2015
DOI: 10.1056/nejmsa1502403
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Randomized Trial of Reduced-Nicotine Standards for Cigarettes

Abstract: BACKGROUND The Food and Drug Administration can set standards that reduce the nicotine content of cigarettes. METHODS We conducted a double-blind, parallel, randomized clinical trial between June 2013 and July 2014 at 10 sites. Eligibility criteria included an age of 18 years or older, smoking of five or more cigarettes per day, and no current interest in quitting smoking. Participants were randomly assigned to smoke for 6 weeks either their usual brand of cigarettes or one of six types of investigational ci… Show more

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Cited by 343 publications
(587 citation statements)
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References 27 publications
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“…Smoking cigarettes that deliver less than conventional doses of nicotine (ie,~1 mg/cigarette) reduce nicotine dependence (Benowitz et al, 2007;Benowitz et al, 2012;Benowitz et al, 2015) and promote smoking cessation when used with transdermal nicotine (Hatsukami et al, 2013). Further, a trial of reduced-nicotine cigarettes delivering~0.05-1.2 mg nicotine in 780 smokers showed decreases in nicotine dependence and cigarette consumption at 6 weeks compared to baseline (Donny et al, 2015).…”
Section: Introductionmentioning
confidence: 99%
“…Smoking cigarettes that deliver less than conventional doses of nicotine (ie,~1 mg/cigarette) reduce nicotine dependence (Benowitz et al, 2007;Benowitz et al, 2012;Benowitz et al, 2015) and promote smoking cessation when used with transdermal nicotine (Hatsukami et al, 2013). Further, a trial of reduced-nicotine cigarettes delivering~0.05-1.2 mg nicotine in 780 smokers showed decreases in nicotine dependence and cigarette consumption at 6 weeks compared to baseline (Donny et al, 2015).…”
Section: Introductionmentioning
confidence: 99%
“…Nardone et al [1] extend a previous publication [2] by reporting that lower 'satisfaction' from very low nicotine cigarettes (VLNC) predicts non-compliance with VLNC. While only 39% of participants reported non-compliance, a new objective measure indicates that 78% were probably smoking other cigarettes.…”
mentioning
confidence: 82%
“…Mixing more satisfying nicotine products with fully toxic, less satisfying low nicotine cigarettes will probably influence net satisfaction, longevity of their use and health effects.Nardone et al[1] extend a previous publication [2] by reporting that lower 'satisfaction' from very low nicotine cigarettes (VLNC) predicts non-compliance with VLNC. While only 39% of participants reported non-compliance, a new objective measure indicates that 78% were probably smoking other cigarettes.…”
mentioning
confidence: 99%
“…[2,3]). The strategy proposes that, for the good of public health, the only cigarettes that should be sold legally must contain such low levels of nicotine in the tobacco that they would not create or support addiction.…”
Section: The Seemingly Inexorable Momentum Toward Mandatory Very-low-mentioning
confidence: 99%
“…The FDA has become the major funder of tobacco research in the United States, devoting tens of millions of dollars to pursuing the strategy. What has been viewed as the best study to date was published recently to much acclaim [2]. The World Health Organization's (WHO) TogReg committee has advised that such a strategy should eventually become an element of tobacco control [5].…”
Section: The Seemingly Inexorable Momentum Toward Mandatory Very-low-mentioning
confidence: 99%