Randomized trials of multicancer screening tests: augmenting their ability to identify a genuine mortality benefit
Noel S Weiss
Abstract:Randomized trials of the efficacy of multi-cancer early detection, by means of measurement of cell-free DNA and/or protein biomarkers in peripheral blood specimens, will attempt to document a difference in cancer mortality between persons assigned to intervention and control arms. Their ability to do so is limited by the relatively low rate of death from individual forms of cancer, the relatively low sensitivity of the tests currently being used, and the use of other cancer screening modalities among trial par… Show more
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