Transient deformation events observed in Global Positioning System (GPS) data from the Basin and Range extensional province may illuminate qualitatively similar transient events observed in subduction zones and other tectonic environments. We model GPS time series at 22 sites using a combination of hyperbolic tangent function analysis and elastic load deformation estimated from climatological data. We identify two transient events,~2000.4 and~2004.4, with roughly similar timing and displacement to those described previously by other researchers. The first few years of GPS observations, adopted as a reference state in earlier studies, are found to be anomalous. Our results differ from previous studies in two respects. First, a significant component of northward transient motion occurs during both events, despite a reversal of sign in east component motion. Second, sites move coherently in the eastern as well as the western Basin and Range. Surface mass loading, the largest source of transient stress forcing in the region, exhibits no evidence of a simple relationship to the deformation transients. Prior studies inferred slip on a single megadetachment at the Moho, but that hypothesis assumes negligible ductile deformation of the lower crust and a dry olivine rheology for the uppermost mantle. Recent measurements of crustal quartz abundance and effective elastic thickness suggest both assumptions are unlikely. Basin and Range transients can be reconciled with the frictional slip mechanism widely accepted for subduction zone transients provided that slip is occurring on discontiguous detachment surfaces at midcrustal depths.