Randomized Trial of a Telephone-Based Weight Loss Intervention in Postmenopausal Women With Breast Cancer Receiving Letrozole: The LISA Trial

Abstract

A telephone-based LI led to significant weight loss that was still evident at 24 months, without adverse effects on QOL, hospitalizations, or medical events. Adequately powered randomized trials with cancer end points are needed.

Understanding and influencing the maintenance of physical activity and dietary behaviour change in breast cancer survivors

“…The majority of weight regain occurred during the six-month extended contact intervention (average regain of 0.2kg per month), with minimal change observed during the six-month period of no contact (average mean weight loss of -0.01kg). The amount of weight regain observed in this trial is better than that reported in trials without extended intervention contact (0.3kg per month; regain 50 per cent of weight loss; Curioni et al, 2005;Dansinger et al, 2007), and comparable to the regain of 0.1 to 0.3kg commonly reported during longer-term ongoing interventions (Goodwin et al, 2014;Group et al, 2006;Wadden et al, 2011) and extended contact interventions (Harris et al, 2013;Harvey-Berino et al, 2004;Perri et al, 2008;Svetkey et al, 2008;. Therefore, the current findings support the growing consensus that weight regain following the end of an initial intensive intervention is expected, but that extended contact can help to attenuate the magnitude of regain .…”

“…Of the two trials that reported maintenance outcomes following end-of-intervention, one reported ongoing weight loss at three-months follow-up (Campbell et al, 2012) while the other reported nearly half of initial weight loss was regained at six-months follow-up (Greenlee et al, 2013). The recently published Lifestyle Intervention in Adjuvant Treatment of Early Breast Cancer (LISA) trial randomised breast cancer survivors to a two-year weight loss intervention and reported participants lost an initial 5.3% of weight at six-months, but regained 65% of initial weight loss by two-years follow-up (Goodwin et al, 2014). There is support for the efficacy of behaviour change interventions in successfully initiating weight loss in breast cancer survivors, but less is known about how to promote successful longerterm weight loss maintenance.…”

“…With the exception of the LISA weight loss trial (Goodwin et al, 2014) and the WINS and the WHEL (Pierce et al, 2007a) dietary intervention trials, in which intervention contact continued (albeit at a reduced intensity) and follow-up assessments were conducted up to seven-years follow-up, there have been few studies reporting on maintenance of effects following an initial intervention . It is promising to see maintenance is being addressed in a number of currently ongoing long-term weight loss trials for breast cancer survivors, but these results are withstanding to date (Rack et al, 2010;Rock et al, 2013;Villarini et al, 2012).…”

“…A lessdeveloped evidence base supports the efficacy of dietary interventions in breast cancer survivors Pierce et al, 2007a), and suggests improvements in quality of life outcomes for women as a result of improved dietary behaviours (i.e., increased fruit and vegetable consumption; decreased fat intake; Mohammadi et al, 2013b;Rock et al, 2002). With the exception of two large scale dietary intervention trials Pierce et al, 2007a) and one ongoing weight loss intervention trial (Goodwin et al, 2014), there is a lack of evidence regarding whether short-term improvements in physical activity and dietary behaviours can be maintained in breast cancer survivors, with maintenance being broadly defined here as the evaluation of longterm outcomes, typically occurring after a period of no intervention contact.…”

A Lifestyle Intervention via Email in Minority Breast Cancer Survivors: Randomized Parallel-Group Feasibility Study (Preprint)

“…Several researchers have advocated for home-based interventions that may include both telephone counseling and tailored print materials [12,13]. While many home-based programs have led to significant improvements in healthy lifestyle behaviors [14][15][16][17][18][19][20], they are not always sustainable because telephone counseling and mass mailouts require significant personnel effort. Web-based approaches offer a potential to overcome both provider and participant (cost, time, and distance) barriers [21].…”