Randomized Trial to Evaluate the Efficacy of Cognitive Therapy for Low-Functioning Patients With Schizophrenia

Grant, Paul M.; Huh, Gloria A.; Perivoliotis, Dimitri; Stolar, Neal; Beck, Aaron T.

doi:10.1001/archgenpsychiatry.2011.129

Cited by 312 publications

(249 citation statements)

References 41 publications

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“…There is some evidence suggesting that cognitive behavioral therapy focused on negative symptoms is effective in schizophrenic patients without 22q11.2DS (Klingberg et al, 2011;Perivoliotis & Cather, 2009). Interestingly, a recently published article showed that this type of intervention improved motivation in low-functioning patients with schizophrenia (Grant et al, 2012). This may indicate that similar strategies could be implemented in patients with 22q11.2DS to improve negative symptoms.…”

Section: A C C E P T E D Accepted Manuscriptmentioning

confidence: 96%

Predominant negative symptoms in 22q11.2 deletion syndrome and their associations with cognitive functioning and functional outcome

Schneider

Linden

Menghetti

et al. 2014

Journal of Psychiatric Research

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Abstract22q11.2 deletion syndrome (22q11.2DS) is a neurogenetic condition associated with increased risk for schizophrenia. No study do date has explored how positive and negative symptoms of psychosis are distributed among individual patients with 22q11.2DS and if distinct patterns of symptoms can be identified. Negative symptoms being more frequent than positive symptoms in 22q11.2DS, we expected that a high number of patients would display predominant negative symptoms (PNS), whereas predominant positive symptoms would be less frequently experienced.The present study aims at investigating the cognitive deficits and functional outcome associated with distinct patterns of psychotic symptoms in 22q11.2DS. 63 adolescents and young adults with 22q11.2DS participated in this study. Each participant underwent a clinical and a cognitive evaluation. A cluster analysis was used to identify groups of individuals with distinct patterns of symptoms. Individuals from the different clusters were then compared on a series of cognitive measures and on functional outcome. Three clusters of individuals were identified: low levels of symptoms, PNS, and high levels of symptoms. Individuals with PNS had significantly lower visual memory scores and decreased processing speed compared to participants with low levels of symptoms. They were also rated as having lower functional and occupational outcome. The present results indicate that one third of adolescents and young adults with 22q11.2DS display PNS. This pattern of symptoms was associated with specific cognitive deficits and decreased functional outcome. Future studies are needed to examine the developmental trajectories of these individuals and assess their risk of conversion to full-blown psychosis.

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Section: A C C E P T E D Accepted Manuscriptmentioning

confidence: 96%

Predominant negative symptoms in 22q11.2 deletion syndrome and their associations with cognitive functioning and functional outcome

Schneider

Linden

Menghetti

et al. 2014

Journal of Psychiatric Research

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“…Although recent psychosocial treatments have shown efficacy in improving a subset of negative symptoms (Grant et al, 2012;Granholm et al, 2014;Grant et al, 2014), negative symptoms can often persist despite psychosocial treatments and antipsychotic medication (Tandon et al, 2010). …”

Section: Introductionmentioning

confidence: 99%

Expectancies of success as a predictor of negative symptoms reduction over 18 months in individuals with schizophrenia

Luther

Fukui

Firmin

et al. 2015

Psychiatry Research

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(2015). Expectancies of success as a predictor of negative symptoms reduction over 18 months in individuals with schizophrenia. Psychiatry Research, 229(1-2), 505-510. http://doi.org/10.1016/j.psychres.2015.06.022Running head: EXPECTANCIES OF SUCCESS AND NEGATIVE SYMPTOMS  We examine expectancies of success-beliefs of future success and goal attainment.  118 individuals with schizophrenia-spectrum disorders completed an 18 month study.  High and moderate expectancies of success predicted reduced negative symptoms.  Findings support the cognitive model of negative symptoms. *HighlightsRunning head: EXPECTANCIES OF SUCCESS AND NEGATIVE SYMPTOMS EXPECTANCIES OF SUCCESS AND NEGATIVE SYMPTOMS 2 AbstractNegative symptoms are often enduring and lead to poor functional outcomes in individuals with schizophrenia. The cognitive model of negative symptoms proposes that low expectancies of success contribute to the development and maintenance of negative symptoms; however, longitudinal investigations assessing these beliefs and negative symptoms are needed. The current study examined whether an individual's baseline expectancies of success--one's beliefs about future success and goal attainment--predicted negative symptom reduction over 18 months in individuals with schizophrenia-spectrum disorders (n = 118). Data were collected at baseline, 9 months, and 18 months as part of a randomized controlled trial of Illness Management and Recovery. A mixed effects regression analysis revealed a significant reduction in negative symptoms over time, with a significant interaction effect between time and baseline expectancies of success. After controlling for baseline negative symptoms, demographic variables, and treatment conditions, those with high and moderate baseline expectancies of success evidenced a significant reduction in negative symptoms at 18 months, while those with low baseline expectancies of success did not evidence reduced negative symptoms. Findings support the cognitive model of negative symptoms and suggest that expectancies of success may be a useful treatment target for interventions aimed at reducing negative symptoms.

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“…Collaborative development of imagery scripts with clients focusing on personal recovery goals could usefully augment existing thought-challenging approaches (Grant et al, 2012), subject to further controlled evaluation, faciliating engagement in meaningful and valued activity for this neglected group, and improving their quality of life. …”

Section: Resultsmentioning

confidence: 99%

“…Role playing future events (e.g. Grant et al, 2012); broadening present positive affect to apply to a vision of the future (e.g. Johnson et al, 2012); and guided positive imagery of a future activity (e.g.…”

Section: Psychological Models Of Negative Symptoms In Psychosismentioning

confidence: 99%

Understanding and treating amotivation in people with psychosis: An experimental study of the role of guided imagery

Cox

Jolley

Johns

2016

Psychiatry Research

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Randomized Trial to Evaluate the Efficacy of Cognitive Therapy for Low-Functioning Patients With Schizophrenia

Abstract: Cognitive therapy can be successful in promoting clinically meaningful improvements in functional outcome, motivation, and positive symptoms in low-functioning patients with significant cognitive impairment. Trial Registration clinicaltrials.gov Identifier: NCT00350883.

Cited by 312 publications

References 41 publications

Predominant negative symptoms in 22q11.2 deletion syndrome and their associations with cognitive functioning and functional outcome

Predominant negative symptoms in 22q11.2 deletion syndrome and their associations with cognitive functioning and functional outcome

Expectancies of success as a predictor of negative symptoms reduction over 18 months in individuals with schizophrenia

Understanding and treating amotivation in people with psychosis: An experimental study of the role of guided imagery

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