Randomized trial of pimecrolimus cream versus triamcinolone acetonide paste in the treatment of oral lichen planus

Gorouhi, Farzam; Solhpour, Ali; Beitollahi, Jalil Momen; Afshar, Shahla; Davari, Parastoo; Hashemi, Payam; Nassiri-Kashani, Mansour; Firooz, Alireza

doi:10.1016/j.jaad.2007.06.022

Cited by 92 publications

(97 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…For this reason, a clinical follow-up of patients with OLP, including repeated biopsies of recurrent or recalcitrant lesions is recommendable for any treatment (12,15). Different topical and systemic drug have been used in the treatment of this disorder with various results, occasionally with significant side effects (13,16). Well-known side effects related to longtime topical corticosteroid use to oral cavity include dermal atrophy, contact sensitivity, and fungal infections (13,16,17).…”

Section: Discussionmentioning

confidence: 99%

“…Different topical and systemic drug have been used in the treatment of this disorder with various results, occasionally with significant side effects (13,16). Well-known side effects related to longtime topical corticosteroid use to oral cavity include dermal atrophy, contact sensitivity, and fungal infections (13,16,17). Because of the chronic course of OLP and the potential side effects mentioned above related to potent topical steroids, there is a need for choice well tolerated treatments, which is why we investigated the efficacy and safety of topical pimecrolimus in OLP.…”

Section: Discussionmentioning

confidence: 99%

“…It has been tried to be effective in different inflammatory skin diseases, eg, seborrheic dermatitis, psoriasis, vitiligo, and cutaneous lupus erythematosus. In addition, some case reports have shown its safety and successful use in the treatment of children with anogenital lichen sclerosus and children with lichen aureus (8,13,16,18,19).…”

Section: Discussionmentioning

confidence: 99%

“…Gorouhi et al (16) showed that in an investigator-blinded parallel-group randomized clinical trial, 40 patient were randomly assigned in two equal groups to receive either pimecrolimus 1% cream or triamcinolone acetonide 0.1% paste four times daily for a total two months and followed up for another two months. Both pimecrolimus and triamcinolone groups showed significant improvement in all measured efficacy and points throughout the visits.…”

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

The Effectiveness of Topical Pimecrolimus in the Treatment of Oral Lichen Planus

Mülayim¹,

Öztürk²,

Uzun³

2016

tdd

View full text Add to dashboard Cite

Objectives: Oral lichen planus (OLP) is a chronic inflammatory disorder of unknown etiology that affects the skin and the mucosa, especially the oral mucosa. Several therapeutic agents have been investigated for the treatment of OLP. All agents used in the OLP therapy are palliative. Potent topical steroids are used as the conventional therapy for OLP. Since side-effects or steroid resistance may be encountered, alternative treatments may be necessary. This study aimed to evaluate the efficacy and safety of the topical pimecrolimus in the treatment of OLP. Methods: Seventeen patients with OLP were recruited into this study. Topical pimecrolimus 1% cream was applied twice a day to the affected areas. Patients were followed up for 3-6 months. Photographs of the lesions were taken and analyzed for areas of ulceration, erythema, and reticulation in every clinical examination. Results: We found that topical pimecrolimus 1% cream was an effective treatment for OLP. Two patients could not complete the treatment protocol because of the side effects such as local irritation and nausea. Conclusion: Topical pimecrolimus may be a valuable second treatment choice for patients with steroid-related side-effects or steroid-resistant OLP. However further randomized controlled studies have to be conducted to compare conventional treatment of topical corticosteroid with topical pimecrolimus. Keywords: Oral lichen planus, pimecrolimus, calcineurin inhibitor, treatment, efficacy, safety Öz Abstract Amaç: Oral liken planus (OLP) deri ve mukozaları özellikle de oral mukozayı tutan, etiyolojisi bilinmeyen kronik enflamatuvar bir hastalıktır. OLP tedavisi için birkaç terapötik ajan araştırılmıştır. OLP'nin tedavisinde kullanılan bütün ajanlar palyatif etkilidir. OLP'nin geleneksel tedavisinde potent topikal steroidler kullanılır. Steroidlerin yan etkileri veya steroide direnç ile karşılaşılabileceğinden alternatif tedaviler gerekli olabilir. Bu çalışmada topikal pimekrolimusun OLP'nin tedavisindeki etkinliğini ve güvenirliğini değerlendirmek amaçlandı. Yöntemler: OLP'li 17 hasta çalışmaya alındı. Topikal pimekrolimus %1 krem etkilenmiş bölgelere günde 2 kez uygulandı. Hastalar 3-6 ay süreyle aylık olarak takip edildi. Her kontrolde lezyonların fotoğrafı çekilerek ülserasyon, eritem ve ağ yapısı gibi özellikleri değerlendirildi. Bulgular: Biz OLP'nin tedavisinde topikal %1 pimekrolimusu etkili bulduk. Çalışmaya alınan iki hasta bulantı hissi ve lokal irritasyon gibi yan etkiler nedeni ile tedavi protokolünü tamamlayamadı. Sonuç: Topikal pimekrolimus, steroid ile ilişkili yan etkileri olan hastalarda veya steroide dirençli OLP'nin tedavisinde ikinci seçenek olarak düşünülebilir. Ancak etkinliği tam olarak değerlendirebilmek için OLP'nin geleneksel tedavisi olan topikal steroid ile topikal pimekrolimusun karşılaştırmalı, randomize, kontrollü çalışmaları yapılmalıdır.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

The Effectiveness of Topical Pimecrolimus in the Treatment of Oral Lichen Planus

Mülayim¹,

Öztürk²,

Uzun³

2016

tdd

View full text Add to dashboard Cite

show abstract

“…The ointment must be applied twice daily, but use may be increased to four times daily until remission or symptomatic relief [21][22][23][24][25][26]. There are a few reports about these drugs on labial LP [10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27].…”

Section: Treatmentmentioning

confidence: 99%

Lichen Planus Affecting the Lips

Fern¹,

es²,

Lourenço³

2015

Clin Exp Dermatol Res

View full text Add to dashboard Cite

Lichen planus frequently compromises the skin, and the oral mucosa. There is plenty of medical and dental literature about the cutaneous and mucosal lesions of lichen planus, but, comparatively very little has been written specifically about lichen planus compromising the lip vermilion. This structure has a peculiar anatomical and histological architecture, and lichen planus lesions at this site may have some distinct features. This article reviews the recent literature about labial lichen planus in all of its presentations, highlighting some special clinical features that may enable a better diagnosis and differential diagnosis of lip diseases. Besides, personal experience by the authors is added.

show abstract