Randomized, Double-Masked Study of Cyclosporine Compared to Prednisolone in the Treatment of Endogenous Uveitis

Nussenblatt, Robert B.; Palestine, Alan G.; Chan, Chi Chao; Stevens, Garth; Mellow, Susan D.; Green, Sylvan B.

doi:10.1016/s0002-9394(14)76692-9

Cited by 157 publications

(65 citation statements)

References 12 publications

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“…Strong association of HLA-A*29, 2 lymphocytic infiltration in the choroid 17 as well as the beneficial effects of immunosuppressive agents such as cyclosporine 54 in BCR clearly demonstrate the central role for an HLA-A29-restricted CTL response. The molecular or antigenic mimicry between the 'external' and 'self' peptide ligands of HLA-A29 may result in some activated CTLs having a response against self, which in turn may lead to autoimmunity.…”

Section: Discussionmentioning

confidence: 91%

Combination of KIR and HLA gene variants augments the risk of developing birdshot chorioretinopathy in HLA-A*29-positive individuals

Levinson

Luo

et al. 2008

Genes Immun

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Section: Discussionmentioning

confidence: 91%

Combination of KIR and HLA gene variants augments the risk of developing birdshot chorioretinopathy in HLA-A*29-positive individuals

Levinson

Luo

et al. 2008

Genes Immun

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“…Details of the excluded full-text articles with reasons for exclusion are presented in Appendix 2. Seventeen potentially relevant articles (relating to 16 studies) were retained for potential inclusion in meta-analyses; 13 studies 32,33,[57][58][59][60][61][62][63][64][65][66][67] were related to comparators within the scope of the review and three studies (four articles [46][47][48]68 ) evaluated ADA or DEX 700. It was not possible to include any of the 13 studies of comparators within a NMA (the reasons why this was not possible, and a summary of the 13 studies, are provided in Indirect comparison of treatments: rationale for not undertaking and Table 24).…”

Section: Results Of the Clinical Effectiveness Reviewmentioning

confidence: 99%

“…In addition to the trials of DEX 700 (HURON 48 ) and ADA (VISUAL I 46 and II 47 ), 13 additional trials of relevant comparators were identified. 32,33,[57][58][59][60][61][62][63][64][65][66][67] Unfortunately, it was considered infeasible and inappropriate to conduct a NMA for the reasons outlined in Table 24. However, a brief summary of all identified trials of relevant comparators is provided in this section for information: study characteristics are provided in Table 25 and a summary of reported outcomes is provided in …”

Section: Consideration Of Indirect Comparisons For All Studies Of CLImentioning

confidence: 99%

A systematic review and economic evaluation of adalimumab and dexamethasone for treating non-infectious intermediate uveitis, posterior uveitis or panuveitis in adults

Squires

Poku

Bermejo

et al. 2017

Health Technol Assess

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Declared competing interests of authors: Fahd Quhill has received personal fees from Allergan for participation in medical education and training, and has participated in advisory boards given his clinical expertise in the role of steroids in diabetic macular oedema. He has also received support from Allergan to attend international conferences.Published November 2017 DOI: 10.3310/hta21680 This report should be referenced as follows: This journal is a member of and subscribes to the principles of the Committee on Publication Ethics (COPE) (www.publicationethics.org/).Editorial contact: journals.library@nihr.ac.ukThe full HTA archive is freely available to view online at www.journalslibrary.nihr.ac.uk/hta. Print-on-demand copies can be purchased from the report pages of the NIHR Journals Library website: www.journalslibrary.nihr.ac.uk Criteria for inclusion in the Health Technology Assessment journalReports are published in Health Technology Assessment (HTA) if (1) they have resulted from work for the HTA programme, and (2) they are of a sufficiently high scientific quality as assessed by the reviewers and editors.Reviews in Health Technology Assessment are termed 'systematic' when the account of the search appraisal and synthesis methods (to minimise biases and random errors) would, in theory, permit the replication of the review by others. HTA programmeThe HTA programme, part of the National Institute for Health Research (NIHR), was set up in 1993. It produces high-quality research information on the effectiveness, costs and broader impact of health technologies for those who use, manage and provide care in the NHS. 'Health technologies' are broadly defined as all interventions used to promote health, prevent and treat disease, and improve rehabilitation and long-term care.The journal is indexed in NHS Evidence via its abstracts included in MEDLINE and its Technology Assessment Reports inform National Institute for Health and Care Excellence (NICE) guidance. HTA research is also an important source of evidence for National Screening Committee (NSC) policy decisions.For more information about the HTA programme please visit the website: http://www.nets.nihr.ac.uk/programmes/hta This reportThe research reported in this issue of the journal was commissioned and funded by the HTA programme on behalf of NICE as project number 15/64/07. The protocol was agreed in June 2016. The assessment report began editorial review in December 2016 and was accepted for publication in May 2017. The authors have been wholly responsible for all data collection, analysis and interpretation, and for writing up their work. The HTA editors and publisher have tried to ensure the accuracy of the authors' report and would like to thank the reviewers for their constructive comments on the draft document. However, they do not accept liability for damages or losses arising from material published in this report.This report presents independent research funded by the National Institute for Health Research (NIHR). The views and opinions expre...

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“…Corticosteroids administered either by the periocular route or systemically have been suggested [7][8][9] . In addition, immunosuppression may be required to improve inflammation and CME [10,11] . Pars plana vitrectomy has also been shown to improve CME and vision in selected cases [12][13][14] , and intravitreal bevacizumab was recently introduced as a further treatment option [15,16] .…”

Section: Introductionmentioning

confidence: 99%

Intravitreal and Orbital Floor Triamcinolone Acetonide Injections in Noninfectious Uveitis: A Comparative Study

Roesel

Gutfleisch²,

Heinz³

et al. 2009

Ophthalmic Res

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Purpose: To compare the effect of orbital floor (OFTA) or intravitreal (IVTA) administration of triamcinolone acetonide on visual acuity and chronic cystoid macular edema (CME) in patients with uveitis. Methods: Retrospective study of patients suffering from chronic noninfectious uveitis in whom CME (n = 97) did not respond to systemic corticosteroids and/or immunosuppression combined with acetazolamide. Patients received a single injection of either IVTA (n = 48, group 1) or OFTA (n = 49, group 2). Best-corrected visual acuity, macular edema (fluorescein angiography), uveitis activity, ocular hypertension, and cataract formation were analyzed over the course of 1 year. Results: Improvement in visual acuity (≥2 lines, LogMAR) was noted in 50% (IVTA) and 34% (OFTA) after 3 months (p = 0.23), and in 18% (IVTA) and 20% (OFTA) after 12 months. CME improved in 100% (IVTA) and 76% (OFTA) of the eyes within the first month postoperatively (p = 0.36). Macular edema was reduced in 100% (group 1) and 20% (group 2) after 3 months (p < 0.01). At 1 year, cataract progression was noted in 68% (IVTA) and 27% (OFTA) (p < 0.01). Increased intraocular pressure (>21 mm Hg) was detected in 21% (IVTA) and 0% (OFTA) at 4 weeks (p < 0.01) after injection. Conclusion: Uveitic CME and visual acuity not responding to systemic immunosuppression and acetazolamide may improve after an IVTA and OFTA injection. The effect is mostly transient. While the IVTA injections were more effective for improving CME, ocular hypertension and cataracts developed more often.

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Randomized, Double-Masked Study of Cyclosporine Compared to Prednisolone in the Treatment of Endogenous Uveitis

Cited by 157 publications

References 12 publications

Combination of KIR and HLA gene variants augments the risk of developing birdshot chorioretinopathy in HLA-A*29-positive individuals

Combination of KIR and HLA gene variants augments the risk of developing birdshot chorioretinopathy in HLA-A*29-positive individuals

A systematic review and economic evaluation of adalimumab and dexamethasone for treating non-infectious intermediate uveitis, posterior uveitis or panuveitis in adults

Intravitreal and Orbital Floor Triamcinolone Acetonide Injections in Noninfectious Uveitis: A Comparative Study

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