Randomized study of single early instillation of (2r)-4-o-tetrahydropyranyl-doxorubicin for a single superficial bladder carcinoma.

Feasibility of early intravesical instillation chemotherapy after transurethral resection of the bladder: A prospective evaluation in a consecutive series of 210 cases

“…As reported in other studies [6,7], the risks and side-effects of early postoperative instillation chemotherapy in this series were minor and without significant consequences, although in one case a causal relationship with StevensÁJohnson syndrome could not be excluded. Allergic skin reactions after exposure to intravesical chemotherapy have been reported to be in the range of 1Á3% [8,9].…”

Systematic Review and Individual Patient Data Meta-analysis of Randomized Trials Comparing a Single Immediate Instillation of Chemotherapy After Transurethral Resection with Transurethral Resection Alone in Patients with Stage pTa–pT1 Urothelial Carcinoma of the Bladder: Which Patients Benefit from the Instillation?

“…After review of 171 full texts, 13 RCTs published between 1985 and 2011 were eligible for inclusion [8,[17][18][19][20][21][22][23][24][25][26][27][28][29][30][31].…”

“…Four were single center [22,23,28,29] and seven were multicenter (1 multi-national), three with a central randomization [21,25,26] and four with envelopes or local randomization lists [8,18,20,27]. No studies were double blind.…”

Long-term Effect of Transurethral Resection of Bladder Tumor Combined with Intravesical Instillation of Pirarubicin on Immune Function in Superficial Bladder Cancer

“…Pirarubicin prevents DNA replication and transcription in cancer cells, therefore, cancer cells are prevented from dividing, thereby reducing the risk of recurrence [4] . In this study, the long-term effects of TURBT combined with intravesical instillation of pirarubicin were explored on immune function in patients with bladder cancer in order to provide a basis for clinical practice.…”

“…Currently, the commonly used drugs in clinical practice include pirarubicin and doxorubicin [14] . Pirarubicin can prevent DNA replication and transcription in cancer cells, thus, cancer cells are prevented from dividing, thereby reducing the risk of recurrence [4] .…”