Randomized trial of high-dose rectal diclofenac suppository and epinephrine spray on duodenal papilla for prevention of post-endoscopic retrograde cholangiopancreatography pancreatitis

Dar, Hilal Ahmad; Shah, Altaf; Javid, Gul; Khan, Mushtaq Ahmad; Singh, Bhagat; Sheikh, Nadeem Ahmad; Ashraf, Aadil; Mohammad, Sozia

doi:10.1007/s12664-021-01161-z

Cited by 6 publications

(1 citation statement)

References 37 publications

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“…The ESGE 2020 guideline does not recommend its use in light of the controversial results of randomized controlled trials (RCTs) dealing with the subject. Two recent placebo-controlled RCTs investigated the efficacy of the use of epinephrine spray, combined with rectal administration of a non-steroidal anti-inflammatory drug (NSAID), in average- and high-risk patients [ 15 ] or unselected patients [ 16 ]. The PEP incidence in a multicenter RCT (548 patients) was 3.6% (n=10/275) in the epinephrine groups vs. 5.12% (n=14/273) in the placebo group, P=0.41.…”

Section: New Strategies Of Prophylaxis Since the Updated Esge Guidelinementioning

confidence: 99%

Update in preventing post-endoscopic retrograde cholangiopancreatography pancreatitis

Gellért

2024

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Of all the possible complications associated with endoscopic retrograde cholangiopancreatography (ERCP), acute pancreatitis undoubtedly represents the heaviest burden for patients and healthcare professionals. The overall incidence, ranging from 3.5% to around 10%, and annual estimated costs exceeding $150 million in the USA should signal caution for everyone carrying out ERCP. In-depth knowledge of the risk factors and the pharmacological and endoscopic treatment options is required to avoid this adverse event. In this review, we evaluate the relevant data published in the literature since the appearance of the latest recommendations of the leading gastroenterological societies. Thus, we intend to provide a comprehensive and up-to-date overview of the factors to consider and possible interventions applicable before and after the intervention to prevent the development of post-ERCP pancreatitis.

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Section: New Strategies Of Prophylaxis Since the Updated Esge Guidelinementioning

confidence: 99%

Update in preventing post-endoscopic retrograde cholangiopancreatography pancreatitis

Gellért

2024

aog

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Sham Feeding Induced Gastric Acid Secretion in Patients with Caustic Induced Esophageal Stricture

et al. 2021

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Combination Topical Epinephrine and Non-steroidal Inflammatory Drugs in the Prevention of Post-ERCP Pancreatitis: A Systematic Review

et al. 2022

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Randomized trial of high-dose rectal diclofenac suppository and epinephrine spray on duodenal papilla for prevention of post-endoscopic retrograde cholangiopancreatography pancreatitis

Cited by 6 publications

References 37 publications

Update in preventing post-endoscopic retrograde cholangiopancreatography pancreatitis

Update in preventing post-endoscopic retrograde cholangiopancreatography pancreatitis

Sham Feeding Induced Gastric Acid Secretion in Patients with Caustic Induced Esophageal Stricture

Combination Topical Epinephrine and Non-steroidal Inflammatory Drugs in the Prevention of Post-ERCP Pancreatitis: A Systematic Review

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