Randomized Study of the Effects of Zinc, Vitamin A, and Magnesium Co-supplementation on Thyroid Function, Oxidative Stress, and hs-CRP in Patients with Hypothyroidism

Rabbani, Elaheh; Golgiri, Fatemeh; Janani, Leila; Fallah, Soudabeh; Abiri, Behnaz; Vafa, Mohammadreza

doi:10.1007/s12011-020-02548-3

Cited by 30 publications

(25 citation statements)

References 28 publications

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“…In addition, serum hs-CRP levels were significantly decreased and plasma TAC levels were increased after 12 weeks of magnesium and zinc co-supplementation (13). However, in another RCT, the MDA and TAC levels were not found to be significantly altered after 10 weeks of magnesium, zinc, and vitamin A co-supplementation (50). Combined supplementation of magnesium and zinc had a strong synergistic effect on improving OS and inflammatory response in PCOS patients (8,13,49).…”

Section: Discussionmentioning

confidence: 89%

The effect of magnesium alone or its combination with other supplements on the markers of inflammation, OS and metabolism in women with polycystic ovarian syndrome (PCOS): A systematic review

Huang

et al. 2022

Front. Endocrinol.

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The objective of this systematic review is to synthesize the available evidence on the effectiveness of magnesium supplements on the markers of inflammation, oxidative stress (OS), and metabolism in PCOS patients and to provide a basis for its clinical treatment. Electronic databases (PubMed, Cochrane Library databases, Embase, Web of science, CMB, CNKI, VIP, Wan Fang and ClinicalTrials.gov) were searched from their inception until January 2022. Randomized controlled trials (RCTs) for PCOS undergoing therapy with magnesium supplementation alone or in combination with other agents. The primary outcomes were the markers of blood glucose and OS.363 patients from nine RCTs were included in the current systematic review. Four of the nine studies reported the effects of magnesium supplementation alone on OS or metabolic markers in women with PCOS. Whilemagnesium supplementation alone did not show any significant improvement in the markers of inflammation, OS or metabolism in PCOS, seven of the nine articles reported the effect of magnesium co-supplementation on OS or metabolic markers in PCOS patients. Magnesium combined with vitamin E or zinc-calcium-vitamin D significantly improved glucose and lipid metabolism in PCOS patients. Magnesium intake alone did not lead to a significant improvement in the markers of OS, blood glucose, or serum lipids in PCOS. However, magnesium combined with other supplements (vitamin E, zinc, zinc-calcium-vitamin D) significantly improved serum hs-CRP, insulin, HOMA-IR, TG, TC levels, and the improvement in OS markers was inconclusive. The effect of magnesium and melatonin supplementation on the markers of metabolism needs to be further verified.System Review RegistrationPROSPERO https://www.crd.york.ac.uk/PROSPERO/#myprospero, CRD42022303410.

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Section: Discussionmentioning

confidence: 89%

The effect of magnesium alone or its combination with other supplements on the markers of inflammation, OS and metabolism in women with polycystic ovarian syndrome (PCOS): A systematic review

Huang

et al. 2022

Front. Endocrinol.

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“…On the other hand, magnesium deficiency may also be associated with inflammation and increased concentration of free radicals. Inflammatory mediators and free radicals could induce oxidative DNA damage [ 36 , 37 ]. Previous studies have suggested that persons with endometriosis experience vascular inflammation [ 38 , 39 ].…”

Section: Resultsmentioning

confidence: 99%

ATR-IR Spectroscopy Application to Diagnostic Screening of Advanced Endometriosis

Kokot

Mazurek

Piwowar

et al. 2022

Oxidative Medicine and Cellular Longevity

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Endometriosis is one of the most common gynecological diseases among young women of reproductive age. Thus far, it has not been possible to define a parameter that is sensitive and specific enough to be a recognized biomarker for diagnosing this disease. Nonspecific symptoms of endometriosis and delayed diagnosis are impulses for researching noninvasive methods of differentiating endometriosis from other gynecological disorders. We compared three groups of individuals in our research: women with endometriosis (E), patients suffering from other gynecological disorders (nonendometriosis, NE), and healthy women from the control group (C). Partial least squares discriminant analysis (PLS-DA) models were developed based on selected serum biochemical parameters, specific regions of the serum’s infrared attenuated total reflectance (FTIR ATR) spectra, and combined data. Incorporating the spectral data into the models significantly improved differentiation among the three groups, with an overall accuracy of 87.5%, 97.3%, and 98.5%, respectively. This study shows that infrared spectroscopy and discriminant analysis can be used to differentiate serum samples among women with advanced endometriosis, women without this disease, i.e., healthy women, and, most importantly, also women with other benign gynecological disorders.

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“…In our study, participants indicated the positive effect of zinc supplementation on their health (especially hair condition), but clinical research did not find zinc supplementation in humans without substantial zinc deficiencies leading to regulation of thyroid hormone metabolism (Stolińska and Wolańska, 2012). According to Rabbani et al (2021) zinc co-supplementation may be beneficial in patients with hypothyroidism. The study showed that zinc, vitamin A, and magnesium supplementation resulted in significant increase in serum FT4 and lower levels of hs-CRP (Rabbani et al, 2021).…”

Section: Discussionmentioning

confidence: 99%

“…According to Rabbani et al (2021) zinc co-supplementation may be beneficial in patients with hypothyroidism. The study showed that zinc, vitamin A, and magnesium supplementation resulted in significant increase in serum FT4 and lower levels of hs-CRP (Rabbani et al, 2021).…”

Section: Discussionmentioning

confidence: 99%

Dietary supplements in hypothyroidism [pdf]

Woźniak¹,

Drzymała²,

Przysławski³

et al. 2021

Acta Sci Pol Technol Aliment

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Randomized Study of the Effects of Zinc, Vitamin A, and Magnesium Co-supplementation on Thyroid Function, Oxidative Stress, and hs-CRP in Patients with Hypothyroidism

Cited by 30 publications

References 28 publications

The effect of magnesium alone or its combination with other supplements on the markers of inflammation, OS and metabolism in women with polycystic ovarian syndrome (PCOS): A systematic review

The effect of magnesium alone or its combination with other supplements on the markers of inflammation, OS and metabolism in women with polycystic ovarian syndrome (PCOS): A systematic review

ATR-IR Spectroscopy Application to Diagnostic Screening of Advanced Endometriosis

Dietary supplements in hypothyroidism [pdf]

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