Randomized web‐based physical activity intervention in adolescent survivors of childhood cancer

Howell, Carrie R.; Krull, Kevin R.; Partin, Robyn E.; Kadan‐Lottick, Nina S.; Robison, Leslie L.; Hudson, Melissa M.; Ness, Kirsten K.

doi:10.1002/pbc.27216

Cited by 57 publications

(127 citation statements)

References 28 publications

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“…Supervised interventions containing a physical activityeducational and/or exercise intervention in a group setting improved physical activity, quality of life, cardiovascular, physical and metabolic outcomes of cardiovascular diseases [57,58]. Interventions focusing on physical activity or healthy diet of young cancer survivors are practical, feasible and generally well accepted by the participants [54,55,90].…”

Section: Discussionmentioning

confidence: 99%

Comprehensive assessments and related interventions to enhance the long-term outcomes of child, adolescent and young adult cancer survivors – presentation of the CARE for CAYA-Program study protocol and associated literature review

et al. 2020

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Background: Improved, multimodal treatment strategies have been shown to increase cure rates in cancer patients. Those who survive cancer as a child, adolescent or young adult (CAYA), are at a higher risk for therapy-, or diseaserelated, late or long-term effects. The CARE for CAYA-Program has been developed to comprehensively assess any potential future problems, to offer need-based preventative interventions and thus to improve long-term outcomes in this particularly vulnerable population.

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Section: Discussionmentioning

confidence: 99%

Comprehensive assessments and related interventions to enhance the long-term outcomes of child, adolescent and young adult cancer survivors – presentation of the CARE for CAYA-Program study protocol and associated literature review

et al. 2020

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“…88,89 Alternatively, several small RCTs have evaluated home-based mobile health interventions, but reported no significant differences in physical activity levels after 10-24 weeks, suggesting that structured exercise and/or supervised exercise may be required to improve cardiovascular endpoints. 90,91 An RCT evaluating the efficacy of a 12-month home-based aerobic and resistance exercise on cardiovascular risk factors among 150 childhood cancer survivors is ongoing. 92…”

Section: Exercise Interventionsmentioning

confidence: 99%

Paediatric cardio-oncology: epidemiology, screening, prevention, and treatment

Chow

Leger

Bhatt

et al. 2019

Cardiovascular Research

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With 5-year survival of children with cancer exceeding 80% in developed countries, premature cardiovascular disease is now a major cause of early morbidity and mortality. In addition to the acute and chronic cardiotoxic effects of anthracyclines, related chemotherapeutics, and radiation, a growing number of new molecular targeted agents may also have detrimental effects on the cardiovascular system. Survivors of childhood cancer also may have earlier development of conventional cardiovascular risk factors such as hypertension, dyslipidaemia, and diabetes, which further increase their risk of serious cardiovascular disease. This review will examine the epidemiology of acute and chronic cardiotoxicity relevant to paediatric cancer patients, including genetic risk factors. We will also provide an overview of current screening recommendations, including the evidence regarding both imaging (e.g. echocardiography and magnetic resonance imaging) and blood-based biomarkers. Various primary and secondary prevention strategies will also be discussed, primarily in relation to anthracycline-related cardiomyopathy. Finally, we review the available evidence related to the management of systolic and diastolic dysfunction in paediatric cancer patients and childhood cancer survivors.

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“…29 Studies incorporating a FitBit or other electronic activity monitor found trackers to be acceptable to AYAs. 26,27,30 Taken together, these studies suggest that an in-person supervised intervention may have good initial impact but could be enhanced by incorporating mobile interventions that are acceptable to AYA and more likely to be integrated into daily life. No studies to date have combined the in-person group-based approach enhanced with mobile technology to capitalize on the strengths of each approach.…”

Section: Introductionmentioning

confidence: 87%

“…[23][24][25] Few studies specifically target AYA survivors of pediatric cancers. [26][27][28][29][30][31] Of those studies targeting AYA survivors of pediatric cancer, almost all found positive but not statistically significant improvements in physical activity and fitness outcomes, which may be attributed to small sample size. Of note, a group-based community intervention found significant improvements in physical activity and fitness outcomes postintervention, but gains were not maintained at follow up.…”

Section: Introductionmentioning

confidence: 99%

Feasibility of FitSurvivor: A technology‐enhanced group‐based fitness intervention for adolescent and young adult survivors of childhood cancer

Devine

Viola

Levonyan‐Radloff

et al. 2020

Pediatric Blood & Cancer

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Background This study evaluated the feasibility of a technology‐enhanced group‐based fitness intervention for adolescent and young adult (AYA) survivors of childhood cancer. Procedure AYA survivors ages 13‐25 years were randomized to the intervention (eight in‐person group sessions with mobile app and FitBit followed by 4 weeks of app and FitBit only) or waitlist control. Assessments were at 0, 2, 3, 6, and 9 months. Feasibility was evaluated by enrollment, retention, attendance, app engagement, and satisfaction. Secondary outcomes included physical activity, muscular strength/endurance, cardiorespiratory fitness, health‐related quality of life, and fatigue. Results A total of 354 survivors were mailed participation letters; 68 (19%) were screened, of which 56 were eligible and 49 enrolled (88% of those screened eligible, 14% of total potentially eligible). Forty‐nine survivors (Mage = 18.5 years, 49% female) completed baseline assessments and were randomized (25 intervention, 24 waitlist). Thirty‐seven (76%) completed the postintervention assessment and 32 (65%) completed the final assessment. On average, participants attended 5.7 of eight sessions (range 1‐8). Overall intervention satisfaction was high (M = 4.3, SD = 0.58 on 1‐5 scale). Satisfaction with the companion app was moderately high (M = 3.4, SD = 0.97). The intervention group demonstrated significantly greater improvement in lower body muscle strength compared to the waitlist postintervention, and small but not statistically significant changes in other secondary measures. Conclusions A group‐based intervention with a mobile app and fitness tracker was acceptable but has limited reach due to geographical barriers and competing demands experienced by AYA survivors.

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Randomized web‐based physical activity intervention in adolescent survivors of childhood cancer

Abstract: An interactive, rewards-based intervention designed to increase MVPA is feasible in adolescent survivors of childhood cancer.

Cited by 57 publications

References 28 publications

Comprehensive assessments and related interventions to enhance the long-term outcomes of child, adolescent and young adult cancer survivors – presentation of the CARE for CAYA-Program study protocol and associated literature review

Comprehensive assessments and related interventions to enhance the long-term outcomes of child, adolescent and young adult cancer survivors – presentation of the CARE for CAYA-Program study protocol and associated literature review

Paediatric cardio-oncology: epidemiology, screening, prevention, and treatment

Feasibility of FitSurvivor: A technology‐enhanced group‐based fitness intervention for adolescent and young adult survivors of childhood cancer

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