Randomized, investigator-blinded, controlled clinical study with lice shampoo (Licener®) versus dimethicone (Jacutin® Pedicul Fluid) for the treatment of infestations with head lice

Semmler, Margit; Abdel-Ghaffar, Fathy; Gestmann, Falk; Abdelaty, Mohammed Hassan; Rizk, Ibrahim; Al‐Quraishy, Saleh; Lehmacher, Walter; Hoff, Norman-Philipp

doi:10.1007/s00436-017-5461-7

Cited by 10 publications

(6 citation statements)

References 31 publications

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“…Additionally, Arslan et al 39 reported a genotoxic and cytotoxic potential for mixtures containing piperonyl butoxide. Our results agree with a previous report 32 that revealed the decreased safety and efficacy of medical treatments for head lice. Meister and Ochsendorf 40 observed the decreasing efficacy of permethrin and reported the successful treatment of head lice with ovicidal dimethicones.…”

Section: Medical Treatments Of Infected Studentssupporting

confidence: 94%

“…A comparison with the surrounding and international countries, revealed the prevalence of head lice in children from kindergarten and schools from Israel 27 , children from schools in Egypt 9 , children from schools in Saudi Arabia 28 , children from schools in Iran 21 , children from Jordan 29 , children from the UK 30 , USA 31 and Germany 32 . However, the prevalence among international and/or surrounding countries is quite different due to different educational levels, medical care, weather and living conditions.…”

Section: Resultsmentioning

confidence: 99%

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The Prevalence of Head Lice and Health Consequence of Their Medical Treatments among Female Students from Different Schools

Nahha¹

2019

Int. J. Pure App. Biosci.

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Background and Objectives: Head lice infestation becomes a pressing problem around the world. This study characterized the prevalence of head lice and health consequences associated with their medical treatment among female students. Materials and Methods: A cluster of five schools was selected randomly in nine locations in Gaza Strip. The abundance of head lice among students was determined manually using a special crown. Each female student was required to comb her hair five times over a white sheet of A4 paper. Each sheet was collected and coded by the name of the student and kept in covered plastic cups. The samples were transferred to the lab for analysis. The second part of the study included voluntarily collection of a 5 mL blood and urine sample. Results: The highest prevalence of head lice (18%) among primary schools in the middle zone cluster, followed by Bait Lahia and Khan Younis clusters, whereas the lowest prevalence was found in the Gaza cluster (7.14%). Blood analysis showed an elevation of aspartate aminotransferase (AST) and urea levels and a reduction in acetylcholinesterase (AChE) activity. Pesticide residue analysis showed positive values in head lice patients who intensively used medical treatments. Conclusion: The results of this study showed that head lice medical treatment has health consequences.

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Section: Medical Treatments Of Infected Studentssupporting

confidence: 94%

Section: Resultsmentioning

confidence: 99%

The Prevalence of Head Lice and Health Consequence of Their Medical Treatments among Female Students from Different Schools

Nahha¹

2019

Int. J. Pure App. Biosci.

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“…Dimethicone can be used in children more than 2 years of age. Furthermore, after 1 day of treatment with 100% dimethicone, 98.3% of subjects were free of live lice 9,10 . Dimethicone avoids pesticide exposure and resistance issues, 11 but the mechanism of action remains unclear 7 because head lice are reported to live in anoxic conditions for 8–14 h 12 .…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, after 1 day of treatment with 100% dimethicone, 98.3% of subjects were free of live lice. 9,10 Dimethicone avoids pesticide exposure and resistance issues, 11 but the mechanism of action remains unclear 7 because head lice are reported to live in anoxic conditions for 8-14 h. 12 In addition, the expansion of kdr mutations in head lice has been reported in Denmark 13 and Mexico. 14 Hence, effective therapeutic strategies against infestations need to be established.…”

Section: Introductionmentioning

confidence: 99%

Efficacy and safety of a combination regimen of phenothrin and ivermectin lotion in patients with head lice in Okinawa, Japan

Komoda

Yamaguchi

Takahashi

et al. 2020

The Journal of Dermatology

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In Japan, pyrethroid-resistant head lice have been increasing; however, only 0.4% phenothrin, a pyrethroid drug, is available as an over the counter formulation. In recent years, Sumithrin â Lotion containing 5% phenothrin (PHT) was approved for scabies. In the USA, Sklice â Lotion containing 0.5% ivermectin (IVM) is used for the treatment of pyrethroid-resistant head lice. Therefore, to enhance the treatment of head lice in Japan, we conducted a clinical study to confirm the efficacy and safety of a combination regimen of PHT and IVM (PI regimen). Twelve cases were enrolled and PHT was applied to all patients on day 1. On day 8, five patients (41.7%) were lice free, and PHT was applied again. Notably, seven patients were not lice free and were switched to IVM. The rate of patients who were lice free on the PI regimen, which was the primary end-point, was 75.0% on day 15 and 91.7% on day 22. No adverse events were reported. A genetic analysis of the head lice collected at each visit revealed a kdr mutation in all patients. These results suggest that the PI regimen is safe and effective for the treatment of pyrethroid-resistant head lice in Japan.

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“…There is a tendency to shorten the application time in order to increase treatment compliance. Application times as short as 10 min have been described to be effective for products based on mineral oil [24] and neem seed extract [25]. Given the high socio-economic and psycho-social burden of head louse infestations, effective, reliable, safe and rapid treatment options are needed.…”

Section: Introductionmentioning

confidence: 99%

High efficacy of a dimeticone-based pediculicide following a brief application: in vitro assays and randomized controlled investigator-blinded clinical trial

et al. 2019

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BackgroundIncreasing resistance of head lice against neurotoxic agents and safety concerns have led to the search for treatment alternatives. Dimeticones with a physical mode of action are safe, and bear a reduced risk for the development of resistance.MethodsWe performed in vitro bioassays to assess pediculicidal and ovicidal activities of a new dimeticone-based product, and a randomized controlled clinical trial to assess efficacy, following 10 min application. Of 153 individuals screened, 100 participants with active head louse infestations were randomly assigned to treatment with either a dimeticone-based test product, or a 0.5% permethrin-based reference product (50 participants per group). Participants received two topical applications of either the test (10 min) or reference products (45 min) at days 0 and 7 or 8. Outcome measures included the efficacies of treatment and their safety, as well as global and local tolerability at baseline, and days 1, 7, and 10.ResultsAfter 10 min exposure, all lice treated with the dimeticone test product were classified as non-viable in the in vitro assay. Ovicidal activity after treatment of eggs with the dimeticone test product was 96.8%. In the clinical trial, 96 patients completed all study visits. In the full analysis set (FAS) population, on day 1 after one application, 98% of patients were cured in the test group, as compared to 84% cured in the reference group. All participants in both groups were free of head lice on day 10, following two applications (100% cure rate). In total, 42 adverse events (AEs) in 23 patients of both treatment groups were recorded, with the majority of AEs classified as mild.ConclusionsWe have shown a high level of pediculicidal and ovicidal activity, and clinical efficacy and safety, of a brief application of a new dimeticone-based product. The short application time and reduced risk for the development of resistance are key drivers for improved patients’ compliance.Trial registrationEU Clinical Trials Register EudraCT 2016–004635-20. Registered 14 November 2016.

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Randomized, investigator-blinded, controlled clinical study with lice shampoo (Licener®) versus dimethicone (Jacutin® Pedicul Fluid) for the treatment of infestations with head lice

Cited by 10 publications

References 31 publications

The Prevalence of Head Lice and Health Consequence of Their Medical Treatments among Female Students from Different Schools

The Prevalence of Head Lice and Health Consequence of Their Medical Treatments among Female Students from Different Schools

Efficacy and safety of a combination regimen of phenothrin and ivermectin lotion in patients with head lice in Okinawa, Japan

High efficacy of a dimeticone-based pediculicide following a brief application: in vitro assays and randomized controlled investigator-blinded clinical trial

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