Randomized placebo-controlled clinical trial showed cold atmospheric argon plasma relieved acute pain and accelerated healing in herpes zoster

Isbary, Georg; Shimizu, Tetsuji; Zimmermann, Julia L.; Heinlin, J.; Alzaabi, Saeed; Rechfeld, M.; Morfill, G. E.; Karrer, Sigrid; Stolz, Wilhelm

doi:10.1016/j.cpme.2014.07.001

Cited by 53 publications

(26 citation statements)

References 27 publications

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“…Besides a significant reduction in bacterial colonization in comparison to standard treatment, no side effects associated with CAP therapy were found after a total of 291 treatments. In the treatment of pruritus, skin graft sites and herpes zoster, no relevant side effects were registered either [49][50][51]. Brehmer et al [52] reported on successful plasma therapy of chronic venous leg ulcers in a prospective, controlled clinical study using PlasmaDerm ® .…”

Section: Discussionmentioning

confidence: 99%

Long-Term Risk Assessment for Medical Application of Cold Atmospheric Pressure Plasma

et al. 2020

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Despite increasing knowledge gained based on multidisciplinary research, plasma medicine still raises various questions regarding specific effects as well as potential risks. With regard to significant statements about in vivo applicability that cannot be prognosticated exclusively based on in vitro data, there is still a deficit of clinical data. This study included a clinical follow-up of five probands who had participated five years previously in a study on the influence of cold atmospheric pressure plasma (CAP) on the wound healing of CO2 laser-induced skin lesions. The follow-up included a complex imaging diagnostic involving dermatoscopy, confocal laser scanning microscopy (CLSM) and hyperspectral imaging (HSI). Hyperspectral analysis showed no relevant microcirculatory differences between plasma-treated and non-plasma-treated areas. In summary of all the findings, no malignant changes, inflammatory reactions or pathological changes in cell architecture could be detected in the plasma-treated areas. These unique in vivo long-term data contribute to a further increase in knowledge about important safety aspects in regenerative plasma medicine. However, to confirm these findings and secure indication-specific dose recommendations, further clinical studies are required.

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Section: Discussionmentioning

confidence: 99%

Long-Term Risk Assessment for Medical Application of Cold Atmospheric Pressure Plasma

et al. 2020

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“…Additional important arguments for CAP tissue treatment are (i) its low invasiveness, (ii) the absence of treatment associated pain or discomfort, and (iii) the overall brilliant tolerance and acceptance in patients [Isbary et al, 2013c[Isbary et al, , 2014Heinlin et al, 2013;Metelmann et al, 2015]. A study by Partecke et al [2012] estimated CAP-induced apoptosis only in the uppermost cell layers with a depth of effective tissue penetration of a maximum of 60 mm [Partecke et al, 2012].…”

Section: Potential Applications Of Cap Treatment and Its Momentousnesmentioning

confidence: 99%

Virucide properties of cold atmospheric plasma for future clinical applications

Weiß

Daeschlein

Krämer

et al. 2017

Journal of Medical Virology

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Cold atmospheric plasma (CAP) has been repeatedly identified to bear powerful microbicidal efficacy on bacteria including multidrug resistant organisms and fungi on non-living surfaces, in biofilms as well as on contaminated and infected tissues. CAP furthermore was found to stimulate wound healing in chronic wounds and exerted anti-neoplastic effects on numerous tumor entities. Thus, CAP represents a promising medical tool for many clinical and therapeutic issues. Studies about CAP effects on virus particles recently were in arrears, but to date increasingly move into the focus of interest. Apparently, CAP treatment is followed by a promising virus inactivation and contributes to tissue regeneration. Here we review the current state of science concerning the so far investigated CAP effects on different virus species and virus-associated disorders. J. Med. Virol. 89:952-959, 2017. © 2017 Wiley Periodicals, Inc.

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“…Nabrojeni učinci su posljedica djelovanja ROS-a i RNS/RONS-a, kao i plazmom induciranih promjena u vlažnom okolišu stanica i tkiva 5 . Uz tretiranje kroničnih rana, u novije vrijeme objavljuju se rezultati primjene CAP-a i u drugim područjima dermatologije, kao što su ublažava-nje bolova i ubrzavanje liječenja herpes zostera te tretiranje ekcema i psorijaze [38][39][40] .…”

Section: Dermatologijaunclassified

Plasma applications in medicine and dentistry

Mance

2017

Med. flum.

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Sažetak. U fizici, plazma je ioniziran, kvazineutralan plin za koji se često kaže da je četvrto stanje materije. Dugo vremena se plazma u medicini koristila zbog svojih termalnih svojstava, primjerice za sterilizaciju kirurškog i medicinskog pribora te za rezanje i kauterizaciju tkiva. Generiranjem hladne plazme u atmosferskim uvjetima započelo je novo razdoblje u primjeni plazme u biomedicini. Plazma medicina novo je interdisciplinarno znanstveno područje koje kombinira spoznaje fizike plazme s biomedicinskim i kliničkim znanostima. Hladna atmosferska plazma emitira elektromagnetno zračenje te se sastoji od mnoštva nabijenih i nenabijenih čestica, među kojima su najznačajnije reaktivne kisikove i dušikove vrste. Smatra se da su upravo reaktivne kisikove vrste najvažnije za biološke učinke plazme kao što su inaktivacija mikroorganizama i biofilmova. U dermatologiji se pokazalo da hladna atmosferska plazma pozitivno utječe na zacjeljivanje kroničnih rana. Prvi instrumenti za primjenu hladne plazme na ljudima već su i komercijalno dostupni. Primjena hladne plazme ima velik potencijal za primjenu u onkologiji, ali i u stomatologiji. Mnogobrojne studije dale su vrlo obećavajuće rezultate za primjenu hladne plazme u medicini, no treba imati na umu da mehanizmi međudjelovanja plazme s biološkim tkivom još uvijek nisu u potpunosti razjašnjeni, da nema dogovorom prihvaćene definicije doze koju plazma predaje materiji, da još uvijek nema standardiziranih instrumenata za generiranje i karakterizaciju plazme te da za pravu procjenu potencijala primjene atmosferske plazme u medicini i stomatologiji nedostaje više detaljnih in vivo studija.Ključne riječi: dermatologija; onkologija; plazma; stomatologija Abstract. Physical plasma is an ionized, quasi-neutral gas. It is often said to be the fourth state of matter. For a long time, plasma was used in medicine exclusively because of its thermal properties for sterilization purposes of surgical equipment and medical supplies, and also to cut and cauterize tissue. The possibility to generate cold plasma in atmospheric conditions marked the beginning of a completely new era in the application of plasma in biomedicine. Plasma medicine is a new interdisciplinary field of science that combines the knowledge of plasma physics to biomedical and clinical sciences. Cold atmospheric plasma emits electromagnetic radiation and it consists out of charged and uncharged particles, among those reactive oxygen and nitrogen species are the most important ones. It is considered that reactive oxygen species cause the most important biological plasma effects, such as inactivation of microorganisms and biofilms. It has been shown in dermatology that cold atmospheric plasma has a healing effect on chronic wounds. First instruments for the application of cold plasma in humans are already commercially available. Cold plasma has a great potential for application in oncology and in dentistry. Numerous studies have yielded very promising results for the application of cold plasma in medicine, but it should ...

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Randomized placebo-controlled clinical trial showed cold atmospheric argon plasma relieved acute pain and accelerated healing in herpes zoster

Cited by 53 publications

References 27 publications

Long-Term Risk Assessment for Medical Application of Cold Atmospheric Pressure Plasma

Long-Term Risk Assessment for Medical Application of Cold Atmospheric Pressure Plasma

Virucide properties of cold atmospheric plasma for future clinical applications

Plasma applications in medicine and dentistry

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