Randomized, Double-Blind, Placebo-Controlled Trial of Vitamin D Supplementation in the Build-up Phase of House Dust Mite-Specific Immunotherapy

Chiewchalermsri, Chirawat; Sangkanjanavanich, Sasipa; Pradubpongsa, Panitan; Mitthamsiri, Wat; Jaisupa, Nattapon; Jindarat, Sarawut; Buranapraditkun, Supranee; Jacquet, Alain; Sangasapaviliya, Atik; Boonpiyathad, Tadech

doi:10.4168/aair.2023.15.3.336

Cited by 2 publications

(2 citation statements)

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“…A study conducted in Bangkok, Thailand ( 147 ), demonstrated that, compared to a placebo, adult patients allergic to HDMs who received subcutaneous AIT and supplemented with vitamin D experienced significantly reduced symptom-drug scores and increased treatment response rates. This improvement in allergic symptoms is thought to be achieved by vitamin D significantly reducing the quantity of dysfunctional regulatory T cells (CRTH2+Treg).…”

Section: The Clinical Efficacy Of Vitamin D Supplementation In Allerg...mentioning

confidence: 99%

Vitamin D and allergic diseases

Zhang,

Xu,

Zhu

2024

Front. Immunol.

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In recent years, the relationship between vitamin D and allergic diseases has received widespread attention. As a fat-soluble vitamin, vitamin D plays a crucial role in regulating the immune system and may influence the onset and progression of diseases such as atopic dermatitis, allergic rhinitis, and asthma. To understand the underlying mechanisms, we have summarized the current research on the association between vitamin D and allergic diseases. We also discuss the impact of vitamin D on the immune system and its role in the course of allergic diseases, particularly focusing on how vitamin D supplementation affects the treatment outcomes of these conditions. We aim to provide a theoretical basis and practical guidance for optimizing the management and treatment of allergic diseases by modulating vitamin D levels.

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Section: The Clinical Efficacy Of Vitamin D Supplementation In Allerg...mentioning

confidence: 99%

Vitamin D and allergic diseases

Zhang,

Xu,

Zhu

2024

Front. Immunol.

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“…In a randomized, controlled clinical trial including children with allergic rhinitis, vitamin D supplementation combined with grass pollen sublingual immunotherapy was more effective in reducing nasal and asthma symptoms than grass pollen sublingual immunotherapy alone [ 168 ]. In patients with allergic rhinitis and vitamin D deficiency, vitamin D supplementation in the build-up phase of subcutaneous allergen immunotherapy with house dust mite extract significantly decreased the symptom–medication score of allergic rhinitis compared to subcutaneous allergen immunotherapy alone [ 169 ]. In a previous double-blind, placebo-controlled, randomized clinical trial, repeated intradermal injections of immune complexes made of house dust mite antigens and autologous antibodies to house dust mite antigens produced significant clinical improvement in patients with AD [ 170 ].…”

Section: Combinations Of Different Modalities Activating Regulatory T...mentioning

confidence: 99%

Regulatory T Cell-Targeted Immunomodulatory Therapy for Long-Term Clinical Improvement of Atopic Dermatitis: Hypotheses and Perspectives

Nahm

2023

Life

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Atopic dermatitis (AD) is a chronically relapsing inflammatory skin disorder characterized by itching and eczematous lesions. It is often associated with a personal or familial history of allergic diseases. Allergic inflammation induced by immunoglobulin E and T-helper type 2 (Th2) cell responses to common environmental agents has been suggested to play an essential role in AD pathogenesis. The standard therapies for AD, including topical or systemic agents, focus on controlling skin inflammation. Recently developed monoclonal antibody to interleukin-4 receptor alpha or Janus kinase inhibitors can provide significant clinical improvements in patients with AD by inhibiting Th2 cell-mediated skin inflammation. However, the clinical efficacy of the Th2 cell-targeted therapy is transient and incomplete in patients with AD. Patients with AD are seeking a permanent cure. Therefore, the development of novel immunomodulatory strategies that can improve a long-term clinical outcome and provide a long-term treatment-free clinical remission of AD (disease-modifying therapy) is needed. Regulatory T (Treg) cells play a critical role in the maintenance of immune tolerance and suppress the development of autoimmune and allergic diseases. This review provides three working hypotheses and perspectives for the treatment of AD by Treg cell activation. (1) A decreased number or function of Treg cells is a critical event that causes the activation of Th2 cells, leading to the development and maintenance of AD. (2) Activation of Treg cells is an effective therapeutic approach for AD. (3) Many different immunomodulatory strategies activating Treg cells can provide a long-term clinical improvement of AD by induction of immune tolerance. The Treg cell-targeted immunomodulatory therapies for AD include allergen immunotherapy, microbiota, vitamin D, polyvalent human immunoglobulin G, monoclonal antibodies to the surface antigens of T cell or antigen-presenting cell, and adoptive transfer of autologous Treg cells or genetically engineered Treg cells expanded in vitro.

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Randomized, Double-Blind, Placebo-Controlled Trial of Vitamin D Supplementation in the Build-up Phase of House Dust Mite-Specific Immunotherapy

Cited by 2 publications

References 35 publications

Vitamin D and allergic diseases

Vitamin D and allergic diseases

Regulatory T Cell-Targeted Immunomodulatory Therapy for Long-Term Clinical Improvement of Atopic Dermatitis: Hypotheses and Perspectives

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