Randomized Trial of Exercise Therapy in Women Treated for Breast Cancer

Daley, Amanda; Crank, Helen; Saxton, John; Mutrie, Nanette; Coleman, Robert E.; Roalfe, Andrea

doi:10.1200/jco.2006.09.5083

Cited by 248 publications

(303 citation statements)

References 32 publications

(5 reference statements)

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“…Our results are similar to previous studies and meta-analysis [8,36,[51][52][53][54][55][56]. However, this is a post-treatment study, which may lead to greater changes than previous studies developed during chemotherapy [57], suggesting that the best opportunity to modify PROs should be after cancer (neo) adjuvant treatments.…”

supporting

confidence: 87%

Supervised physical exercise improves VO2max, quality of life, and health in early stage breast cancer patients: a randomized controlled trial

Casla

López-Tarruella

Jerez

et al. 2015

Breast Cancer Res Treat

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Breast cancer patients suffer impairment in cardiorespiratory fitness after treatment for primary disease, affecting patients' health and survival. The aim of this study was to evaluate the ability of a pragmatic exercise intervention to improve cardiorespiratory fitness of breast cancer patients after primary treatment. Between February 2013 and December 2014, 94 women with early stage (I-III) breast cancer, 1-36 months post-chemotherapy, and radiotherapy were randomly assigned to an intervention program (EX) combining supervised aerobic and resistance exercise (n = 44) or usual care (CON) (n = 45) for 12 weeks. Primary study endpoint was VO 2max . Secondary endpoints were muscle strength, shoulder range of motion, body composition, and quality of life (QoL). Assessments were undertaken at baseline, 12-week, and 6-month followups. Eighty-nine patients aged 29-69 years were assessed at baseline and 12 weeks. The EX group showed significant improvements in VO 2max , muscle strength, percent fat, and lean mass (p B 0.001 in all cases) and QoL compared with usual care (CON). Apart from body composition, improvements were maintained for the EX at 6-month follow-up. There were no adverse events during the testing or exercise intervention program. A combined exercise intervention produced considerable improvement in cardiorespiratory fitness, physical function, and quality of life in breast cancer patients previously treated with chemotherapy and radiation therapy. Importantly, most of these benefits were maintained 6 months after ceasing the supervised exercise intervention.

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supporting

confidence: 87%

Supervised physical exercise improves VO2max, quality of life, and health in early stage breast cancer patients: a randomized controlled trial

Casla

López-Tarruella

Jerez

et al. 2015

Breast Cancer Res Treat

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“…The recruitment strategy was successful, as the 25% recruitment rate was comparable to other U.K.-based exercise studies for women with breast cancer. 40,41 This suggests that it would be possible to recruit to a full trial of Nordic walking in this population. However, as 40 women were recruited from a single site, a fully powered trial would need to be multicenter.…”

Section: Discussionmentioning

confidence: 99%

“…40,41 There was an indication from the evaluation that group sessions were more acceptable than independent Nordic walking. In support of this, adherence was greater and most of the effect was seen in the first six weeks when Nordic walking was supervised.…”

Section: Discussionmentioning

confidence: 99%

Nordic Walking as an Exercise Intervention to Reduce Pain in Women With Aromatase Inhibitor–Associated Arthralgia: A Feasibility Study

Fields

Richardson

Hopkinson

et al. 2016

Journal of Pain and Symptom Management

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Context. Women taking aromatase inhibitors as treatment for breast cancer commonly experience joint pain and stiffness (aromatase inhibitoreassociated arthralgia [AIAA]), which can cause problems with adherence. There is evidence that exercise might be helpful, and Nordic walking could reduce joint pain compared to normal walking.Objectives. To determine the feasibility of a trial of Nordic walking as an exercise intervention for women with AIAA. Methods. A feasibility study was carried out in a sample of women with AIAA using a randomized control design. Women were randomized to exercise (six-week supervised group Nordic walking training once per week with an increasing independent element, followed by six weeks 4 Â 30 minutes/week independent Nordic walking); or enhanced usual care. Data were collected on recruitment, retention, exercise adherence, safety, and acceptability. The Brief Pain Inventory, GP Physical Activity Questionnaire, and biopsychosocial measures were completed at baseline, six and 12 weeks.Results. Forty of 159 eligible women were recruited and attrition was 10%. There was no increased lymphedema and no long-term or serious injury. Adherence was >90% for weekly supervised group Nordic walking, and during independent Nordic walking, >80% women managed one to two Nordic walking sessions per week. From baseline to study end point, overall activity levels increased and pain reduced in both the intervention and control groups.Conclusion. Our findings indicate that women with AIAA are prepared to take up Nordic walking, complete a six-week supervised course and maintain increased activity levels over a 12-week period with no adverse effects. J Pain Symptom Manage 2016;-:-e-. Ó

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“…Moreover, the participants maintained their physical activity levels once the program was completed. Three other studies [4,11,22] reported long-term results following an exercise intervention for cancer patients who had completed their cancer-related treatment. Similar to our findings in a mixed group of cancer survivors, Milne et al [22] showed that quality of life of breast cancer survivors was improved directly after and 3 months following a 12-week combined aerobic and resistance exercise intervention.…”

Section: Change (Points)mentioning

confidence: 99%

“…This effect may be partly due to the attention given to the participants during regularly telephone calls (every 3 weeks) during follow-up, whereas we did not approach our participants during follow-up. Daley et al [11] showed a beneficial effect on breast cancer survivors' quality of life directly following an 8-week physical training program when compared to control. Results were not maintained at 4-month follow-up.…”

Section: Change (Points)mentioning

confidence: 99%

Long-term effects on cancer survivors’ quality of life of physical training versus physical training combined with cognitive-behavioral therapy: results from a randomized trial

May

Korstjens

Weert

et al. 2008

Support Care Cancer

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Background We compared the effect of a 12-week groupbased multidisciplinary self-management rehabilitation program, combining physical training (twice weekly) and cognitive-behavioral therapy (once weekly) with the effect of 12-week group-based physical training (twice weekly) on cancer survivors' quality of life over a 1-year period. Materials and methods One hundred forty-seven survivors [48.8±10.9 years (mean±SD), all cancer types, medical treatment ≥3 months ago] were randomly assigned to either physical training (PT, n=71) or to physical training plus cognitive-behavioral therapy (PT+CBT, n=76). Quality of life and physical activity levels were measured before and immediately after the intervention and at 3-and 9-month post-intervention using the European Organization forResearch and Treatment of Cancer Quality of Life Questionnaire C30 questionnaire and the Physical Activity Scale for the Elderly, respectively. Results Multilevel linear mixed-effects models revealed no differential pattern in change of quality of life and physical activity between PT and PT+CBT. In both PT and PT+ CBT, quality of life and physical activity were significantly and clinically relevantly improved immediately following the intervention and also at 3-and 9-month post-intervention compared to pre-intervention (p<0.001). Conclusion Self-management physical training had substantial and durable positive effects on cancer survivors' quality of life. Participants maintained physical activity levels once the program was completed. Combining physical training with our cognitive-behavioral intervention Support Care Cancer (2009) did not add to these beneficial effects of physical training neither in the short-term nor in the long-term. Physical training should be implemented within the framework of standard care for cancer survivors.

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Randomized Trial of Exercise Therapy in Women Treated for Breast Cancer

Abstract: Exercise therapy had large, clinically meaningful, short-term beneficial effects on QoL in women treated for breast cancer; this finding cannot be attributable to attention, given that the exercise-placebo group did not report similar effects relative to usual care.

Cited by 248 publications

References 32 publications

Supervised physical exercise improves VO2max, quality of life, and health in early stage breast cancer patients: a randomized controlled trial

Supervised physical exercise improves VO2max, quality of life, and health in early stage breast cancer patients: a randomized controlled trial

Nordic Walking as an Exercise Intervention to Reduce Pain in Women With Aromatase Inhibitor–Associated Arthralgia: A Feasibility Study

Long-term effects on cancer survivors’ quality of life of physical training versus physical training combined with cognitive-behavioral therapy: results from a randomized trial

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