Ranibizumab Prefilled Syringes: Benefits of Reduced Syringe Preparation Times and Less Complex Preparation Procedures

Souied, Eric H.; Nghiem-Buffet, Sylvia; Leteneux, Claudia; Bayer, Sascha; Derveloy, Audrey; Sagkriotis, Alexandros; Becker, Guido; Cohen, Salomon-Yves

doi:10.5301/ejo.5000629

Cited by 22 publications

(13 citation statements)

References 15 publications

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“…Besides, the injected volume and dose adjustment could be made more accurately. 17,18 However, due to economic and health policies, access to treatment with pre-filled injectors may not be easy.…”

Section: Discussionmentioning

confidence: 99%

The influence of dead spaces and the designs of injectors on the amount of drug dose in intra-vitreal injection

Havuz

Havuz²,

Gökmen

2020

European Journal of Ophthalmology

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Aim: To evaluate the dead spaces resulting from different designs of the insulin injectors used for intravitreal injections and the amounts of drug doses. Methods: In the study, five different brands of sterile insulin injectors of 1 mL were used for the test. The weight of the injectors was determined before and after filling the injectors with 0.05 and 0.1 mL distilled water. The weight of the injectors was measured with and without the needle after the water within the injectors had been taken out and weight differences were measured. The difference between the intended amount of fluid to be thrown out and the weight of the fluid remaining in the injector was calculated as percent error. Results: After throwing out 0.05 mL distilled water from the injector, weights of the Beybi®, Traf®, Becton Dickinson®, Ayset®, and Setojet® brands of injectors with 30 G needle were detected to increase the mean 0.0220 ± 0.006 g, 0.0208 ± 0.008 g, 0.0355 ± 0.016 g, 0.0219 ± 0.017 g, and 0.0150 ± 0.007 g, respectively compared to the weights of the dry injectors. The 0.1 mL injector group was found to be mean 0.0350 ± 0.014 g, 0.0264 ± 0.008 g, 0.0405 ± 0.015 g, 0.0272 ± 0.013 g, and 0.0245 ± 0.014 g, respectively. The maximum increase due to the dead spaces in the injectors was found in the Becton Dickinson® injector, both in the 0.05 mL and the 0.1 mL groups ( p < 0.000). Conclusion: The injector designs may affect the dose of IVI required to be given. More correct amounts of drugs may be administered via the intra-vitreal route through designs that reduce the dead spaces at the end part of the injector and between the inner wall and the plunger.

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Section: Discussionmentioning

confidence: 99%

The influence of dead spaces and the designs of injectors on the amount of drug dose in intra-vitreal injection

Havuz

Havuz²,

Gökmen

2020

European Journal of Ophthalmology

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“…The ready-to-use syringe simplifies the injection considerably, so that in some countries, injections by non-ophthalmologists can also be carried out more easily, quickly and safely. 54,55 However, glass syringes such as the approved ranibizumab pre-filled syringe are prone to breakage and have a relatively large weight compared to plastic syringes.…”

Section: Options To Reduce Contamination and Side Effectsmentioning

confidence: 99%

<p>Issues with Intravitreal Administration of Anti-VEGF Drugs</p>

Schargus¹,

Фрингс²

2020

OPTH

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Purpose: To provide an update of summary of risk factors and side effects of long-term use and contamination of intravitreal anti-VEGF injections. Methods: We reviewed relevant publications of the topic of contamination of anti-VEGF injections and long-term side effects due to this reason. Results: Due to the long-term use of anti-VEGF drugs and the higher number of injections worldwide, various studies have shown side effects in recent years, ranging from increased intraocular pressure to visual disturbing silicone oil vesicles in the vitreous cavity. Several studies have demonstrated that both the drug and the processing, storage, environmental factors and the material and design of the syringes have a decisive influence on these side effects.Conclusion: The risks of deposits from syringes in the eye can be significantly reduced by various optimizations in transport, storage and syringe and cannula selection.

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“…By eliminating a number of steps in the previous injection preparation, reduced injection time is a significant advantage to using the ranibizumab PFS. Souied et al15 demonstrated a 27%–39% reduction in syringe preparation time when using the PFS rather than the standard ranibizumab vial. Likewise, a previous multicenter study comparing preparation times using traditional syringes vs the PFS revealed that the use of a PFS saved an average of 25.5 seconds 16.…”

Section: Reduced Injection Timementioning

confidence: 99%

<p>Prefilled syringes for intravitreal drug delivery</p>

Sassalos¹,

Paulus²

2019

OPTH

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Intravitreal injections of anti-vascular endothelial growth factor (VEGF) medications play an increasingly critical role in numerous retinal vascular diseases. Initially, anti-VEGF medications came in vials that had to be drawn up by the physician into a syringe for administration. In 2018, the US Food and Drug Administration (US FDA) approved the ranibizumab 0.3 mg prefilled syringe (PFS), and in October 2016, the US FDA approved the ranibizumab 0.5 mg PFS. This article discusses the advantages of the PFS, including reduced injection time, possible reduced risk of endophthalmitis, reduction in intraocular air bubbles and silicone oil droplets, and improved precision in the volume and dose of intravitreal ranibizumab administered, along with possible disadvantages. Implications of the innovation of the PFS on intravitreal injection technique and clinical practice pattern are discussed and reviewed.

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Ranibizumab Prefilled Syringes: Benefits of Reduced Syringe Preparation Times and Less Complex Preparation Procedures

Abstract: Syringe preparation times for ranibizumab intravitreal injections are significantly shorter with the PFS than with the vial. The time saved by using the PFS may benefit physicians and nurses, and the simplicity of the injection preparation process with the PFS is advantageous.

Cited by 22 publications

References 15 publications

The influence of dead spaces and the designs of injectors on the amount of drug dose in intra-vitreal injection

The influence of dead spaces and the designs of injectors on the amount of drug dose in intra-vitreal injection

<p>Issues with Intravitreal Administration of Anti-VEGF Drugs</p>

<p>Prefilled syringes for intravitreal drug delivery</p>

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