There were no major differences in outcome in this trial including 276 procedures. Patients who had surgery under local anaesthetic had less pain after six hours, but were less likely to recommend the operation to someone else. The trial was terminated after 508 patients had been randomized and followed for a mean of 2·1 years. Compared with placebo, low intensity warfarin (INR 1·5 to 2) given after standard six month anticoagulation reduced the risk of recurrent thrombosis by 64 per cent (hazard ratio 0·36, 95 per cent confidence interval 0·19 to 0·67, P < 0·001).Peng BC, Jayne DG, Ho Y-H. Randomized trial of rubber band ligation versus stapled hemorrhoidectomy for prolapsed piles. Dis Colon Rectum 2003; 46: 291-297.Stapled haemorrhoidectomy was associated with more pain at both two week and two month follow-up in this study of 55 patients. Both procedures controlled prolapse, but recurrent bleeding was more common after banding (P = 0·002). In this study that included 635 patients, 325 mg aspirin daily for a minimum of one year reduced the risk of finding further polyps on colonoscopy from 27 to 17 per cent, P = 0·004. Fifty-six patients were randomly allocated to lansoprazole for 12 weeks after pylorus-preserving surgery or a control group. Serum gastrin was increased in the treatment group and this appeared to reduce the amount of pancreatic atrophy and preserve insulin levels.