Randomized trials published in some Chinese journals: how many are randomized?

Wu, Taixiang; Li, Youping; Bian, Zhaoxiang; Liu, Guanjian; Moher, David

doi:10.1186/1745-6215-10-46

Cited by 198 publications

(152 citation statements)

References 14 publications

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“…Предыдущий ана-лиз, выполненный A. Vickers и соавт., а также T. Wu и соавт., показал, что результаты большинства иссле-дований, проведенных в Китае, были зарегистриро-ваны как положительные. Тем не менее большинст-во докладов о рандомизированных контролируемых испытаниях, опубликованных в некоторых китайских журналах, не имели адекватного описания процедуры рандомизации [71,72], что подтверждает полученные нами выводы [8]. Хотя существуют несколько объясне-ний этого явления, наиболее вероятным обоснованием является медленное внедрение методов доказательной медицины и методологии клинических испытаний в научно-исследовательские центры [73].…”

Section: статистический анализunclassified

Acupuncture in Poststroke Rehabilitation

Mills²,

Moher³

et al. 2010

Stroke

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162

108

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Background and Purpose-Acupuncture is a low-risk treatment with purported claims of effectiveness for poststroke rehabilitation. To comprehensively assess the efficacy of acupuncture in poststroke rehabilitation, we conducted a systematic review and meta-analysis of all randomized clinical trials of acupuncture for poststroke rehabilitation. Methods-We searched 7 English and 2 Chinese databases from inception to September 2009. Eligible studies included randomized clinical trials that evaluated the clinical efficacy of acupuncture in adult patients with disability after stroke. We extracted data on trial quality, protocol, and outcomes assessed. A summary OR was calculated based on pooled dichotomous results. I 2 was used to infer heterogeneity and we conducted metaregression to determine if specific covariates explained heterogeneity. Results-Thirty-five articles written in Chinese and 21 articles written in English were included. The overall quality of the studies was "fair" and most studies were small (median nϭ86; range, 16 to 241). The majority (80%) of the studies reported a significant benefit from acupuncture; however, there was some evidence of publication bias. In 38 trials, data were available for meta-analysis and metaregression, yielding an OR in favor of acupuncture compared with controls (ORϭ4.33, 95% CI: 3.09 to 6.08; I 2 ϭ72.4%). Randomization, modes of delivery, method of control, study source country, and reporting of randomization may explain some of the heterogeneity observed between the studies. Conclusions-Randomized clinical trials demonstrate that acupuncture may be effective in the treatment of poststroke rehabilitation. Poor study quality and the possibility of publication bias hinder the strength of this recommendation and argue for a large, transparent, well-conducted randomized clinical trial to support this claim and implement changes to clinical practice. (Stroke. 2010;41:e171-e179.)Key Words: acupuncture Ⅲ cerebral infarct Ⅲ cerebrovascular disease Ⅲ meta-analysis Ⅲ metaregression Ⅲ systematic review Ⅲ therapy S troke is responsible for increasingly high rates of mortality and disability worldwide. Due to an aging population, dietary changes, and work-related stress, stroke morbidity is on the rise and the age at first occurrence is getting younger. [1][2][3] According to the latest data issued by the American Heart Association, each year approximately 600 000 people experience a new stroke and 185 000 a recurrent stroke. 3 Besides resultant mortality, the high incidence (Ͼ50%) of poststroke disability brings a heavy burden to patients and their caregivers. 3 In the United States, the total societal and healthcare costs have risen from $53.6 billion in 2004 2 to $68.9 billion in 2009. 3 Acupuncture (Ac) has been used in traditional Chinese medicine for Ͼ3000 years as a treatment for many diseases and its use for poststroke rehabilitation in China is based on a large body of preclinical and clinical research. 4 The lack of English language publications has, however, impeded any ...

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Section: статистический анализunclassified

Acupuncture in Poststroke Rehabilitation

Mills²,

Moher³

et al. 2010

Stroke

Self Cite

162

108

View full text Add to dashboard Cite

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“…Various PubMed searches (searches [1][2][3][4][5][6] were conducted between March and December 2012 for different aspects of the study, as described, together with results, in the web-only supplementary appendix. Resources were insufficient to include other electronic databases to maximise inclusion of non-English papers.…”

Section: Trends In Publication Methodsmentioning

confidence: 99%

An Exploratory Review of the Electroacupuncture Literature: Clinical Applications and Endorphin Mechanisms

Mayor

2013

Acupunct Med

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Electroacupuncture (EA) is widely used in clinical practice and research, as well as in experimental investigations into the mechanisms of acupuncture. This study explores publication trends in clinical and experimental studies of EA (1975EA ( -2011 for pain and non-pain research; EA use for different clinical conditions ; and the relation of EA research, including stimulation frequency, to opioid peptide mechanisms. Appropriate PubMed 'all fields' searches were conducted, identified studies were classified using PubMed filters and manually, and data extracted into tables. A total of 2916 clinical studies were located, of which 19% involved EA. Additionally, 3344 animal studies were located, of which 48% involved EA. The publication rate of EA studies per year has risen over time, but the percentage of studies of pain has fallen from 60% to 25%. The conditions most commonly treated with EA are musculoskeletal, neurological, obstetric and gastrointestinal, along with intraoperative and postoperative analgesia. EA studies, particularly with low frequency stimulation, are more likely to support the role of endogenous opioid mechanisms than manual acupuncture studies, and opioid release is more likely in the central nervous system than the circulation. EA is increasingly used in clinical and especially experimental research, particularly for non-pain conditions. Acupuncture does release endogenous opioids, but this probably depends on 'dosage', with the evidence more consistent and convincing for EA than for manual acupuncture. Different frequencies of EA appear to activate different endogenous opioid mechanisms.

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“…75 Selection bias owing to inadequate randomisation may be one reason for the relatively high proportion of positive results that has been noted in Chinese trials. 129 Those found in the searches for this review were all positive and, although the inadequate reporting of methods has made it impossible to assess their quality, it is plausible that selection bias and bias from unblinded outcome assessment and analysis were contributing factors.…”

Section: Chinese Studies Of Head Coolingmentioning

confidence: 99%

“…129 Trial investigators were interviewed on the telephone and of 2235 studies only 207 (6.8%; 95% CI 5.9% to 7.7%) were found to be authentic RCTs. Most of those interviewed (85.6%) did not fully understand randomisation when they claimed that their trials were randomised.…”

Section: Chinese Studies Of Head Coolingmentioning

confidence: 99%

Systematic review of head cooling in adults after traumatic brain injury and stroke

Harris

Andrews²,

Murray³

et al. 2012

Health Technol Assess

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An electronic version of this title, in Adobe Acrobat format, is available for downloading free of charge for personal use from the HTA website (www.hta.ac.uk). A fully searchable DVD is also available (see below).Printed copies of HTA journal series issues cost £20 each (post and packing free in the UK) to both public and private sector purchasers from our despatch agents.Non-UK purchasers will have to pay a small fee for post and packing. For European countries the cost is £2 per issue and for the rest of the world £3 per issue. How to order:-fax (with credit card details) -post (with credit card details or cheque) -phone during office hours (credit card only).Additionally the HTA website allows you to either print out your order or download a blank order form. Contact details are as follows:Synergie UK (HTA Department) Digital House, The Loddon Centre Wade Road Basingstoke Hants RG24 8QW Email: orders@hta.ac.uk Tel: 0845 812 4000 -ask for 'HTA Payment Services' (out-of-hours answer-phone service) Fax: 0845 812 4001 -put 'HTA Order' on the fax header Payment methods Paying by chequeIf you pay by cheque, the cheque must be in pounds sterling, made payable to University of Southampton and drawn on a bank with a UK address.Paying by credit card You can order using your credit card by phone, fax or post. SubscriptionsNHS libraries can subscribe free of charge. Public libraries can subscribe at a reduced cost of £100 for each volume (normally comprising 40-50 titles). The commercial subscription rate is £400 per volume (addresses within the UK) and £600 per volume (addresses outside the UK). Please see our website for details. Subscriptions can be purchased only for the current or forthcoming volume.How do I get a copy of HTA on DVD?Please use the form on the HTA website (www.hta.ac.uk/htacd/index.shtml). HTA on DVD is currently free of charge worldwide.The website also provides information about the HTA programme and lists the membership of the various committees. HTA NIHR Health Technology Assessment programmeThe Health Technology Assessment (HTA) programme, part of the National Institute for Health Research (NIHR), was set up in 1993. It produces high-quality research information on the effectiveness, costs and broader impact of health technologies for those who use, manage and provide care in the NHS. 'Health technologies' are broadly defined as all interventions used to promote health, prevent and treat disease, and improve rehabilitation and long-term care. The research findings from the HTA programme directly influence decision-making bodies such as the National Institute for Health and Clinical Excellence (NICE) and the National Screening Committee (NSC). HTA findings also help to improve the quality of clinical practice in the NHS indirectly in that they form a key component of the 'National Knowledge Service' . The HTA programme is needs led in that it fills gaps in the evidence needed by the NHS. There are three routes to the start of projects. First is the commissioned route. Suggestions for research...

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Randomized trials published in some Chinese journals: how many are randomized?

Cited by 198 publications

References 14 publications

Acupuncture in Poststroke Rehabilitation

Acupuncture in Poststroke Rehabilitation

An Exploratory Review of the Electroacupuncture Literature: Clinical Applications and Endorphin Mechanisms

Systematic review of head cooling in adults after traumatic brain injury and stroke

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