Randomized, double-blind, placebo-controlled trial of nicotine replacement therapy in pregnancy

Kapur, Bhushan; Hackman, Richard; Selby, Peter; Klein, Julia; Koren, Gideon

doi:10.1016/s0011-393x(01)80011-4

Cited by 68 publications

(52 citation statements)

References 6 publications

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“…Of those, three articles [21][22][23] were excluded for the following reasons: not a comparison study (n = 1); 21 a study not related to pharmacotherapy (n = 1); 22 a study sharing an identical population with the study included in this analysis (n = 1). 23 Seven studies [9][10][11][12][13][14][15] were included in the final analysis.…”

Section: Methodsmentioning

confidence: 99%

“…8 The efficacy and safety of pharmacotherapy for smoking cessation has been established in the general population, but not in pregnant smokers. Although several studies [9][10][11][12][13][14][15] have been published on this subject, their findings have been inconsistent. In 2009, a meta-analysis 16 reported the effects of various interventions, such as counselling, hypnosis and pharmacotherapy, for smoking cessation during pregnancy and indicated that NRT was as effective as cognitive behavioural therapy.…”

Section: Introductionmentioning

confidence: 99%

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Efficacy and safety of pharmacotherapy for smoking cessation among pregnant smokers: a meta‐analysis

Myung

Jung

et al. 2012

BJOG

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Background The efficacy and safety of pharmacotherapy for smoking cessation among pregnant smokers has not yet been established.Objective To investigate the efficacy and safety of pharmacotherapy for smoking cessation among pregnant smokers.Search strategy A search was made of PubMed, Embase and CENTRAL in June 2011.Selection criteria Randomised controlled trials (RCTs), quasiRCTs and retrospective or prospective controlled studies were included.Data collection and analysis The main analyses were designed to examine the efficacy of pharmacotherapy for smoking cessation among pregnant smokers based on the longest follow-up data available and from data obtained at the latest available time-point in pregnancy in each study.Main results Of 74 articles identified from the databases, seven studies (five RCTs, one quasi-RCT and one prospective study) involving a total of 1386 pregnant smokers, 732 in the intervention groups and 654 in the control groups, were included in the final analyses. In a fixed-effects meta-analysis of all seven studies based on the longest follow-up data available, pharmacotherapy had a significant effect on smoking cessation (relative risk [RR] 1.80; 95% confidence interval [CI] 1.32-2.44). Subgroup meta-analysis by type of study design also showed similar findings for RCTs (RR 1.48; 95% CI 1.04-2.09) and other types of studies (RR 3.25;). The abstinence rate at late pregnancy in the intervention ranged from 7 to 22.6% (mean abstinence rate 13.0%; 95% CI 10.9-15.2%). A few minor adverse effects and serious adverse effects were reported in several studies.Author's conclusions This study indicates that there may be clinical evidence to support the use of pharmacotherapy for smoking cessation among pregnant smokers. Further RCTs are needed.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Efficacy and safety of pharmacotherapy for smoking cessation among pregnant smokers: a meta‐analysis

Myung

Jung

et al. 2012

BJOG

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“…In a double-blind, placebo-controlled trial including seventeen women that received NRT and thirteen women that received a placebo at 12 to 24 weeks gestation, results showed no statistical difference between the intervention and control group for quitting (36). Similarly, a large randomized controlled trial including 1051 women (521 NRT and 530 placebo), showed no significant difference in successful quit attempts after one month of the intervention and post-delivery (37).…”

Section: Nicotine Replacement Therapymentioning

confidence: 94%

Smoking cessation during pregnancy and the potential role of exercise: A narrative review

Nagpal

Fagan

Prapavessis

2017

MRAJ

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Abstract:Smoking during pregnancy increases the risk for maternal and fetal adverse events including gestational hypertension, intrauterine growth restriction, low birth weight and sudden infant death syndrome. It is recommended that clinicians should discuss and prescribe smoking cessation programs to pregnant patients. In this review, the effectiveness of potential interventions including cognitive behavioral therapy (CBT) and nicotine replacement therapy (NRT) are examined and compared to the potential of exercise-aided smoking cessation programs. There is limited research available to confidently conclude that CBT on its own is an effective approach to reducing smoking during pregnancy. NRT has shown some success in reducing the total number of cigarettes smoked however the low dose of nicotine made available through NRT still poses as a risk to the developing fetus. Exercise has shown to have an acute effect on decreasing cravings and withdrawal symptoms, however there is limited research conducted for long-term cessation programs. This review provides information regarding the current gaps in literature that need to be addressed in order to confidently determine the effect exercise may have on smoking cessation during pregnancy. Additionally, the role of physicians in promoting and prescribing exercise is discussed.

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“…Three NRT effi cacy studies have been conducted in pregnancy ( Kapur, Hackman, Selby, Klein, & Koren, 2001 ;Oncken et al, 2008 ;Wisborg, Henriksen, Jespersen, & Secher, 2000 ). In Note.…”

Section: Effectiveness and Effi Cacy Studiesmentioning

confidence: 99%

What do we know about the role of pharmacotherapy for smoking cessation before or during pregnancy?

Oncken¹,

Kranzler²

2009

Nicotine &Amp; Tobacco Research

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Randomized, double-blind, placebo-controlled trial of nicotine replacement therapy in pregnancy

Cited by 68 publications

References 6 publications

Efficacy and safety of pharmacotherapy for smoking cessation among pregnant smokers: a meta‐analysis

Efficacy and safety of pharmacotherapy for smoking cessation among pregnant smokers: a meta‐analysis

Smoking cessation during pregnancy and the potential role of exercise: A narrative review

What do we know about the role of pharmacotherapy for smoking cessation before or during pregnancy?

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