Randomized Prospective Double-Blind Trial in Healing Chronic Diabetic Foot Ulcers: CT-102 activated platelet supernatant, topical versus placebo

Steed, David L.; Goslen, J. Blake; Holloway, Greg; Malone, J M; Bunt, T.J.; Webster, Marshall W.

doi:10.2337/diacare.15.11.1598

Cited by 184 publications

(185 citation statements)

References 15 publications

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“…Platelets, platelet-rich plasma (PRP), platelet lysates, platelet-derived growth factor (PDGF), and supernatants from activated platelets all have well-known stimulatory effects on mesenchymal cells in vitro (4-10) and in vivo (11). The clinical potential of platelet constituents is interesting and several clinical trials and observations on wound healing and bone formation have been published (12)(13)(14)(15)(16)(17)(18). Previously, it has also been described that mineralization and bone repair is pH dependent.…”

Section: Introductionmentioning

confidence: 99%

Variation of pH in lysed platelet concentrates influence proliferation and alkaline phosphatase activity in human osteoblast-like cells

et al. 2007

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Interestingly, we also found BMP-2 in platelet lysate. However BMP-2 was only present in LPB pH 4.0. We suggest, based on these experimental findings, that acidic milieu influence platelets to release growth factors more potent to stimulate osteoblast proliferation than neutral and alkaline platelet preparations. Lysed platelet concentrates prepared at an alkaline pH might release additional components with stimulating effects pH of platelet concentrate and growth stimulation 4 resulting in other features than cell proliferation. This is the first report, to our knowledge, about the presence of BMP-2 in platelet lysate and about a pH dependent stimulatory effect of lysed platelet concentrates on human osteoblast-like cell proliferation. Lysed platelet concentrates, preincubated in acidic or alkaline buffers, may benefit fracture healing, implant fixation and might also be advantageous in the treatment of wounds with platelet constituents; however, this has to be investigated in extended experimental and clinical settings.pH of platelet concentrate and growth stimulation 5

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Section: Introductionmentioning

confidence: 99%

Variation of pH in lysed platelet concentrates influence proliferation and alkaline phosphatase activity in human osteoblast-like cells

et al. 2007

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“…Previous studies of PRP have demonstrated antimicrobial activity against Escherichia coli, Staphylococcus aureus [31,32], including methicillin-resistant Staphylococcus aureus [31], Candida albicans [31] and Cryptococcus neoformans [33]. This suggests its role as antimicrobial and has the potential to eradicate the infective pathogens from the site and boost the healing process.…”

Section: Properties Of Platelet-rich Plasma Towards Wound Healing Andmentioning

confidence: 99%

Bio Technological Intervention with Platelet Rich Plasma for Assisted Regeneration of Sole

Shrivastava¹,

Naik²,

Patil³

et al. 2017

J Tissue Sci Eng

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With the advent of Regenerative medicine products in medicine, newer solutions are getting evolved for complex conditions. The Cellular therapies offer a new ray of hope by inducing regeneration of tissue at the site of damage. The cellular therapy led by platelet rich plasma (PRP) is one such key regenerative product. But there is a huge variability in its usage, particularly for wounds. The standardisation for clinical usage is not yet evolved, hence limiting the clinical application of the same.The authors have developed a standard protocol "STARS" therapy, which utilises PRP as biotechnological tool, re-engineering the damaged tissue and gradually assisting the regeneration.In this study we report 8 cases of wounds/ulcers over the sole being treated by it. The results are excellent and offer a milestone solution to non-healing wounds/ulcers over soles. These wounds are otherwise, very difficult to treat particularly as they are associated with high risks factors such as infection, Diabetes and old age. They are under constant pressure due to weight bearing and give way easily and do not heal.The bioenginreeing of the sole tissues through PRP led STARS intervention is safe, effective and easily reproducible.

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“…A very small study (in which the definition of healing was not clear) reported an apparent benefit of the product in neuropathic ulcers [51]. A large cohort study of neuropathic ulcers reported significant benefit but was weakened by being a retrospective analysis of a database of the outcome of patients treated with different doses and for different periods with a platelet-derived product, and compared with those who did not receive it but were otherwise managed but in no specified way [52].…”

Section: Platelets and Platelet-derived Productsmentioning

confidence: 99%

A systematic review of the effectiveness of interventions to enhance the healing of chronic ulcers of the foot in diabetes

Hinchliffe

Valk

Apelqvist

et al. 2008

Diabetes Metab. Res. Rev.

203

132

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SummaryThe outcome of management of diabetic foot ulcers is poor and there is uncertainty concerning optimal approaches to management. We have undertaken a systematic review to identify interventions for which there is evidence of effectiveness. A search was made for reports of the effectiveness of interventions assessed in terms of healing, ulcer area or amputation in controlled clinical studies published prior to December 2006. Methodological quality of selected studies was independently assessed by two reviewers using Scottish Intercollegiate Guidelines Network (SIGN) criteria. Selected studies fell into the following categories: sharp debridement and larvae; antiseptics and dressings; chronic wound resection; hyperbaric oxygen (HBO); reduction of tissue oedema; skin grafts; electrical and magnetic stimulation and ultrasound. Heterogeneity of studies prevented pooled analysis of results. Of the 2251 papers identified, 60 were selected for grading following full text review. Some evidence was found to support hydrogels as desloughing agents and to suggest that a systemic (HBO) therapy may be effective. Topical negative pressure (TNP) may promote healing of post-operative wounds, and resection of neuropathic plantar ulcers may be beneficial. More information was needed to confirm the effectiveness and cost-effectiveness of these and other interventions. No data were found to justify the use of any other topically applied product or dressing, including those with antiseptic properties. Further evidence to substantiate the effect of interventions designed to enhance the healing of chronic ulcers is urgently needed. Until such evidence is available from robust trials, there is limited justification for the use of more expensive treatments and dressings.

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Randomized Prospective Double-Blind Trial in Healing Chronic Diabetic Foot Ulcers: CT-102 activated platelet supernatant, topical versus placebo

Abstract: CT-102 significantly accelerated wound closure in diabetic leg ulcers when administered as part of a comprehensive program for the healing of chronic ulcers.

Cited by 184 publications

References 15 publications

Variation of pH in lysed platelet concentrates influence proliferation and alkaline phosphatase activity in human osteoblast-like cells

Variation of pH in lysed platelet concentrates influence proliferation and alkaline phosphatase activity in human osteoblast-like cells

Bio Technological Intervention with Platelet Rich Plasma for Assisted Regeneration of Sole

A systematic review of the effectiveness of interventions to enhance the healing of chronic ulcers of the foot in diabetes

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