Randomized trial of two beta-mimetic drugs (ritodrine and fenoterol) in acute intra-partum tocolysis

Abstract

The uterine inhibitory effect and potential maternal and fetal side effects of two beta-mimetic compounds, ritodrine hydrochloride and fenoterol hydrobromide, were compared in a randomized trial. The drugs were administered by intravenous infusion to 24 healthy term nulliparous women during effective first-stage labour; each of them received fenoterol (1, 2, or 4 microgram/min) or ritodrine (100, 200, or 400 microgram/min). There was no difference between the drugs in the intensity of the uterine inhibition. However, for a similar inhibitory effect, the duration of tocolysis was longer after ritodrine. During the intrapartum and neonatal periods, neither compound induced any change in the fetal parameters investigated, and their effects on maternal parameters were comparable.

Different effects of tocolytic medication on blood pressure and blood pressure amplification

“…Glucose 5% was given as placebo at a constant infusion rate of 0.4ml/min. Dosing was based on previous studies using atosiban or ritodrine [3,[17][18][19][20] and on the manufacturers prescriptions. Each period, a total volume of 48ml was infused.…”

Severe Cardiotocographic Pathology at Labor: Effect of Acute Intravenous Tocolysis

“…b-mimetic drugs (ritodrine, terbutaline, fenoterol, buphenine, and hexoprenaline), nitroglycerin, and magnesium sulfate have been used as tocolytic agents during delivery. [15][16][17][18][19][20] Magann et al 21 showed in 1993 the superiority of terbutaline over magnesium sulfate in acute tocolysis. To date, there have been no comparative studies between b-mimetics and nitroglycerin in acute tocolysis.…”

Cost-Effectiveness of Ritodrine and Fenoterol for Treatment of Preterm Labor in a Low–Middle-Income Country: A Case Study

“…The b-mimetic agents, ritodrine and fenoterol, administered via intravenous infusion, have proven efficacy for short-term tocolysis. Either tocolytic can be used as first-line tocolysis in patients without serious cardiovascular disease [1][2][3]. Nevertheless, there are conflicting results concerning the effectiveness of oral b-mimetic agents in the maintenance treatment of preterm labor.…”