defines a subset origin. Recently, the group of Shortman provided in vivo and in vitro evidence fo...

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RANK is essential for osteoclast and lymph node development

Cited by 1,308 publications

References 62 publications

Thirty-eight-negative kinase 1 (TNK1) facilitates TNFα-induced apoptosis by blocking NF-κB activation

Thirty-eight-negative kinase 1 (TNK1) facilitates TNFα-induced apoptosis by blocking NF-κB activation

NF-κB and the immune response

The TNF receptor and Ig superfamily members form an integrated signaling circuit controlling dendritic cell homeostasis

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