Randomized Double-Blind Study With Prednisone in Sydenham’s Chorea

An update on the treatment of Sydenham’s chorea: the evidence for established and evolving interventions

“…At best the condition lasts for 6 months but more usually it has a relapsing course for up to 2 years [Paz et al 2006;Walker et al 2005]. At worst it may evolve into a chronic movement disorder [Paz et al 2006;Walker et al 2005]. Variation in the duration of chorea and a lack of methods to quantify the severity together with the lack of a therapeutic index has made evaluation of therapy difficult [Aron et al 1965].…”

“…Twenty two children treated with steroids were compared with 15 placebo controls in a randomized, double-blind, parallel study [Paz et al 2006]. Two milligrams per kilogram of prednisone was given for 4 weeks and then tapered.…”

Conventional and intravenous immunoglobulin therapy in paediatric antiphospholipid antibodies-related chorea

“…In the following eight to 12 weeks these patients showed a significant reduction in chorea movements compared with a 15-patient placebo group. 17 Teixera et al first reported on the use of intravenous methylprednisolone treatment, followed by oral prednisone. 18 Fusco et al showed in a four-year observational study the beneficial use of intravenous methylprednisolone (25 mg/kg) in 10 patients with a paralytic form of SC for five days, followed by oral deflazacort therapy (0.9 mg/kg/day).…”

The usefulness of immunotherapy in pediatric neurodegenerative disorders: A systematic review of literature data

“…38 Another retrospective study, reported decreased duration of chorea in rheumatic fever patients, with prednisone treatment at standard doses compared to no treatment (4 vs. Nine weeks, respectively). 39 Later, a 4-year follow-up of on 10 patients with severe paralytic form of refractory SC (no response to conventional symptomatic therapies) treated with intravenous methylprednisolone and oral deflazacort, showed a significant improvement in pathologic children.…”