Randomized trial of hyperbaric oxygen therapy for children with autism

Granpeesheh, Doreen; Tarbox, Jonathan; Dixon, Dennis R.; Wilke, Arthur E.; Allen, Michael S.; Bradstreet, James Jeffrey

doi:10.1016/j.rasd.2009.09.014

Cited by 45 publications

(59 citation statements)

References 23 publications

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“…HBOT involves the application of gases into a confi ned chamber, ranging from normal levels of oxygen (21 %) to enhanced levels of oxygen (up to 100 %) under differing amounts of pressure (Granpeesheh et al, 2010 ). Exploratory fi ndings have indicated that individuals with ASD have oxidative stress and nueroinfl ammation, both of which have been successfully limited in rat populations using HBOT (Granpeesheh et al, 2010 ). As with the other treatments discussed above, this approach is based on fl awed or unproven theoretical underpinnings, however this has not prevented its wide usage.…”

Section: Hyperbaric Oxygen Therapymentioning

confidence: 99%

“…As with the other treatments discussed above, this approach is based on fl awed or unproven theoretical underpinnings, however this has not prevented its wide usage. To date rigorous scientifi c research (Granpeesheh et al, 2010 ;Jepson et al, 2011 ) has indicated that HBOT does not result in improvements in ASD symptoms. This is another example of a controversial, expensive treatment based on unfounded ideas that is without supporting evidence .…”

Section: Hyperbaric Oxygen Therapymentioning

confidence: 99%

See 1 more Smart Citation

Fad, Pseudoscientific, and Controversial Interventions

Travers

Ayers²,

Simpson

et al. 2016

Evidence-Based Practices in Behavioral Health

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Section: Hyperbaric Oxygen Therapymentioning

confidence: 99%

Section: Hyperbaric Oxygen Therapymentioning

confidence: 99%

Fad, Pseudoscientific, and Controversial Interventions

Travers

Ayers²,

Simpson

et al. 2016

Evidence-Based Practices in Behavioral Health

View full text Add to dashboard Cite

“…In a subsequent study, Granpeesheh et al (2010) conducted a randomized, double-blind, placebo controlled evaluation of HBOT, consisting of 80 1-h sessions at 24% oxygen and 1.3 ATA. Sessions were administered 6-10 times per week.…”

Section: Autism Hbot Studies and Limitationsmentioning

confidence: 99%

Controlled Evaluation of the Effects of Hyperbaric Oxygen Therapy on the Behavior of 16 Children with Autism Spectrum Disorders

Jepson

Granpeesheh

Tarbox

et al. 2010

J Autism Dev Disord

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Hyperbaric oxygen therapy (HBOT) has been used to treat individuals with autism. However, few studies of its effectiveness have been completed. The current study examined the effects of 40 HBOT sessions at 24% oxygen at 1.3 ATA on 11 topographies of directly observed behavior. Five replications of multiple baselines were completed across a total of 16 participants with autism spectrum disorders. No consistent effects were observed across any group or within any individual participant, demonstrating that HBOT was not an effective treatment for the participants in this study. This study represents the first relatively large-scale controlled study evaluating the effects of HBOT at the level of the individual participant, on a wide array of behaviors.

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“…Two previous small, randomized, controlled trials of HBOT have been conducted in children with ASD, with one reporting improvements in overall symptoms (30% of children improved on the CGI-Improvement score in the HBOT group versus 8% in the placebo group), 52 and the other trial resulted in a finding of no effect. 53 Because one of the main postulated mechanisms for HBOT improving symptoms of autism is an anti-inflammatory effect, we conducted an open-label clinical trial in 10 children between the ages of 3 and 8 with ASD to determine if there were observable changes in detailed markers of inflammation after treatment. Children were treated with 40 sessions of HBOT, and a panel of 27 plasma cytokines was measured at baseline and after 40 days and 80 days (close-out) of treatment.…”

Section: Inflammation: Hyperbaric Oxygen Therapymentioning

confidence: 99%

Improving the Prediction of Response to Therapy in Autism

Bent

Hendren

2010

Neurotherapeutics

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Summary: Autism is a heterogeneous disorder involving complex mechanisms and systems occurring at diverse times. Because an individual child with autism may have only a subset of all possible abnormalities at a specific time, it may be challenging to identify beneficial effects of an intervention in double-blind, randomized, controlled trials, which compare the mean responses to treatments. Beneficial effects in a small subset of children may be obscured by the lack of effect in the majority. We review the evidence for several potential model systems of biochemical abnormalities that may contribute to the etiology of autism, we describe potential biomarkers or treatment targets for each of these abnormalities, and we provide illustrative treatment trials using this methodology. Potential model systems include immune over and under reactivity, inflammation, oxidative stress, free fatty acid metabolism, mitochondrial dysfunction, and excitotoxicity. Including potential biomarkers and targeted treatments in clinical trials for autism provides a potential method for limiting the heterogeneity of enrolled subjects, which may improve the power of studies to identify beneficial effects of treatments while also improving the understanding of the disease.

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Randomized trial of hyperbaric oxygen therapy for children with autism

Cited by 45 publications

References 23 publications

Fad, Pseudoscientific, and Controversial Interventions

Fad, Pseudoscientific, and Controversial Interventions

Controlled Evaluation of the Effects of Hyperbaric Oxygen Therapy on the Behavior of 16 Children with Autism Spectrum Disorders

Improving the Prediction of Response to Therapy in Autism

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