Ranges of normal organ weights of dogs

Jackson, Brian P.; Cappiello, Vincent P.

doi:10.1016/0041-008x(64)90116-4

Cited by 16 publications

(2 citation statements)

References 4 publications

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“…The thyroid gland weights whether actual or a percentage of the body weight were in the lower ranges of normality in nearly every instance. Normal ranges are 0.5g-1.6g in the male beagle and 0.4g-1.3g in the female beagle (Jackson and Cappiello, 1964). The biochemical and haematological findings had no diagnostic significance and at autopsy no gross thyroid changes were seen.…”

Section: Resultsmentioning

confidence: 99%

Lymphocytic Thyroiditis in the Dog

Mawdesley-Thomas

1968

J of Small Animal Practice

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Abstract— —A 0.4 per cent incidence of lymphocytic thyroiditis was seen in 4,500 dogs examined. The haematological and biochemical investigations failed to reveal any results of diagnostic significance. The histological features were reminiscent of a human Hashimoto's disease. Whilst the condition was similar to that seen in man, several significant differences were noted. A genetically linked auto‐immune aetiology was considered the most likely. Résumé— —La morbidité de la thyroïdite lymphocytaire constatée au cours de l'examen de 4.500 chiens atteignait 0,4 pour cent. Les examens hématologiques et biochimiques n'ont donné aucun résultat d'intérêt diagnostique. Les caractéristiques histologiques constatées évoquaient la maladie de Hashimoto chez I'homme. L'état des chiens étudiés ressemblait en principe à la maladie rencontrée chez I'homme, mais plusieurs différences ont été nottés. Il y a lieu de croire à une auto‐immunitéà corrélation génétique. Zusammenfassung— —Bei 4500 untersuchten Hunden wurde lymphocytische Thyreoiditis mit einer Häufigkeit von 0,4% beobachtet. Die hämatologischen und biochemischen Untersuchungen lieferten keine Ergebnisse von diagnostischer Bedeutung. Die histologischen Besonderheiten erinner‐ten an die Hashimotosche Krankheit des Menschen. Obwohl der Zustand dem beim Menschen auftretenden glich, wurden doch mehrere Unterschiede bemerkt. Eine genetisch bedingte autoimmune Ätiologie wurde für am wahrscheinlichsten gehalten.

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Section: Resultsmentioning

confidence: 99%

Lymphocytic Thyroiditis in the Dog

Mawdesley-Thomas

1968

J of Small Animal Practice

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“…The allometric equations describing organ weights in the present study were robust, with data (288 kidney weights and 238 heart weights) ranging over more than two orders of magnitude in body weights, from 0.34 to 72 kg. In previously published reports, the data were either collected from a homogenous population or sample sizes were small (Jackson & Cappiello, ; Deavers et al ., ; Steward et al ., ; Lutzen et al ., ; Nemec & Vortel, ; Korhonen & Harri, ). This paucity of data has led veterinary pathologists to estimate normal kidney and heart size as a fixed proportion of body weight.…”

Section: Discussionmentioning

confidence: 99%

Anatomical and physiological basis for the allometric scaling of cisplatin clearance in dogs

Achanta

Sewell

Ritchey

et al. 2015

Vet Pharm & Therapeutics

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Cisplatin is a platinum-containing cytotoxic drug indicated for the treatment of solid tumors in veterinary and human patients. Several of the algorithms used to standardize the doses of cytotoxic drugs utilize allometry, or the nonproportional relationships between anatomical and physiological variables, but the underlying basis for these relationships is poorly understood. The objective of this proof of concept study was to determine whether allometric equations explain the relationships between body weight, kidney weight, renal physiology, and clearance of a model, renally cleared anticancer agent in dogs. Postmortem body, kidney, and heart weights were collected from 364 dogs (127 juveniles and 237 adults, including 51 dogs ≥ 8 years of age). Renal physiological and cisplatin pharmacokinetic studies were conducted in ten intact male dogs including two juvenile and eight adult dogs (4-55 kg). Glomerular filtration rate (GFR), effective renal plasma flow, effective renal blood flow, renal cisplatin clearance, and total cisplatin clearance were allometrically related to body weight with powers of 0.75, 0.59, 0.61, 0.71, and 0.70, respectively. The similar values of these diverse mass exponents suggest a common underlying basis for the allometry of kidney size, renal physiology, and renal drug handling.

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Appendix 1: Normal Organ Weights (Percentage Body Weight)

2016

Necropsy Guide for Dogs, Cats, and Small Mammals

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Ranges of normal organ weights of dogs

Cited by 16 publications

References 4 publications

Lymphocytic Thyroiditis in the Dog

Lymphocytic Thyroiditis in the Dog

Anatomical and physiological basis for the allometric scaling of cisplatin clearance in dogs

Appendix 1: Normal Organ Weights (Percentage Body Weight)

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