Ranibizumab in the treatment of choroidal neovascularization on the border of an inferior staphyloma associated with tilted disc syndrome

Arias, Luís; Monés, Jordi

doi:10.2147/opth.s8637

Cited by 10 publications

(4 citation statements)

References 10 publications

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Section: Discussionmentioning

confidence: 99%

“…The precise extension of PCV was localized at the edge of staphyloma that represents an area of minor retinal resistance and therefore more subject to insult that can determine possible focal alteration and interruption of the RPE-Bruch membrane complex resulting in appearace of CNV. 3,4 Previous studies explained the onset of CNV in MGS due to the hemodynamic and mechanical changes at border of the shaphyloma, as occurs in tilted disc syndrome, where choroidal abnormalities may have induced blood-flow disturbances with consequent hypoxia followed by neovascularization. 5 In this case, OCTA allowed an early diagnosis and, therefore, to start an appropriate therapy, reaching a retinal structural recovery in short time.…”

Section: Declaration Of Conflicting Interestsmentioning

confidence: 99%

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Multimodal imaging in differential diagnosis between papilledema and choroidal neovascularization associated with morning glory syndrome

Cennamo

Montorio

Morra

et al. 2022

European Journal of Ophthalmology

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Purpose To describe the role of optical coherence tomography angiography (OCTA) to help in differential diagnosis between papilledema and a rare case of choroidal neovascularization (CNV) associated with Morning Glory Syndrome (MGS). Methods Observational case report. Results A 22-year old man was referred to Eye clinic from Neurological unit with a diagnosis of papilledema in right eye. OCTA scans on the optic disc revealed a dense radial peripapillary vascular network while two polypoidal choroidal vasculopathy (PCV) were present in peripapillary region at the edge of staphyloma in corrispondence of choriocapillary layer. Therefore, the patient underwent three-monthly intravitreal injections of anti-vascular endothelial growth factor. One and six months after loading phase, the PCVs showed no clinical activity at structural spectral domain-OCT and OCTA. Conclusion This case revealed the crucial role of OCTA as an efficace diagnostic technique in discriminating papilledema from MGS complicated by CNV, allowing to make differential diagnosis, useful in ophthalmological and neurological clinical practice.

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Section: Discussionmentioning

confidence: 99%

Section: Declaration Of Conflicting Interestsmentioning

confidence: 99%

Multimodal imaging in differential diagnosis between papilledema and choroidal neovascularization associated with morning glory syndrome

Cennamo

Montorio

Morra

et al. 2022

European Journal of Ophthalmology

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“…[ 2 6 8 15 16 ] The response of macular conditions to treatment also tends to be varied in TDS. [ 16 17 18 19 ]…”

Section: Discussionmentioning

confidence: 99%

Macular associations of tilted disc syndrome

Kumar

Surve

Kumawat

et al. 2021

Indian Journal of Ophthalmology

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Purpose: The aim of this study was to describe macular changes associated with tilted disc syndrome (TDS) using multimodality imaging. Methods: This is a retrospective observational study of the consecutive TDS cases which were studied for macular changes using color fundus photographs and optical coherence tomography (OCT). Fundus autofluorescence, fundus fluorescein angiography, and OCT angiography were performed wherever required. Results: Twenty consecutive TDS cases (36 eyes) were included. OCT showed inferior depression of all layers in specific scans and macular pathologies seen included lamellar macular hole, full-thickness macular hole, retinal pigment epithelial detachment, acute and resolved subretinal fluid, central serous chorioretinopathy, and choroidal neovascular membrane. Macular involvement was seen in 13 eyes (36.11%) while in the remaining 23 eyes, outer retinal changes were seen on OCT in 9 eyes and normal retinal layers in 14 eyes (38.89%). Conclusion: Various macular pathologies associated with TDS are described using multimodality imaging. These provide understanding of changes which can occur with TDS. It also highlights the need for recognition, differentiation from similar confusing entities, and the necessity to follow-up of these cases carefully to detect the macular changes earlier.

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“…In the quadrant of the TDS margin where the conus is present, there is localized posterior staphyloma, usually on the inferior or inferotemporal side. In cases where the margin of interior posterior staphyloma (IPS) splits the macular region, macular complications such as serous retinal detachment (SRD) [ 3 – 9 ], choroidal neovascularization (CNV) [ 10 – 13 ], retinoschisis (RS) [ 14 ], and retinal pigment epithelium atrophy [ 15 ] often occur. IPS is a feature that is common to both high myopia and TDS.…”

Section: Introductionmentioning

confidence: 99%

Three cases of macular hole that occurred in inferior scleral staphyloma associated with tilted disc syndrome: a case series

et al. 2022

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Background The objective is to examine the clinical characteristics of three patients with macular hole that occurred in inferior posterior staphyloma associated with tilted disc syndrome. Case presentations This study involved three eyes of three Japanese female patients (mean age 76.0 years, range 73–84 years) with macular hole occurring in inferior posterior staphyloma associated with tilted disc syndrome. One of the three eyes was slightly myopic, while the other two eyes were highly myopic. In all three eyes, the macular hole was found to be located in or near the margin of the inferior posterior staphyloma. In one eye, the extent of retinoschisis was rather broad in the margin of the macular hole, and another eye had a history of treatment for choroidal neovascularization. As surgical treatment, the internal limiting membrane in areas surrounding the macular hole was detached after producing artificial posterior vitreous detachment, and a gas tamponade was performed. It was found during surgery that the extensibility of the retina in the margin of the MH was decreased in the three eyes as compared with a usual macular hole. Although the macular hole was successfully closed in all three cases post surgery, the layer structure of the central retina was poorly repaired in all three cases and choroidal neovascularization remained in one case. In all three cases, corrected visual acuity remained at 0.3–0.5 post surgery. Conclusions Our findings showed poor improvement of visual acuity in all three cases post surgery, even if closure of the macular hole is achieved, thus suggesting that in cases of macular hole associated with tilted disc syndrome and inferior posterior staphyloma, the presence of macular dysfunction existing prior to the onset of macular hole affects visual prognosis.

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Ranibizumab in the treatment of choroidal neovascularization on the border of an inferior staphyloma associated with tilted disc syndrome

Cited by 10 publications

References 10 publications

Multimodal imaging in differential diagnosis between papilledema and choroidal neovascularization associated with morning glory syndrome

Multimodal imaging in differential diagnosis between papilledema and choroidal neovascularization associated with morning glory syndrome

Macular associations of tilted disc syndrome

Three cases of macular hole that occurred in inferior scleral staphyloma associated with tilted disc syndrome: a case series

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